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PRJNA207719: Tissue specific transcriptome profiling

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Results for rx1+rx2

Z-value: 0.85

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Transcription factors associated with rx1+rx2

Gene Symbol Gene ID Gene Info
rx2
ENSDARG00000040321 retinal homeobox gene 2
rx1
ENSDARG00000071684 retinal homeobox gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rx1dr11_v1_chr22_-_5006119_5006119-0.177.8e-01Click!
rx2dr11_v1_chr2_-_55853943_55853943-0.079.1e-01Click!

Activity profile of rx1+rx2 motif

Sorted Z-values of rx1+rx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_6751405 0.93 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr21_+_6751760 0.72 ENSDART00000135914
olfm1b
olfactomedin 1b
chr10_-_34002185 0.60 ENSDART00000046599
zar1l
zygote arrest 1-like
chr15_-_5815006 0.53 ENSDART00000102459
rbp2a
retinol binding protein 2a, cellular
chr18_-_5598958 0.53 ENSDART00000161538
cyp1a
cytochrome P450, family 1, subfamily A
chr3_-_26017831 0.53 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr20_+_43925266 0.52 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr16_+_23984179 0.48 ENSDART00000175879
apoc2
apolipoprotein C-II
chr7_+_6652967 0.45 ENSDART00000102681
pnp5a
purine nucleoside phosphorylase 5a
chr18_-_40708537 0.41 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr5_+_37903790 0.38 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr2_+_6255434 0.33 ENSDART00000139429
zp3b
zona pellucida glycoprotein 3b
chr16_-_31622777 0.26 ENSDART00000137311
ENSDART00000002930
phf20l1
PHD finger protein 20 like 1
chr3_+_17537352 0.24 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr5_+_32260502 0.24 ENSDART00000149020
si:ch211-158m24.12
si:ch211-158m24.12
chr16_-_31351419 0.24 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr17_+_24821627 0.23 ENSDART00000112389
wdr43
WD repeat domain 43
chr22_+_7738966 0.21 ENSDART00000147073
si:ch73-44m9.5
si:ch73-44m9.5
chr16_-_13818061 0.21 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr17_+_24318753 0.19 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr12_+_47698356 0.17 ENSDART00000112010
lzts2b
leucine zipper, putative tumor suppressor 2b
chr7_+_54642005 0.17 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr15_-_14552101 0.16 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr25_+_11008419 0.15 ENSDART00000156589
mhc1lia
major histocompatibility complex class I LIA
chr24_-_25144441 0.15 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr23_+_12134839 0.14 ENSDART00000128551
ENSDART00000141204
ttll9
tubulin tyrosine ligase-like family, member 9
chr4_-_9891874 0.14 ENSDART00000067193
adm2a
adrenomedullin 2a
chr3_-_23407720 0.13 ENSDART00000155658
rapgefl1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr22_+_19407531 0.13 ENSDART00000141060
si:dkey-78l4.2
si:dkey-78l4.2
chr7_+_34620418 0.13 ENSDART00000081338
slc9a5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr14_+_901847 0.13 ENSDART00000166991
si:ch73-208h1.2
si:ch73-208h1.2
chr8_-_53044300 0.12 ENSDART00000191653
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr22_+_5123479 0.12 ENSDART00000111822
ENSDART00000081910
loxl5a
lysyl oxidase-like 5a
chr6_+_36839509 0.12 ENSDART00000190605
ENSDART00000104160
zgc:110788
zgc:110788
chr6_-_7720332 0.12 ENSDART00000135945
rpsa
ribosomal protein SA
chr20_-_43663494 0.12 ENSDART00000144564
BX470188.1

chr14_-_14659023 0.12 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr17_-_53329704 0.12 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1
chr24_+_38301080 0.11 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr4_+_9467049 0.11 ENSDART00000012659
zgc:55888
zgc:55888
chr9_-_52962521 0.11 ENSDART00000170419
CU855885.1

chr7_+_46368520 0.10 ENSDART00000192821
znf536
zinc finger protein 536
chr8_-_24502997 0.09 ENSDART00000184801
ENSDART00000179794
BX296549.1

chr16_-_27677930 0.09 ENSDART00000145991
tbrg4
transforming growth factor beta regulator 4
chr22_-_20011476 0.09 ENSDART00000093312
ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr4_-_4387012 0.09 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr15_-_19051152 0.08 ENSDART00000186453
arhgap32a
Rho GTPase activating protein 32a
chr11_+_2855430 0.08 ENSDART00000172837
kif21b
kinesin family member 21B
chr14_-_4170654 0.08 ENSDART00000188347
si:dkey-185e18.7
si:dkey-185e18.7
chr14_+_40874608 0.08 ENSDART00000168448
si:ch211-106m9.1
si:ch211-106m9.1
chr22_+_23359369 0.08 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr9_+_45493341 0.08 ENSDART00000145616
adarb1b
adenosine deaminase, RNA-specific, B1b
chr1_+_35985813 0.08 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
zgc:152968
chr23_+_43255328 0.08 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr2_+_10007113 0.08 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr5_-_25733745 0.07 ENSDART00000051566
zgc:101016
zgc:101016
chr15_+_45640906 0.07 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr16_+_35379720 0.07 ENSDART00000170497
si:dkey-34d22.2
si:dkey-34d22.2
chr9_-_11676491 0.07 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr8_+_28695914 0.07 ENSDART00000033386
ocstamp
osteoclast stimulatory transmembrane protein
chr5_+_58550795 0.07 ENSDART00000192282
pou2f3
POU class 2 homeobox 3
chr20_-_13774826 0.07 ENSDART00000063831
opn8c
opsin 8, group member c
chr7_-_33960170 0.07 ENSDART00000180766
skor1a
SKI family transcriptional corepressor 1a
chr6_+_40922572 0.07 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr21_-_30082414 0.06 ENSDART00000157307
ENSDART00000155188
ccnjl
cyclin J-like
chr21_-_2341937 0.06 ENSDART00000158459
zgc:193790
zgc:193790
chr12_-_41684729 0.06 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr4_-_61691066 0.06 ENSDART00000159114
znf1129
zinc finger protein 1129
chr19_-_5669122 0.06 ENSDART00000112211
si:ch211-264f5.2
si:ch211-264f5.2
chr4_+_306036 0.06 ENSDART00000103659
msgn1
mesogenin 1
chr20_+_29209926 0.06 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr19_+_5480327 0.06 ENSDART00000148794
jupb
junction plakoglobin b
chr5_-_12219572 0.06 ENSDART00000167834
nos1
nitric oxide synthase 1 (neuronal)
chr1_+_44127292 0.05 ENSDART00000160542
cabp2a
calcium binding protein 2a
chr7_+_34453185 0.05 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr15_-_22074315 0.05 ENSDART00000149830
drd2a
dopamine receptor D2a
chr8_-_12264486 0.05 ENSDART00000091612
ENSDART00000135812
dab2ipa
DAB2 interacting protein a
chr1_-_17715493 0.05 ENSDART00000133027
si:dkey-256e7.8
si:dkey-256e7.8
chr8_-_24332284 0.05 ENSDART00000163241
pimr142
Pim proto-oncogene, serine/threonine kinase, related 142
chr7_+_26173751 0.05 ENSDART00000065131
si:ch211-196f2.7
si:ch211-196f2.7
chr9_+_1313418 0.05 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr16_-_32837806 0.05 ENSDART00000003997
MCHR2
si:dkey-165n16.5
chr8_-_24366726 0.05 ENSDART00000182351
ENSDART00000187099
ENSDART00000181534
CR450805.1

chr6_+_7421898 0.05 ENSDART00000043946
ccdc65
coiled-coil domain containing 65
chr2_+_53204750 0.04 ENSDART00000163644
zgc:165603
zgc:165603
chr15_+_5360407 0.04 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr22_-_20924564 0.04 ENSDART00000100642
ENSDART00000032770
ell
elongation factor RNA polymerase II
chr11_-_21528056 0.04 ENSDART00000181626
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr8_+_16025554 0.04 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr14_-_33824329 0.04 ENSDART00000189271
ENSDART00000180458
vimr2
vimentin-related 2
chr11_+_7264457 0.04 ENSDART00000154182
reep6
receptor accessory protein 6
chr2_+_50608099 0.04 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr16_+_54263921 0.04 ENSDART00000002856
drd2l
dopamine receptor D2 like
chr8_+_25034544 0.04 ENSDART00000123300
ngrn
neugrin, neurite outgrowth associated
chr7_-_41746427 0.04 ENSDART00000174232
arl8
ADP-ribosylation factor-like 8
chr18_+_28106139 0.03 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr8_-_16697615 0.03 ENSDART00000187929
rpe65b
retinal pigment epithelium-specific protein 65b
chr23_+_16638639 0.03 ENSDART00000143545
snphb
syntaphilin b
chr4_+_11723852 0.03 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr21_-_33995710 0.03 ENSDART00000100508
ENSDART00000179622
ebf1b
early B cell factor 1b
chr15_-_18200358 0.03 ENSDART00000158569
si:ch211-247l8.8
si:ch211-247l8.8
chr4_-_56954002 0.03 ENSDART00000160934
si:dkey-269o24.1
si:dkey-269o24.1
chr8_-_39822917 0.03 ENSDART00000067843
zgc:162025
zgc:162025
chr13_-_37229245 0.03 ENSDART00000140923
si:dkeyp-77c8.5
si:dkeyp-77c8.5
chr20_+_28803977 0.02 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr21_-_45188233 0.02 ENSDART00000130880
si:ch73-269m14.2
si:ch73-269m14.2
chr20_+_29209615 0.02 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr17_+_3379673 0.02 ENSDART00000176354
sntg2
syntrophin, gamma 2
chr8_-_25034411 0.02 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr15_-_33925851 0.02 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr20_+_29209767 0.01 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr11_+_16152316 0.01 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr6_-_40922971 0.01 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr18_+_21408794 0.01 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr24_-_36680261 0.01 ENSDART00000059507
ccr10
chemokine (C-C motif) receptor 10
chr10_+_35358675 0.01 ENSDART00000193263
si:dkey-259j3.5
si:dkey-259j3.5
chr25_+_30131055 0.01 ENSDART00000152705
api5
apoptosis inhibitor 5
chr7_+_24023653 0.00 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr24_-_18809433 0.00 ENSDART00000152009
arfgef1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr24_+_19415124 0.00 ENSDART00000186931
sulf1
sulfatase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of rx1+rx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0007585 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.1 0.2 GO:0042755 eating behavior(GO:0042755)
0.0 0.5 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.0 0.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.0 0.1 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0003406 retinal pigment epithelium development(GO:0003406)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 0.1 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070330 aromatase activity(GO:0070330)
0.1 0.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.5 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation