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PRJNA207719: Tissue specific transcriptome profiling

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Results for rorc

Z-value: 0.92

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Transcription factors associated with rorc

Gene Symbol Gene ID Gene Info
rorc
ENSDARG00000087195 RAR-related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rorcdr11_v1_chr16_+_17913936_179139450.454.4e-01Click!

Activity profile of rorc motif

Sorted Z-values of rorc motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_5683147 0.84 ENSDART00000102766
ENSDART00000067351
tnnt2a
troponin T type 2a (cardiac)
chr14_+_17376940 0.66 ENSDART00000054590
ENSDART00000010148
spon2b
spondin 2b, extracellular matrix protein
chr19_+_18797623 0.54 ENSDART00000166172
ddah2
dimethylarginine dimethylaminohydrolase 2
chr3_+_59935606 0.45 ENSDART00000154157
arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr15_-_37829160 0.45 ENSDART00000099425
ctrl
chymotrypsin-like
chr16_+_17715243 0.44 ENSDART00000149437
ENSDART00000149596
si:dkey-87o1.2
si:dkey-87o1.2
chr21_+_27189490 0.42 ENSDART00000125349
bada
BCL2 associated agonist of cell death a
chr2_-_56649883 0.40 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr16_-_47426482 0.37 ENSDART00000148631
ENSDART00000149723
sept7b
septin 7b
chr22_-_834106 0.36 ENSDART00000105873
cry4
cryptochrome circadian clock 4
chr20_+_16750177 0.35 ENSDART00000185357
calm1b
calmodulin 1b
chr2_+_48282590 0.34 ENSDART00000035338
lpar5a
lysophosphatidic acid receptor 5a
chr18_+_36631923 0.33 ENSDART00000098980
znf296
zinc finger protein 296
chr4_-_4129187 0.32 ENSDART00000146889
asb15b
ankyrin repeat and SOCS box containing 15b
chr25_-_17918536 0.31 ENSDART00000148660
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr23_-_36316352 0.31 ENSDART00000014840
nfe2
nuclear factor, erythroid 2
chr19_+_30990129 0.30 ENSDART00000052169
ENSDART00000193376
sync
syncoilin, intermediate filament protein
chr15_-_12360409 0.28 ENSDART00000164596
tmprss13a
transmembrane protease, serine 13a
chr8_+_6576940 0.26 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr25_-_17918810 0.25 ENSDART00000023959
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr2_-_56655769 0.24 ENSDART00000113589
gpx4b
glutathione peroxidase 4b
chr5_+_19261687 0.24 ENSDART00000139401
atp8b5a
ATPase phospholipid transporting 8B5a
chr2_+_58841181 0.23 ENSDART00000164102
cirbpa
cold inducible RNA binding protein a
chr25_-_32888115 0.23 ENSDART00000087586
c2cd4a
C2 calcium dependent domain containing 4A
chr3_-_34115886 0.22 ENSDART00000151531
ighv4-1
immunoglobulin heavy variable 4-1
chr21_+_40106448 0.22 ENSDART00000100166
serpinf1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr8_-_2602572 0.22 ENSDART00000110482
zdhhc12a
zinc finger, DHHC-type containing 12a
chr5_+_19261391 0.21 ENSDART00000089173
atp8b5a
ATPase phospholipid transporting 8B5a
chr16_+_30438041 0.21 ENSDART00000137977
pear1
platelet endothelial aggregation receptor 1
chr3_+_14641962 0.21 ENSDART00000091070
zgc:158403
zgc:158403
chr14_-_29859067 0.20 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr5_-_63281395 0.20 ENSDART00000005696
tbcelb
tubulin folding cofactor E-like b
chr11_+_10975012 0.20 ENSDART00000192872
itgb6
integrin, beta 6
chr2_-_8648440 0.20 ENSDART00000135743
si:ch211-71m22.3
si:ch211-71m22.3
chr11_-_24458786 0.20 ENSDART00000089713
mxra8a
matrix-remodelling associated 8a
chr19_+_42336523 0.19 ENSDART00000151304
anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr19_+_30990815 0.19 ENSDART00000134645
sync
syncoilin, intermediate filament protein
chr22_-_38480186 0.19 ENSDART00000171704
soul4
heme-binding protein soul4
chr1_+_17527931 0.19 ENSDART00000131927
casp3a
caspase 3, apoptosis-related cysteine peptidase a
chr22_+_36704764 0.19 ENSDART00000146662
trim35-33
tripartite motif containing 35-33
chr10_-_25628555 0.19 ENSDART00000143978
tiam1a
T cell lymphoma invasion and metastasis 1a
chr11_+_22134540 0.18 ENSDART00000190502
MDFI
si:dkey-91m3.1
chr7_+_19835569 0.18 ENSDART00000149812
ovol1a
ovo-like zinc finger 1a
chr16_-_27442344 0.18 ENSDART00000027545
erp44
endoplasmic reticulum protein 44
chr19_+_4990496 0.18 ENSDART00000151050
ENSDART00000017535
zgc:91968
zgc:91968
chr8_+_26034623 0.18 ENSDART00000004521
ENSDART00000142555
arih2
ariadne homolog 2 (Drosophila)
chr10_+_44692272 0.17 ENSDART00000157458
ubc
ubiquitin C
chr10_+_9561066 0.17 ENSDART00000136281
si:ch211-243g18.2
si:ch211-243g18.2
chr8_+_43340995 0.16 ENSDART00000038566
rflna
refilin A
chr20_-_9980318 0.16 ENSDART00000080664
ACTC1
zgc:86709
chr19_+_4990320 0.16 ENSDART00000147056
zgc:91968
zgc:91968
chr15_-_43625549 0.16 ENSDART00000168589
ctsc
cathepsin C
chr3_+_32698424 0.15 ENSDART00000055340
fus
FUS RNA binding protein
chr1_-_12393060 0.15 ENSDART00000079782
sclt1
sodium channel and clathrin linker 1
chr22_-_600016 0.15 ENSDART00000086434
tmcc2
transmembrane and coiled-coil domain family 2
chr2_+_49417900 0.15 ENSDART00000122742
ENSDART00000160783
rorcb
RAR-related orphan receptor C b
chr2_+_27867830 0.15 ENSDART00000128193
rnf152
ring finger protein 152
chr1_-_49498116 0.14 ENSDART00000137357
zgc:175214
zgc:175214
chr13_+_21768447 0.14 ENSDART00000100941
chchd1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr3_-_29508959 0.14 ENSDART00000055408
cyth4a
cytohesin 4a
chr2_-_25120197 0.13 ENSDART00000132549
pccb
propionyl CoA carboxylase, beta polypeptide
chr9_-_52598343 0.13 ENSDART00000167922
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr11_+_10975481 0.13 ENSDART00000160488
itgb6
integrin, beta 6
chr8_-_25771474 0.13 ENSDART00000193883
suv39h1b
suppressor of variegation 3-9 homolog 1b
chr21_+_30549512 0.13 ENSDART00000132831
rab38c
RAB38c, member of RAS oncogene family
chr18_+_20225961 0.12 ENSDART00000045679
tle3a
transducin-like enhancer of split 3a
chr22_+_8612462 0.12 ENSDART00000114586
CR450686.1

chr11_+_26363435 0.12 ENSDART00000088800
ppcs
phosphopantothenoylcysteine synthetase
chr16_+_11242443 0.12 ENSDART00000024935
gsk3ab
glycogen synthase kinase 3 alpha b
chr10_-_1788376 0.12 ENSDART00000123842
epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr15_+_19682013 0.12 ENSDART00000127368
si:dkey-4p15.5
si:dkey-4p15.5
chr21_+_19517492 0.12 ENSDART00000123168
ENSDART00000187993
gzmk
granzyme K
chr17_-_31044803 0.12 ENSDART00000185941
ENSDART00000152016
eml1
echinoderm microtubule associated protein like 1
chr5_-_69523816 0.12 ENSDART00000112692
si:ch211-157p22.10
si:ch211-157p22.10
chr3_-_26191960 0.12 ENSDART00000113843
ypel3
yippee-like 3
chr15_-_25304710 0.11 ENSDART00000190690
pafah1b1a
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a
chr9_+_13682133 0.10 ENSDART00000175639
mpp4a
membrane protein, palmitoylated 4a (MAGUK p55 subfamily member 4)
chr11_-_39118882 0.10 ENSDART00000113185
ENSDART00000156526
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr5_+_19413838 0.10 ENSDART00000089014
ENSDART00000146215
myo1ha
myosin IHa
chr8_-_29706882 0.10 ENSDART00000045909
prf1.5
perforin 1.5
chr12_+_1286642 0.10 ENSDART00000157467
pemt
phosphatidylethanolamine N-methyltransferase
chr15_-_2841677 0.10 ENSDART00000026145
ENSDART00000180290
AMOTL1
angiomotin like 1
chr1_-_29658721 0.10 ENSDART00000132063
si:dkey-1h24.6
si:dkey-1h24.6
chr17_-_2126517 0.09 ENSDART00000013093
zfyve19
zinc finger, FYVE domain containing 19
chr19_+_43314700 0.09 ENSDART00000049045
ENSDART00000133158
matn1
matrilin 1
chr21_-_25613249 0.09 ENSDART00000137896
fibpb
fibroblast growth factor (acidic) intracellular binding protein b
chr18_-_15911394 0.09 ENSDART00000091339
plekhg7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr1_+_15204633 0.09 ENSDART00000188410
itln1
intelectin 1
chr20_+_34320635 0.08 ENSDART00000153207
ivns1abpa
influenza virus NS1A binding protein a
chr5_+_52167986 0.08 ENSDART00000162256
ENSDART00000073626
slc14a2
solute carrier family 14 (urea transporter), member 2
chr11_-_42396302 0.08 ENSDART00000165624
slmapa
sarcolemma associated protein a
chr13_-_3936555 0.08 ENSDART00000017052
ncoa4
nuclear receptor coactivator 4
chr19_+_24896409 0.08 ENSDART00000049840
eya3
EYA transcriptional coactivator and phosphatase 3
chr4_-_9780931 0.08 ENSDART00000134280
ENSDART00000150664
ENSDART00000150304
ENSDART00000080744
svopl
SVOP-like
chr19_+_10860485 0.08 ENSDART00000169962
si:ch73-347e22.4
si:ch73-347e22.4
chr21_-_5881344 0.08 ENSDART00000009241
rpl35
ribosomal protein L35
chr10_-_44341288 0.07 ENSDART00000166131
zswim6
zinc finger, SWIM-type containing 6
chr7_+_66048102 0.07 ENSDART00000104523
arntl1b
aryl hydrocarbon receptor nuclear translocator-like 1b
chr20_-_14680897 0.07 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr2_+_49864219 0.07 ENSDART00000187744
rpl37
ribosomal protein L37
chr16_-_24561354 0.07 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
si:ch211-79k12.2
chr24_+_24809877 0.07 ENSDART00000185117
dnajc5b
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr20_-_30377221 0.06 ENSDART00000126229
rps7
ribosomal protein S7
chr15_+_17100412 0.06 ENSDART00000154418
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr22_-_11124419 0.06 ENSDART00000149634
atp6ap2
ATPase H+ transporting accessory protein 2
chr3_+_60761811 0.05 ENSDART00000053482
tsen54
TSEN54 tRNA splicing endonuclease subunit
chr23_-_36724575 0.05 ENSDART00000159560
agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_-_1948784 0.05 ENSDART00000082475
nr1d4b
nuclear receptor subfamily 1, group D, member 4b
chr15_+_17100697 0.05 ENSDART00000183565
ENSDART00000123197
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr17_-_24364527 0.05 ENSDART00000155192
wdpcp
WD repeat containing planar cell polarity effector
chr25_+_11389220 0.04 ENSDART00000187787
AGBL1
si:ch73-141f14.1
chr25_+_3035384 0.04 ENSDART00000184219
ENSDART00000149360
mpi
mannose phosphate isomerase
chr8_+_3649036 0.04 ENSDART00000033152
rab35b
RAB35, member RAS oncogene family b
chr22_-_621609 0.04 ENSDART00000137264
ENSDART00000106636
srsf3b
serine/arginine-rich splicing factor 3b
chr18_+_7594012 0.04 ENSDART00000062150
zgc:77752
zgc:77752
chr8_+_18464235 0.04 ENSDART00000110571
alkal1
ALK and LTK ligand 1
chr24_-_982443 0.04 ENSDART00000063151
napga
N-ethylmaleimide-sensitive factor attachment protein, gamma a
chr5_-_30079434 0.04 ENSDART00000133981
bco2a
beta-carotene oxygenase 2a
chr16_+_16265850 0.03 ENSDART00000181265
setd2
SET domain containing 2
chr4_+_38103421 0.03 ENSDART00000164164
znf1016
zinc finger protein 1016
chr25_-_37227491 0.03 ENSDART00000156647
glg1a
golgi glycoprotein 1a
chr7_+_48675347 0.03 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr7_+_65240227 0.03 ENSDART00000168287
bco1l
beta-carotene oxygenase 1, like
chr19_+_41173386 0.03 ENSDART00000142773
asb4
ankyrin repeat and SOCS box containing 4
chr6_-_49159207 0.03 ENSDART00000041942
tspan2a
tetraspanin 2a
chr15_+_19681718 0.03 ENSDART00000164803
si:dkey-4p15.5
si:dkey-4p15.5
chr7_+_24573721 0.03 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
si:dkeyp-75h12.7
chr23_+_44741500 0.03 ENSDART00000166421
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr22_-_6420239 0.03 ENSDART00000148385
zgc:171699
zgc:171699
chr12_+_7399403 0.03 ENSDART00000103526
bicc1b
BicC family RNA binding protein 1b
chr6_+_2030703 0.03 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quo
quattro
chr19_-_8096984 0.02 ENSDART00000146987
si:dkey-266f7.9
si:dkey-266f7.9
chr19_+_2590182 0.02 ENSDART00000162293
si:ch73-345f18.3
si:ch73-345f18.3
chr14_-_34700633 0.02 ENSDART00000150358
ablim3
actin binding LIM protein family, member 3
chr12_+_30789611 0.02 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr4_+_10616626 0.01 ENSDART00000067251
ENSDART00000143690
cped1
cadherin-like and PC-esterase domain containing 1
chr7_+_22313533 0.01 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr22_-_18546241 0.01 ENSDART00000105404
ENSDART00000105405
cirbpb
cold inducible RNA binding protein b
chr5_-_7513082 0.01 ENSDART00000158913
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr2_-_38337122 0.00 ENSDART00000076523
ENSDART00000187473
slc7a8b
solute carrier family 7 (amino acid transporter light chain, L system), member 8b
chr3_-_5362347 0.00 ENSDART00000187511
trim35-7
tripartite motif containing 35-7
chr9_-_43207768 0.00 ENSDART00000192523
sestd1
SEC14 and spectrin domains 1
chr8_+_43016714 0.00 ENSDART00000142671
rassf2a
Ras association (RalGDS/AF-6) domain family member 2a
chr8_+_18463797 0.00 ENSDART00000148958
alkal1
ALK and LTK ligand 1

Network of associatons between targets according to the STRING database.

First level regulatory network of rorc

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.1 0.5 GO:0045429 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.1 0.3 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.1 0.2 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.1 0.2 GO:0061182 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.0 0.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.1 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 1.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.0 0.2 GO:0070285 pigment cell development(GO:0070285)
0.0 0.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.3 GO:0090382 phagosome maturation(GO:0090382)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.0 GO:0042546 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.0 GO:0097541 axonemal basal plate(GO:0097541)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.8 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.2 GO:0031386 protein tag(GO:0031386)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism