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PRJNA207719: Tissue specific transcriptome profiling

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Results for six4a+six4b

Z-value: 0.63

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Transcription factors associated with six4a+six4b

Gene Symbol Gene ID Gene Info
six4a
ENSDARG00000004695 SIX homeobox 4a
six4b
ENSDARG00000031983 SIX homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six4bdr11_v1_chr20_+_20484827_20484827-0.563.2e-01Click!
six4adr11_v1_chr13_-_31647323_31647323-0.069.2e-01Click!

Activity profile of six4a+six4b motif

Sorted Z-values of six4a+six4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_37837245 0.58 ENSDART00000171617
epd
ependymin
chr2_+_10134345 0.49 ENSDART00000100725
ahsg2
alpha-2-HS-glycoprotein 2
chr22_+_25242322 0.44 ENSDART00000134628
si:ch211-226h8.8
si:ch211-226h8.8
chr22_+_25236888 0.40 ENSDART00000037286
zgc:172218
zgc:172218
chr22_+_25236657 0.40 ENSDART00000138012
zgc:172218
zgc:172218
chr21_-_26114886 0.34 ENSDART00000139320
nipal4
NIPA-like domain containing 4
chr22_+_21317597 0.34 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr1_-_58562129 0.27 ENSDART00000159070
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr4_-_22519516 0.27 ENSDART00000130409
ENSDART00000186258
ENSDART00000002851
ENSDART00000123801
kdm7aa
lysine (K)-specific demethylase 7Aa
chr9_+_8396755 0.27 ENSDART00000043067
zgc:171776
zgc:171776
chr7_-_41964877 0.26 ENSDART00000092351
ENSDART00000193395
ENSDART00000187947
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr2_+_50626476 0.24 ENSDART00000018150
neurod6b
neuronal differentiation 6b
chr4_-_77506362 0.24 ENSDART00000174387
ENSDART00000181181
CABZ01087415.1

chr13_-_39399967 0.24 ENSDART00000190791
ENSDART00000136267
slc35f3b
solute carrier family 35, member F3b
chr1_-_45889820 0.23 ENSDART00000144735
pnpla6
patatin-like phospholipase domain containing 6
chr2_+_29491314 0.23 ENSDART00000181774
dlgap1a
discs, large (Drosophila) homolog-associated protein 1a
chr4_-_14315855 0.23 ENSDART00000133325
nell2b
neural EGFL like 2b
chr12_+_31616412 0.22 ENSDART00000124439
cpn1
carboxypeptidase N, polypeptide 1
chr8_+_49149907 0.22 ENSDART00000138746
snpha
syntaphilin a
chr2_-_30770736 0.21 ENSDART00000131230
rgs20
regulator of G protein signaling 20
chr11_+_40649412 0.21 ENSDART00000043016
ENSDART00000134560
slc45a1
solute carrier family 45, member 1
chr23_-_7125494 0.19 ENSDART00000111929
slco4a1
solute carrier organic anion transporter family, member 4A1
chr18_+_7264961 0.19 ENSDART00000188461
CABZ01015105.1

chr7_+_58699900 0.19 ENSDART00000144009
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr1_-_58561963 0.19 ENSDART00000165040
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr17_-_13072334 0.18 ENSDART00000159598
CU469462.1

chr3_+_12718100 0.18 ENSDART00000162343
ENSDART00000192425
cyp2k20
cytochrome P450, family 2, subfamily k, polypeptide 20
chr21_+_34167178 0.17 ENSDART00000158308
trpc5b
transient receptor potential cation channel, subfamily C, member 5b
chr14_-_2209742 0.17 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr1_+_37752171 0.17 ENSDART00000183247
ENSDART00000189756
ENSDART00000139448
GALNTL6
si:ch211-15e22.3
chr18_+_27511976 0.17 ENSDART00000132017
ENSDART00000140781
tp53i11b
tumor protein p53 inducible protein 11b
chr2_+_38804223 0.17 ENSDART00000147939
carmil3
capping protein regulator and myosin 1 linker 3
chr7_-_54217547 0.16 ENSDART00000162777
ENSDART00000188268
ENSDART00000165875
csnk1g1
casein kinase 1, gamma 1
chr3_-_56896702 0.16 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr13_-_14269626 0.15 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr23_-_33944597 0.15 ENSDART00000133223
si:dkey-190g6.2
si:dkey-190g6.2
chr16_+_50755133 0.14 ENSDART00000029283
IGLON5
zgc:110372
chr18_-_39188664 0.14 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr5_+_13472234 0.14 ENSDART00000114069
ENSDART00000132406
cnnm4b
cyclin and CBS domain divalent metal cation transport mediator 4b
chr21_+_39365920 0.14 ENSDART00000140940
cluhb
clustered mitochondria (cluA/CLU1) homolog b
chr14_-_2318590 0.13 ENSDART00000192735
pcdh2ab8
protocadherin 2 alpha b 8
chr2_-_14793343 0.13 ENSDART00000132264
si:ch73-366i20.1
si:ch73-366i20.1
chr2_-_4797512 0.13 ENSDART00000160765
tnk2b
tyrosine kinase, non-receptor, 2b
chr20_+_34717403 0.13 ENSDART00000034252
pnocb
prepronociceptin b
chr13_+_3954715 0.13 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
lrrc73
leucine rich repeat containing 73
chr7_+_58699718 0.13 ENSDART00000049264
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr20_+_33534038 0.13 ENSDART00000029206
kcnf1a
potassium voltage-gated channel, subfamily F, member 1a
chr7_+_13988075 0.12 ENSDART00000186812
furina
furin (paired basic amino acid cleaving enzyme) a
chr17_-_42213285 0.12 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr2_-_32558795 0.12 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr3_-_40955780 0.12 ENSDART00000130130
cyp3c3
cytochrome P450, family 3, subfamily c, polypeptide 3
chr17_-_1407593 0.12 ENSDART00000157622
ENSDART00000159458
zbtb42
zinc finger and BTB domain containing 42
chr16_-_13818061 0.12 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr5_-_43071058 0.11 ENSDART00000165546
si:dkey-245n4.2
si:dkey-245n4.2
chr10_-_36682509 0.11 ENSDART00000148093
ENSDART00000063365
dnajb13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr6_+_40591149 0.11 ENSDART00000189060
ENSDART00000188298
frs3
fibroblast growth factor receptor substrate 3
chr17_+_7595356 0.10 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr17_+_5768608 0.10 ENSDART00000157039
rp1l1a
retinitis pigmentosa 1-like 1a
chr1_-_7894255 0.10 ENSDART00000167126
ENSDART00000145460
radil
Ras association and DIL domains
chr23_+_27779452 0.10 ENSDART00000134785
kmt2d
lysine (K)-specific methyltransferase 2D
chr7_+_48297842 0.10 ENSDART00000052123
slc25a44b
solute carrier family 25, member 44 b
chr9_-_34882516 0.10 ENSDART00000011163
asmtl
acetylserotonin O-methyltransferase-like
chr24_-_23839647 0.10 ENSDART00000125190
rrs1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr11_+_41560792 0.10 ENSDART00000127292
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr2_-_11662851 0.08 ENSDART00000145108
zgc:110130
zgc:110130
chr7_-_32599669 0.08 ENSDART00000173752
kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr6_-_35310224 0.08 ENSDART00000148997
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr23_+_16469530 0.08 ENSDART00000132898
ntsr1
neurotensin receptor 1 (high affinity)
chr20_+_51813432 0.08 ENSDART00000127444
taf1a
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A
chr2_+_33335911 0.07 ENSDART00000126135
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr23_+_45785563 0.07 ENSDART00000186027
CABZ01088036.1

chr14_+_24042760 0.07 ENSDART00000106096
drd1a
dopamine receptor D1a
chr17_+_15882533 0.06 ENSDART00000164124
gabrr2a
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr18_-_12416019 0.06 ENSDART00000144799
si:ch211-1e14.1
si:ch211-1e14.1
chr7_+_6480212 0.06 ENSDART00000173320
si:cabz01036022.1
si:cabz01036022.1
chr3_+_311833 0.06 ENSDART00000187375
FP326649.2

chr24_-_25166416 0.06 ENSDART00000111552
ENSDART00000169495
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr2_-_40135942 0.05 ENSDART00000176951
ENSDART00000098632
ENSDART00000148563
ENSDART00000149895
epha4a
eph receptor A4a
chr22_+_19262161 0.05 ENSDART00000163654
si:dkey-21e2.12
si:dkey-21e2.12
chr25_-_1235457 0.05 ENSDART00000093093
coro2bb
coronin, actin binding protein, 2Bb
chr1_+_1941031 0.05 ENSDART00000110331
PTGFRN
si:ch211-132g1.7
chr19_+_37135700 0.05 ENSDART00000103159
smim12
small integral membrane protein 12
chr25_-_17528994 0.05 ENSDART00000061712
si:dkey-44k1.5
si:dkey-44k1.5
chr6_-_24301324 0.05 ENSDART00000171401
BX927081.1

chr19_-_6083761 0.05 ENSDART00000151185
ENSDART00000143941
gsk3aa
glycogen synthase kinase 3 alpha a
chr7_+_53498152 0.05 ENSDART00000184497
znf609b
zinc finger protein 609b
chr25_+_19695652 0.05 ENSDART00000104340
mxg
myxovirus (influenza virus) resistance G
chr15_-_35126332 0.04 ENSDART00000007636
zgc:55413
zgc:55413
chr11_+_583725 0.04 ENSDART00000189415
mkrn2os.2
MKRN2 opposite strand, tandem duplicate 2
chr2_+_56213694 0.04 ENSDART00000162582
upf1
upf1 regulator of nonsense transcripts homolog (yeast)
chr12_+_1592146 0.04 ENSDART00000184575
ENSDART00000192902
SLC39A11
solute carrier family 39 member 11
chr6_-_21678263 0.04 ENSDART00000038777
si:dkey-43k4.5
si:dkey-43k4.5
chr11_+_24851671 0.04 ENSDART00000167659
ipo9
importin 9
chr12_-_18872927 0.04 ENSDART00000187717
shisa8b
shisa family member 8b
chr2_-_30784198 0.04 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr12_+_31422557 0.04 ENSDART00000153179
zdhhc6
zinc finger, DHHC-type containing 6
chr8_-_7474997 0.03 ENSDART00000146555
gata1b
GATA binding protein 1b
chr4_-_72468168 0.03 ENSDART00000182995
ENSDART00000174067
CR788316.1

chr22_+_15310103 0.03 ENSDART00000145849
CU104797.1

chr10_-_32610776 0.03 ENSDART00000017436
mogat2
monoacylglycerol O-acyltransferase 2
chr20_-_5052786 0.03 ENSDART00000138818
ENSDART00000181655
ENSDART00000164274
arid1b
AT rich interactive domain 1B (SWI1-like)
chr20_-_6184167 0.03 ENSDART00000147451
b4galt6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr1_-_46632948 0.03 ENSDART00000148893
ENSDART00000053232
cdadc1
cytidine and dCMP deaminase domain containing 1
chr17_-_42213822 0.02 ENSDART00000187904
ENSDART00000180029
nkx2.2a
NK2 homeobox 2a
chr22_-_209741 0.02 ENSDART00000171954
ora1
olfactory receptor class A related 1
chr8_-_3346692 0.02 ENSDART00000057874
FUT9 (1 of many)
zgc:103510
chr2_-_20666920 0.02 ENSDART00000143437
ENSDART00000114546
ENSDART00000136113
ENSDART00000179247
dusp12
dual specificity phosphatase 12
chr5_-_5831037 0.02 ENSDART00000112856
zmp:0000000846
zmp:0000000846
chr25_-_15214161 0.02 ENSDART00000031499
wt1a
wilms tumor 1a
chr5_+_66044128 0.02 ENSDART00000165573
jak2b
Janus kinase 2b
chr9_+_11034314 0.02 ENSDART00000032695
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr8_+_14058646 0.02 ENSDART00000080852
ugt5e1
UDP glucuronosyltransferase 5 family, polypeptide E1
chr16_+_11834516 0.02 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr14_-_4043818 0.01 ENSDART00000179870
snx25
sorting nexin 25
chr2_+_30465102 0.01 ENSDART00000188404
neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr12_-_3962372 0.01 ENSDART00000016791
eif3c
eukaryotic translation initiation factor 3, subunit C
chr7_+_39360797 0.01 ENSDART00000173481
acp2
acid phosphatase 2, lysosomal
chr12_-_4475890 0.01 ENSDART00000092492
si:ch211-173d10.1
si:ch211-173d10.1
chr22_+_2751887 0.01 ENSDART00000133652
si:dkey-20i20.11
si:dkey-20i20.11
chr3_-_34072446 0.01 ENSDART00000151528
ighv8-2
immunoglobulin heavy variable 8-2
chr19_+_16064439 0.00 ENSDART00000151169
gmeb1
glucocorticoid modulatory element binding protein 1
chr21_+_39432248 0.00 ENSDART00000179938
pafah1b1b
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
chr22_+_26853254 0.00 ENSDART00000182487
tmem186
transmembrane protein 186
chr19_+_770300 0.00 ENSDART00000062518
gstr
glutathione S-transferase rho
chr12_-_31484677 0.00 ENSDART00000066578
tectb
tectorin beta
chr15_-_37834433 0.00 ENSDART00000189748
si:dkey-238d18.3
si:dkey-238d18.3
chr3_-_54607166 0.00 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of six4a+six4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071071 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.2 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation