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PRJNA207719: Tissue specific transcriptome profiling

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Results for smad2_smad10a+smad4a_smad1

Z-value: 1.50

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Transcription factors associated with smad2_smad10a+smad4a_smad1

Gene Symbol Gene ID Gene Info
smad2
ENSDARG00000006389 SMAD family member 2
smad10a
ENSDARG00000045094 si_dkey-222b8.1
smad10a
ENSDARG00000070428 si_dkey-222b8.1
smad4a
ENSDARG00000075226 SMAD family member 4a
smad1
ENSDARG00000027199 SMAD family member 1
smad1
ENSDARG00000112617 SMAD family member 1
smad1
ENSDARG00000115674 SMAD family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:dkey-239n17.4dr11_v1_chr16_-_28878080_288780800.884.7e-02Click!
smad1dr11_v1_chr1_-_35929143_359291430.642.5e-01Click!
smad4adr11_v1_chr10_+_585719_5857190.414.9e-01Click!
smad2dr11_v1_chr10_-_14943281_149432810.168.0e-01Click!
si:dkey-222b8.1dr11_v1_chr19_+_23932259_23932259-0.029.8e-01Click!

Activity profile of smad2_smad10a+smad4a_smad1 motif

Sorted Z-values of smad2_smad10a+smad4a_smad1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_4932619 1.20 ENSDART00000103293
ndufa5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr24_-_28243186 1.19 ENSDART00000105691
cox4i1l
cytochrome c oxidase subunit IV isoform 1, like
chr20_-_7648325 1.04 ENSDART00000186541
CR848049.1

chr23_-_39849155 0.90 ENSDART00000115330
ppp1r14c
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr4_-_16412084 0.77 ENSDART00000188460
dcn
decorin
chr19_-_41069573 0.68 ENSDART00000111982
ENSDART00000193142
sgce
sarcoglycan, epsilon
chr21_-_43616586 0.66 ENSDART00000036537
htr2cl2
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2
chr13_+_31648271 0.64 ENSDART00000006648
mnat1
MNAT CDK-activating kinase assembly factor 1
chr23_+_36460239 0.64 ENSDART00000172441
lima1a
LIM domain and actin binding 1a
chr13_+_25433774 0.63 ENSDART00000141255
si:dkey-51a16.9
si:dkey-51a16.9
chr5_+_64900223 0.61 ENSDART00000191677
ptgs1
prostaglandin-endoperoxide synthase 1
chr19_-_5380770 0.55 ENSDART00000000221
krt91
keratin 91
chr10_-_10018794 0.55 ENSDART00000130734
strbp
spermatid perinuclear RNA binding protein
chr19_+_42219165 0.50 ENSDART00000163192
CU896644.1

chr4_-_21466825 0.50 ENSDART00000066897
pawr
PRKC, apoptosis, WT1, regulator
chr11_-_13152524 0.48 ENSDART00000181440
ENSDART00000191997
elovl1b
ELOVL fatty acid elongase 1b
chr10_+_20364009 0.48 ENSDART00000186139
ENSDART00000080395
golga7
golgin A7
chr11_-_497854 0.46 ENSDART00000104520
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr11_+_45255774 0.45 ENSDART00000172838
aspscr1
alveolar soft part sarcoma chromosome region, candidate 1
chr15_+_28303161 0.44 ENSDART00000087926
myo1cb
myosin Ic, paralog b
chr23_+_41831224 0.44 ENSDART00000171885
scp2b
sterol carrier protein 2b
chr23_-_24263474 0.43 ENSDART00000160312
hspb7
heat shock protein family, member 7 (cardiovascular)
chr3_+_26813058 0.39 ENSDART00000055537
socs1a
suppressor of cytokine signaling 1a
chr18_+_49225552 0.39 ENSDART00000135026
si:ch211-136a13.1
si:ch211-136a13.1
chr8_-_32497815 0.39 ENSDART00000122359
si:dkey-164f24.2
si:dkey-164f24.2
chr9_-_35875051 0.38 ENSDART00000013432
dnajc28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr8_-_32497581 0.37 ENSDART00000176298
ENSDART00000183340
si:dkey-164f24.2
si:dkey-164f24.2
chr11_+_40032790 0.36 ENSDART00000158809
si:dkey-264d12.1
si:dkey-264d12.1
chr25_-_31433512 0.35 ENSDART00000067028
zgc:172145
zgc:172145
chr14_-_237130 0.34 ENSDART00000164988
bod1l1
biorientation of chromosomes in cell division 1-like 1
chr22_+_35068046 0.32 ENSDART00000161660
ENSDART00000169573
si:ch73-173h19.3
si:ch73-173h19.3
chr7_-_18508815 0.31 ENSDART00000173539
rgs12a
regulator of G protein signaling 12a
chr7_+_9290929 0.30 ENSDART00000128530
snrpa1
small nuclear ribonucleoprotein polypeptide A'
chr18_+_5549672 0.29 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr7_+_22767678 0.29 ENSDART00000137203
ponzr6
plac8 onzin related protein 6
chr12_-_4070058 0.28 ENSDART00000042200
aldoab
aldolase a, fructose-bisphosphate, b
chr15_+_11427620 0.28 ENSDART00000168688
ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr11_+_77526 0.27 ENSDART00000193521
CABZ01072242.1

chr13_+_33703784 0.26 ENSDART00000173361
macrod2
MACRO domain containing 2
chr9_+_45605410 0.26 ENSDART00000136444
ENSDART00000007189
ENSDART00000158713
ENSDART00000182671
traf3ip1
TNF receptor-associated factor 3 interacting protein 1
chr18_+_25003207 0.25 ENSDART00000099476
ENSDART00000132285
fam174b
family with sequence similarity 174, member B
chr24_-_4768955 0.24 ENSDART00000066834
agtr1b
angiotensin II receptor, type 1b
chr4_-_797831 0.24 ENSDART00000158970
ENSDART00000170012
mapre3b
microtubule-associated protein, RP/EB family, member 3b
chr2_-_42628028 0.24 ENSDART00000179866
myo10
myosin X
chr19_-_43819582 0.23 ENSDART00000160879
ENSDART00000075902
klhl43
kelch-like family member 43
chr2_+_54755172 0.23 ENSDART00000097864
ankrd12
ankyrin repeat domain 12
chr10_-_10018120 0.22 ENSDART00000132375
strbp
spermatid perinuclear RNA binding protein
chr12_+_15165736 0.22 ENSDART00000180398
adprh
ADP-ribosylarginine hydrolase
chr22_+_30446987 0.22 ENSDART00000146471
si:dkey-169i5.4
si:dkey-169i5.4
chr14_-_25949951 0.22 ENSDART00000141304
sparc
secreted protein, acidic, cysteine-rich (osteonectin)
chr14_+_45608576 0.22 ENSDART00000173248
si:ch211-276i12.11
si:ch211-276i12.11
chr19_-_11425542 0.22 ENSDART00000177875
ENSDART00000080762
sept7a
septin 7a
chr3_-_56569968 0.21 ENSDART00000165317
SMIM10
Danio rerio uncharacterized LOC797202 (LOC797202), mRNA.
chr14_-_736575 0.21 ENSDART00000168611
tlr1
toll-like receptor 1
chr15_+_37545855 0.21 ENSDART00000099456
psenen
presenilin enhancer gamma secretase subunit
chr3_-_21242460 0.20 ENSDART00000007293
tcap
titin-cap (telethonin)
chr20_+_23625387 0.20 ENSDART00000147945
ENSDART00000150497
palld
palladin, cytoskeletal associated protein
chr17_-_14671098 0.20 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr8_+_30742898 0.20 ENSDART00000018475
snrpd3
small nuclear ribonucleoprotein D3 polypeptide
chr25_+_32496877 0.19 ENSDART00000132698
ctdspl2a
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr9_-_21904695 0.19 ENSDART00000134768
lmo7a
LIM domain 7a
chr6_+_8172227 0.18 ENSDART00000146106
nfil3-5
nuclear factor, interleukin 3 regulated, member 5
chr5_+_24287927 0.18 ENSDART00000143563
zdhhc23a
zinc finger, DHHC-type containing 23a
chr10_-_34976812 0.18 ENSDART00000170625
smad9
SMAD family member 9
chr9_-_21936841 0.18 ENSDART00000144843
lmo7a
LIM domain 7a
chr21_-_13751535 0.18 ENSDART00000111666
npdc1a
neural proliferation, differentiation and control, 1a
chr23_+_40908583 0.18 ENSDART00000180933
LO017845.1

chr5_+_18047111 0.18 ENSDART00000132164
hira
histone cell cycle regulator a
chr16_+_31542645 0.18 ENSDART00000163724
SLA (1 of many)
Src like adaptor
chr3_-_36846496 0.17 ENSDART00000055237
ramp2
receptor (G protein-coupled) activity modifying protein 2
chr17_+_33433576 0.17 ENSDART00000077581
snap23.2
synaptosomal-associated protein 23.2
chr7_-_72269049 0.17 ENSDART00000161497
CU463038.2

chr25_+_32496723 0.17 ENSDART00000087978
ctdspl2a
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr13_+_23157053 0.17 ENSDART00000162359
sorbs1
sorbin and SH3 domain containing 1
chr18_+_50461981 0.17 ENSDART00000158761
CU896640.1

chr19_-_3574060 0.17 ENSDART00000105120
tmem170b
transmembrane protein 170B
chr2_+_26240339 0.17 ENSDART00000191006
palm1b
paralemmin 1b
chr24_-_37272116 0.16 ENSDART00000022999
ube2ib
ubiquitin-conjugating enzyme E2Ib
chr17_+_50524573 0.16 ENSDART00000187974
CR382385.1

chr23_+_19790962 0.16 ENSDART00000142228
flna
filamin A, alpha (actin binding protein 280)
chr24_-_28245872 0.16 ENSDART00000167861
cox4i1l
cytochrome c oxidase subunit IV isoform 1, like
chr13_+_45980163 0.16 ENSDART00000074547
ENSDART00000005195
bsdc1
BSD domain containing 1
chr7_-_26601307 0.16 ENSDART00000188934
plscr3b
phospholipid scramblase 3b
chr9_+_23900703 0.16 ENSDART00000127859
trim63b
tripartite motif containing 63b
chr23_+_45734011 0.16 ENSDART00000062415
CABZ01088025.1

chr6_-_33925381 0.16 ENSDART00000137268
ENSDART00000145019
ENSDART00000141822
akr1a1b
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr9_-_21230999 0.16 ENSDART00000150160
ENSDART00000102147
pla1a
phospholipase A1 member A
chr19_-_5369486 0.16 ENSDART00000105004
krt17
keratin 17
chr3_-_29928695 0.15 ENSDART00000151275
ENSDART00000151083
grna
granulin a
chr19_+_20177208 0.15 ENSDART00000166807
tra2a
transformer 2 alpha homolog
chr6_-_15653494 0.15 ENSDART00000038133
trim63a
tripartite motif containing 63a
chr4_+_76957765 0.15 ENSDART00000129607
si:dkey-240n22.6
si:dkey-240n22.6
chr1_+_59073203 0.15 ENSDART00000149937
ENSDART00000162201
MFAP4 (1 of many)
zgc:173915
si:zfos-2330d3.3
zgc:173915
chr13_+_281214 0.15 ENSDART00000137572
mpc1
mitochondrial pyruvate carrier 1
chr19_+_46113828 0.15 ENSDART00000159331
ENSDART00000161826
rbm24a
RNA binding motif protein 24a
chr21_-_17603182 0.15 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr5_-_25583125 0.15 ENSDART00000031665
ENSDART00000145353
anxa1a
annexin A1a
chr6_-_29195642 0.15 ENSDART00000078625
dpt
dermatopontin
chr19_+_4061699 0.15 ENSDART00000158309
ENSDART00000166512
btr25
btr26
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr13_+_22295905 0.14 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr15_+_28106498 0.14 ENSDART00000041707
unc119a
unc-119 homolog a (C. elegans)
chr2_-_59265521 0.14 ENSDART00000146341
ENSDART00000097799
ftr33
finTRIM family, member 33
chr10_-_24759616 0.14 ENSDART00000079528
ilk
integrin-linked kinase
chr20_+_35085224 0.14 ENSDART00000040456
cdc42bpab
CDC42 binding protein kinase alpha (DMPK-like) b
chr8_+_554531 0.14 ENSDART00000193623
FO704758.2

chr18_-_14337065 0.14 ENSDART00000135703
hsbp1b
heat shock factor binding protein 1b
chr5_+_3892551 0.14 ENSDART00000134396
rpain
RPA interacting protein
chr6_-_52757276 0.14 ENSDART00000159154
AL954861.2

chr4_-_76488581 0.14 ENSDART00000174291
ftr51
finTRIM family, member 51
chr16_-_13595027 0.14 ENSDART00000060004
ntd5
ntl-dependent gene 5
chr6_-_35439406 0.14 ENSDART00000073784
rgs5a
regulator of G protein signaling 5a
chr16_+_40340222 0.14 ENSDART00000190631
mettl6
methyltransferase like 6
chr25_-_27819838 0.14 ENSDART00000067106
lmod2a
leiomodin 2 (cardiac) a
chr4_+_70351760 0.13 ENSDART00000159832
si:dkey-190j3.6
si:dkey-190j3.6
chr14_+_6546516 0.13 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr14_-_12307522 0.13 ENSDART00000163900
myot
myotilin
chr22_-_11136625 0.13 ENSDART00000016873
ENSDART00000125561
atp6ap2
ATPase H+ transporting accessory protein 2
chr19_-_43757568 0.13 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr14_+_51098036 0.13 ENSDART00000184118
CABZ01078594.1

chr20_-_7293837 0.13 ENSDART00000100060
dsc2l
desmocollin 2 like
chr4_+_5156117 0.13 ENSDART00000067392
tigarb
tp53-induced glycolysis and apoptosis regulator b
chr11_-_3646793 0.13 ENSDART00000077344
itih1
inter-alpha-trypsin inhibitor heavy chain 1
chr16_+_40301056 0.13 ENSDART00000058578
rspo3
R-spondin 3
chr20_+_26349002 0.13 ENSDART00000152842
syne1a
spectrin repeat containing, nuclear envelope 1a
chr10_+_5268054 0.13 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr25_-_3892686 0.13 ENSDART00000043172
tmem258
transmembrane protein 258
chr24_+_6353394 0.13 ENSDART00000165118
CR352329.1

chr6_-_55423220 0.13 ENSDART00000158929
ctsa
cathepsin A
chr19_+_4068134 0.12 ENSDART00000158285
btr26
bloodthirsty-related gene family, member 26
chr8_-_26388090 0.12 ENSDART00000147912
si:dkey-20d21.12
si:dkey-20d21.12
chr6_-_42049350 0.12 ENSDART00000022949
parp3
poly (ADP-ribose) polymerase family, member 3
chr8_-_2230128 0.12 ENSDART00000140427
si:dkeyp-117b11.2
si:dkeyp-117b11.2
chr13_+_22480496 0.12 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
ldb3a
LIM domain binding 3a
chr23_-_874418 0.12 ENSDART00000133906
rbm10
RNA binding motif protein 10
chr17_-_52091999 0.12 ENSDART00000019766
tgfb3
transforming growth factor, beta 3
chr13_+_23176330 0.12 ENSDART00000168351
sorbs1
sorbin and SH3 domain containing 1
chr20_-_15922986 0.11 ENSDART00000189421
fam20b
family with sequence similarity 20, member B (H. sapiens)
chr17_+_53311618 0.11 ENSDART00000166517
asb2b
ankyrin repeat and SOCS box containing 2b
chr12_+_48581588 0.11 ENSDART00000114996
CABZ01078415.1

chr24_-_12958668 0.11 ENSDART00000178982
FITM1 (1 of many)
Danio rerio fat storage inducing transmembrane protein 1 (LOC792443), mRNA.
chr4_+_11458078 0.11 ENSDART00000037600
ankrd16
ankyrin repeat domain 16
chr11_-_3647014 0.11 ENSDART00000171786
itih1
inter-alpha-trypsin inhibitor heavy chain 1
chr15_-_47468085 0.11 ENSDART00000164438
inppl1a
inositol polyphosphate phosphatase-like 1a
chr11_+_141504 0.11 ENSDART00000086166
NCKAP1L
zgc:172352
chr4_+_41602 0.11 ENSDART00000159640
phtf2
putative homeodomain transcription factor 2
chr7_-_25895189 0.11 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr22_-_506522 0.11 ENSDART00000106645
ENSDART00000067637
dstyk
dual serine/threonine and tyrosine protein kinase
chr25_+_37340722 0.11 ENSDART00000137025
pamr1
peptidase domain containing associated with muscle regeneration 1
chr6_+_49881864 0.11 ENSDART00000075040
tubb1
tubulin, beta 1 class VI
chr9_-_34191627 0.11 ENSDART00000142664
dcaf6
ddb1 and cul4 associated factor 6
chr1_-_9104631 0.11 ENSDART00000146642
si:ch211-14k19.8
si:ch211-14k19.8
chr14_+_2243 0.11 ENSDART00000191193
CYTL1
cytokine like 1
chr18_-_49020066 0.11 ENSDART00000174394
BX663503.3

chr6_-_24103666 0.11 ENSDART00000164915
scinla
scinderin like a
chr24_-_28306484 0.11 ENSDART00000148618
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr3_-_1434135 0.11 ENSDART00000149622
mgp
matrix Gla protein
chr13_+_22480857 0.11 ENSDART00000078721
ENSDART00000044719
ENSDART00000130957
ENSDART00000078757
ENSDART00000130424
ENSDART00000078747
ldb3a
LIM domain binding 3a
chr5_+_36661058 0.11 ENSDART00000125653
capns1a
calpain, small subunit 1 a
chr6_+_60036767 0.10 ENSDART00000155009
tgm8
transglutaminase 8
chr17_+_23968214 0.10 ENSDART00000183053
xpo1b
exportin 1 (CRM1 homolog, yeast) b
chr11_-_44647286 0.10 ENSDART00000169329
ENSDART00000158939
tomm20b
translocase of outer mitochondrial membrane 20b
chr3_+_28594713 0.10 ENSDART00000179799
sept12
septin 12
chr19_-_7144548 0.10 ENSDART00000147177
ENSDART00000134850
psmb8a
psmb13a
proteasome subunit beta 8A
proteasome subunit beta 13a
chr14_-_29799993 0.10 ENSDART00000133775
ENSDART00000005568
pdlim3b
PDZ and LIM domain 3b
chr2_-_42128714 0.10 ENSDART00000047055
trim55a
tripartite motif containing 55a
chr12_+_8822717 0.10 ENSDART00000021628
reep3b
receptor accessory protein 3b
chr9_-_23922011 0.10 ENSDART00000145734
col6a3
collagen, type VI, alpha 3
chr24_+_41610068 0.10 ENSDART00000159507
CABZ01044108.1

chr18_-_5509616 0.10 ENSDART00000142945
bloc1s6
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
chr8_+_22359881 0.10 ENSDART00000187867
zgc:153631
zgc:153631
chr10_-_43334914 0.10 ENSDART00000146660
ENSDART00000190288
hapln1b
hyaluronan and proteoglycan link protein 1b
chr6_+_41463786 0.10 ENSDART00000065006
twf2a
twinfilin actin-binding protein 2a
chr16_-_39859119 0.10 ENSDART00000138388
rbms3
RNA binding motif, single stranded interacting protein
chr19_-_32487469 0.10 ENSDART00000050130
gmpr
guanosine monophosphate reductase
chr13_+_42124566 0.10 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr9_+_24095677 0.10 ENSDART00000150443
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr2_-_43135700 0.10 ENSDART00000098284
ftr14
finTRIM family, member 14
chr14_+_9421510 0.10 ENSDART00000123652
hmgn6
high mobility group nucleosome binding domain 6
chr14_-_34700633 0.10 ENSDART00000150358
ablim3
actin binding LIM protein family, member 3
chr22_-_30935510 0.10 ENSDART00000133335
si:dkey-49n23.1
si:dkey-49n23.1
chr20_+_34151670 0.10 ENSDART00000152870
ENSDART00000010329
ENSDART00000145852
arpc5b
actin related protein 2/3 complex, subunit 5B
chr15_-_419597 0.10 ENSDART00000058993
psph
phosphoserine phosphatase
chr12_-_628024 0.10 ENSDART00000158563
ENSDART00000152612
wu:fj29h11
si:ch73-301j1.1
wu:fj29h11
si:ch73-301j1.1
chr12_-_9132682 0.10 ENSDART00000066471
adam8b
ADAM metallopeptidase domain 8b
chr18_-_44129151 0.10 ENSDART00000087339
cdon
cell adhesion associated, oncogene regulated
chr23_-_27479558 0.09 ENSDART00000013563
atf7a
activating transcription factor 7a
chr23_+_25893020 0.09 ENSDART00000144769
pkig
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr5_+_8964926 0.09 ENSDART00000091397
ENSDART00000164535
tnksb
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b
chr4_+_50401133 0.09 ENSDART00000150644
si:dkey-156k2.7
si:dkey-156k2.7
chr19_-_38611814 0.09 ENSDART00000151958
col16a1
collagen, type XVI, alpha 1
chr12_-_5505205 0.09 ENSDART00000092319
abi3b
ABI family, member 3b
chr19_-_24218942 0.09 ENSDART00000189198
BX547993.2

chr20_+_54356540 0.09 ENSDART00000143591
znf410
zinc finger protein 410
chr19_-_12193622 0.09 ENSDART00000041960
ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr5_-_26466169 0.09 ENSDART00000144035
arvcfb
ARVCF, delta catenin family member b
chr18_+_8912113 0.09 ENSDART00000147467
tmem243a
transmembrane protein 243, mitochondrial a
chr2_-_43151358 0.09 ENSDART00000061170
ENSDART00000056161
ftr15
finTRIM family, member 15
chr22_+_81799 0.09 ENSDART00000163661
zgc:112334
zgc:112334
chr21_-_45728069 0.09 ENSDART00000185101
CU302316.1

chr20_-_15922210 0.09 ENSDART00000152412
ENSDART00000152354
ENSDART00000152828
ENSDART00000013453
ENSDART00000152357
fam20b
family with sequence similarity 20, member B (H. sapiens)

Network of associatons between targets according to the STRING database.

First level regulatory network of smad2_smad10a+smad4a_smad1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.4 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.1 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.4 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.2 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0043455 regulation of secondary metabolic process(GO:0043455)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.2 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.0 0.3 GO:0031113 regulation of microtubule polymerization(GO:0031113) cerebrospinal fluid circulation(GO:0090660)
0.0 0.6 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:0090024 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.0 0.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 1.5 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.2 GO:0045064 T-helper 2 cell differentiation(GO:0045064)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.5 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0032206 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.0 0.2 GO:0034205 Notch receptor processing(GO:0007220) beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.7 GO:0007631 feeding behavior(GO:0007631)
0.0 0.1 GO:0035989 tendon development(GO:0035989)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.1 GO:0051031 tRNA transport(GO:0051031)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 0.1 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:1903723 negative regulation of centriole elongation(GO:1903723)
0.0 0.1 GO:0010660 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.0 0.1 GO:0033632 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.1 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.2 GO:2000403 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.2 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.0 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.0 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.0 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0060036 notochord cell vacuolation(GO:0060036)
0.0 0.1 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.0 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.0 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.0 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.0 GO:0065001 specification of axis polarity(GO:0065001)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.6 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.0 GO:0008352 katanin complex(GO:0008352)
0.0 0.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.0 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.7 GO:0042641 actomyosin(GO:0042641)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.0 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.2 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1 0.3 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.1 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:1990825 mRNA CDS binding(GO:1990715) sequence-specific mRNA binding(GO:1990825)
0.0 0.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.5 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.1 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.0 1.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.0 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.1 GO:0051380 norepinephrine binding(GO:0051380)
0.0 0.0 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.0 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.0 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.0 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions