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PRJNA207719: Tissue specific transcriptome profiling

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Results for rxrbb

Z-value: 0.83

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Transcription factors associated with rxrbb

Gene Symbol Gene ID Gene Info
ENSDARG00000002006 retinoid x receptor, beta b
ENSDARG00000117079 retinoid x receptor, beta b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rxrbbdr11_v1_chr16_+_18534834_185348340.951.5e-02Click!

Activity profile of rxrbb motif

Sorted Z-values of rxrbb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_45128375 2.21 ENSDART00000164805
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr13_-_9318891 1.27 ENSDART00000137364
si:dkey-33c12.3
chr7_-_38633867 1.19 ENSDART00000137424
C1q and TNF related 4
chr23_-_45504991 1.04 ENSDART00000148761
collagen type XXIV alpha 1
chr25_+_21829777 0.84 ENSDART00000027393
creatine kinase, mitochondrial 1
chr8_+_36803415 0.83 ENSDART00000111680
IQ motif and Sec7 domain 2b
chr24_-_21172122 0.81 ENSDART00000154259
ATPase H+ transporting V1 subunit Ab
chr10_-_17745345 0.75 ENSDART00000132690
ENSDART00000135376
si:dkey-200l5.4
chr19_+_2275019 0.73 ENSDART00000136138
integrin, beta 8
chr22_-_3595439 0.70 ENSDART00000083308
protein tyrosine phosphatase, receptor type, s, a
chr25_-_19420949 0.66 ENSDART00000181338
microtubule-associated protein 1Ab
chr13_+_28819768 0.66 ENSDART00000191401
ENSDART00000188895
ENSDART00000101653

chr18_+_27515640 0.61 ENSDART00000181593
tumor protein p53 inducible protein 11b
chr5_+_38276582 0.60 ENSDART00000158532
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr1_+_25848231 0.59 ENSDART00000027973
fatty acid binding protein 2, intestinal
chr21_+_1119046 0.57 ENSDART00000184678

chr24_+_39137001 0.57 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
TBC1 domain family, member 24
chr5_-_23362602 0.56 ENSDART00000137120
glutamate receptor, ionotropic, AMPA 3a
chr19_-_9867001 0.50 ENSDART00000091695
calcium channel, voltage-dependent, gamma subunit 7a
chr25_+_20119466 0.50 ENSDART00000104304
2,3-bisphosphoglycerate mutase
chr16_+_14033121 0.49 ENSDART00000135844
RUN and SH3 domain containing 1
chr3_+_30257582 0.49 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
myosin binding protein C, fast type a
chr18_+_31410652 0.49 ENSDART00000098504
differentially expressed in FDCP 8 homolog (mouse)
chr13_+_28821841 0.48 ENSDART00000179900

chr4_-_858434 0.43 ENSDART00000006961
sine oculis binding protein homolog (Drosophila) b
chr24_-_1021318 0.40 ENSDART00000181403
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr15_+_47386939 0.39 ENSDART00000128224

chr23_+_30730121 0.38 ENSDART00000134141
additional sex combs like transcriptional regulator 1
chr17_+_45737992 0.38 ENSDART00000135073
ENSDART00000143525
ENSDART00000158165
ENSDART00000184167
ENSDART00000109525
asparaginase homolog (S. cerevisiae)
chr12_-_31012741 0.37 ENSDART00000145967
transcription factor 7 like 2
chr9_+_34380299 0.36 ENSDART00000131705
lysosomal-associated membrane protein 1
chr9_-_25255490 0.35 ENSDART00000141502
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
chr15_+_15856178 0.35 ENSDART00000080338
dual specificity phosphatase 14
chr9_-_37613792 0.35 ENSDART00000138345
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr19_+_3056450 0.33 ENSDART00000141324
ENSDART00000082353
heat shock transcription factor 1
chr14_-_13048355 0.33 ENSDART00000166434
si:dkey-35h6.1
chr10_+_20128267 0.33 ENSDART00000064615
dematin actin binding protein
chr24_+_39034090 0.32 ENSDART00000185763
calpain 15
chr2_-_32555625 0.30 ENSDART00000056641
ENSDART00000137531
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr23_-_42810664 0.30 ENSDART00000102328
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a
chr19_+_177455 0.28 ENSDART00000111580
transmembrane protein 65
chr24_-_1341543 0.28 ENSDART00000169341
neuropilin 1a
chr13_-_41546779 0.27 ENSDART00000163331
protocadherin-related 15a
chr11_+_19433936 0.27 ENSDART00000162081
prickle homolog 2b
chr12_+_26670778 0.27 ENSDART00000144355
Rho GTPase activating protein 12b
chr17_-_20711735 0.26 ENSDART00000150056
ankyrin 3b
chr17_+_11675362 0.26 ENSDART00000157911
kinesin family member 26Ba
chr3_+_59117136 0.24 ENSDART00000182745
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr12_-_33568174 0.23 ENSDART00000142329
tudor and KH domain containing
chr4_-_37587110 0.23 ENSDART00000169302
zinc finger protein 1100
chr17_+_21817382 0.22 ENSDART00000079011
ENSDART00000189387
IKAROS family zinc finger 5
chr18_-_158541 0.22 ENSDART00000188914
ENSDART00000191052
transient receptor potential cation channel, subfamily M, member 7
chr20_-_53078607 0.22 ENSDART00000163494
ENSDART00000191730

chr2_-_22659450 0.22 ENSDART00000115025
THAP domain containing 4
chr2_-_7696503 0.22 ENSDART00000169709

chr16_-_29146624 0.21 ENSDART00000159814
ENSDART00000009826
myocyte enhancer factor 2d
chr5_-_27994679 0.21 ENSDART00000132740
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr25_-_31118923 0.21 ENSDART00000009126
ENSDART00000188286
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr9_+_32978302 0.21 ENSDART00000007630
nescient helix loop helix 2
chr21_-_35832548 0.20 ENSDART00000180840
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr19_+_19032141 0.20 ENSDART00000192432
copine IVb
chr8_-_979735 0.19 ENSDART00000149612
zinc finger protein 366
chr24_-_7587401 0.19 ENSDART00000093163
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr6_-_11523987 0.18 ENSDART00000189363
GULP, engulfment adaptor PTB domain containing 1b
chr12_+_46708920 0.18 ENSDART00000153089
exocyst complex component 7
chr9_+_22782027 0.18 ENSDART00000090816
replication timing regulatory factor 1
chr12_+_3848109 0.18 ENSDART00000144067
ENSDART00000192042
calcium binding protein 5a
chr23_+_2914577 0.18 ENSDART00000184897
zgc:158828
chr25_+_31238606 0.17 ENSDART00000149439
troponin I type 2a (skeletal, fast), tandem duplicate 2
chr20_-_18382708 0.17 ENSDART00000170864
ENSDART00000166762
ENSDART00000191333
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr12_+_17439580 0.16 ENSDART00000189257
ATPase family, AAA domain containing 1b
chr2_+_42191592 0.16 ENSDART00000144716
caveolae associated protein 4a
chr4_-_38421217 0.16 ENSDART00000164517
szinc finger protein 1092
chr12_-_48671612 0.16 ENSDART00000007202
zgc:92749
chr1_+_58353661 0.15 ENSDART00000140074
si:dkey-222h21.2
chr13_-_4018888 0.15 ENSDART00000058238
tight junction associated protein 1 (peripheral)
chr4_+_45274792 0.15 ENSDART00000150295
zinc finger protein 1138
chr8_+_8012570 0.15 ENSDART00000183429
si:ch211-169p10.1
chr23_-_27050083 0.14 ENSDART00000142324
ENSDART00000133249
ENSDART00000138751
ENSDART00000128718
zgc:66440
chr22_+_10752787 0.13 ENSDART00000186542
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr22_-_20950448 0.13 ENSDART00000002029
FK506 binding protein 8
chr23_-_18595020 0.13 ENSDART00000187032
ENSDART00000191047
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr10_-_19006579 0.13 ENSDART00000141764
adrenoceptor alpha 1Ab
chr17_-_7371564 0.13 ENSDART00000060336
RAB32b, member RAS oncogene family
chr2_-_22660232 0.12 ENSDART00000174742
THAP domain containing 4
chr21_-_21515466 0.12 ENSDART00000147593
nectin cell adhesion molecule 3b
chr13_+_45980163 0.12 ENSDART00000074547
ENSDART00000005195
BSD domain containing 1
chr16_+_28601974 0.12 ENSDART00000018235
carnitine O-octanoyltransferase
chr21_-_11820379 0.12 ENSDART00000126640
si:dkey-6b12.5
chr3_+_39566999 0.11 ENSDART00000146867
aldolase a, fructose-bisphosphate, a
chr16_+_25809235 0.11 ENSDART00000181196
immunity-related GTPase family, q1
chr1_+_23783349 0.11 ENSDART00000007531
slit homolog 2 (Drosophila)
chr6_+_40952031 0.10 ENSDART00000189219
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_56649883 0.09 ENSDART00000191786
glutathione peroxidase 4b
chr18_+_30441740 0.09 ENSDART00000189074
Gse1 coiled-coil protein
chr6_+_40775800 0.09 ENSDART00000085090
si:ch211-157b11.8
chr6_-_14004772 0.09 ENSDART00000185629
zgc:92027
chr22_+_10752511 0.08 ENSDART00000081188
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr7_+_25000060 0.08 ENSDART00000039265
ENSDART00000141814
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr13_-_37127970 0.08 ENSDART00000135510
spectrin repeat containing, nuclear envelope 2b
chr18_-_16801033 0.08 ENSDART00000100100
adrenomedullin b
chr19_+_5146460 0.08 ENSDART00000150740
si:dkey-89b17.4
chr9_+_54644626 0.08 ENSDART00000190609
EGF-like-domain, multiple 6
chr5_-_56416188 0.07 ENSDART00000146773
acetyl-CoA carboxylase alpha
chr20_+_27519429 0.07 ENSDART00000136251
kinesin family member 26Aa
chr5_-_20491198 0.07 ENSDART00000183051
ENSDART00000144232
FIC domain containing
chr21_-_40015530 0.07 ENSDART00000084237
solute carrier family 47 (multidrug and toxin extrusion), member 2.1
chr16_-_54978981 0.07 ENSDART00000154023
WD and tetratricopeptide repeats 1
chr17_-_25395395 0.07 ENSDART00000170233
family with sequence similarity 167, member B
chr6_+_39930825 0.07 ENSDART00000182352
ENSDART00000186643
ENSDART00000190513
ENSDART00000065092
ENSDART00000188645
inositol 1,4,5-trisphosphate receptor, type 1a
chr16_+_28602423 0.06 ENSDART00000182350
carnitine O-octanoyltransferase
chr11_+_77526 0.06 ENSDART00000193521

chr6_+_13206516 0.06 ENSDART00000036927
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr16_-_47483142 0.06 ENSDART00000147072
collagen triple helix repeat containing 1b
chr18_+_27926839 0.05 ENSDART00000191835
homeodomain interacting protein kinase 3b
chr7_+_7495034 0.05 ENSDART00000102629
ENSDART00000180475
nitrilase 1
chr2_-_8102169 0.05 ENSDART00000131955
plastin 1 (I isoform)
chr19_+_20713424 0.05 ENSDART00000129730
RAB5A, member RAS oncogene family, a
chr12_+_19958845 0.04 ENSDART00000193248
excision repair cross-complementation group 4
chr17_+_21817859 0.04 ENSDART00000143832
ENSDART00000141462
IKAROS family zinc finger 5
chr13_+_21826369 0.04 ENSDART00000165150
ENSDART00000192115
zinc finger, SWIM-type containing 8
chr16_-_6391275 0.04 ENSDART00000060550
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr21_-_26495700 0.03 ENSDART00000109379
CD248 molecule, endosialin b
chr4_+_2655358 0.03 ENSDART00000007638
B cell receptor associated protein 29
chr11_-_11910225 0.03 ENSDART00000159922
si:ch211-69b7.6
chr20_-_51656512 0.03 ENSDART00000129965

chr8_-_44868020 0.03 ENSDART00000142712
calcium channel, voltage-dependent, L type, alpha 1F subunit a
chr3_+_27770110 0.03 ENSDART00000017962
enoyl-CoA delta isomerase 1
chr11_-_3571605 0.03 ENSDART00000167863
si:dkey-33m11.7
chr16_-_24612871 0.03 ENSDART00000155614
ENSDART00000154787
ENSDART00000155983
ENSDART00000156519
FXYD domain containing ion transport regulator 6 like
chr13_-_36418921 0.02 ENSDART00000135804
ddb1 and cul4 associated factor 5
chr13_-_3351708 0.02 ENSDART00000042875
si:ch73-193i2.2
chr4_+_37503994 0.02 ENSDART00000158217
zinc finger protein 1102
chr1_+_58303892 0.02 ENSDART00000147678

chr15_+_45640906 0.01 ENSDART00000149361
ENSDART00000149079
S-antigen; retina and pineal gland (arrestin) b
chr10_-_25204034 0.01 ENSDART00000161100
si:ch211-214k5.6
chr24_-_29586082 0.01 ENSDART00000136763
vav 3 guanine nucleotide exchange factor a
chr9_-_44583167 0.00 ENSDART00000140689
ENSDART00000191842
phosphodiesterase 1A, calmodulin-dependent
chr1_+_58182400 0.00 ENSDART00000144784
si:ch211-15j1.1
chr4_-_16451375 0.00 ENSDART00000192700
ENSDART00000128835
wu:fc23c09

Network of associatons between targets according to the STRING database.

First level regulatory network of rxrbb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.3 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 0.4 GO:0010226 response to lithium ion(GO:0010226)
0.1 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.8 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 2.2 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 0.3 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.0 0.7 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.4 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.1 GO:0007414 axonal defasciculation(GO:0007414)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.5 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.7 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.7 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.0 0.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.0 0.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.2 GO:0048798 somatic muscle development(GO:0007525) swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.0 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.0 GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair(GO:1901255)
0.0 0.3 GO:0009408 response to heat(GO:0009408)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.8 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.4 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 0.4 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.4 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0008305 integrin complex(GO:0008305)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.0 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.8 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.4 GO:0004067 asparaginase activity(GO:0004067)
0.0 2.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.6 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0016415 octanoyltransferase activity(GO:0016415)
0.0 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.4 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac