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PRJNA207719: Tissue specific transcriptome profiling
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Results for sox19a+sox2
Z-value: 3.38
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Transcription factors associated with sox19a+sox2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sox19a | dr11_v1_chr5_-_24201437_24201437 | 0.98 | 4.7e-03 | Click! |
| sox2 | dr11_v1_chr22_-_37349967_37349967 | 0.92 | 2.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_17745345 Show fit | 3.54 |
ENSDART00000132690
ENSDART00000135376 |
si:dkey-200l5.4 |
|
| chr11_+_25735478 Show fit | 3.02 |
ENSDART00000103566
|
si:dkey-183j2.10 |
|
| chr14_-_33872092 Show fit | 3.01 |
ENSDART00000111903
|
si:ch73-335m24.2 |
|
| chr6_-_43092175 Show fit | 2.58 |
ENSDART00000084389
|
leucine rich repeat neuronal 1 |
|
| chr11_+_35364445 Show fit | 2.56 |
ENSDART00000125766
|
CaM kinase-like vesicle-associated b |
|
| chr19_-_21832441 Show fit | 2.37 |
ENSDART00000151272
ENSDART00000151442 ENSDART00000150168 ENSDART00000148797 ENSDART00000128196 ENSDART00000149259 ENSDART00000052556 ENSDART00000149658 ENSDART00000149639 ENSDART00000148424 |
myelin basic protein a |
|
| chr6_+_27146671 Show fit | 2.25 |
ENSDART00000156792
|
kinesin family member 1Aa |
|
| chr19_+_43017931 Show fit | 2.19 |
ENSDART00000132213
|
sodium/potassium transporting ATPase interacting 1 |
|
| chr2_+_3472832 Show fit | 2.17 |
ENSDART00000115278
|
connexin 47.1 |
|
| chr2_-_21082695 Show fit | 2.03 |
ENSDART00000032502
|
nebulette |
Network of associatons between targets according to the STRING database.
First level regulatory network of sox19a+sox2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 10.8 | GO:0031175 | neuron projection development(GO:0031175) |
| 0.0 | 7.6 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter(GO:0045944) |
| 0.1 | 7.4 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.0 | 6.3 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 5.9 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.3 | 5.8 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.2 | 5.7 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 5.4 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 4.8 | GO:0090630 | activation of GTPase activity(GO:0090630) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 17.6 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 8.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 8.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 7.0 | GO:0036477 | somatodendritic compartment(GO:0036477) |
| 0.1 | 6.7 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.0 | 6.1 | GO:0031410 | cytoplasmic vesicle(GO:0031410) |
| 0.1 | 5.1 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 4.9 | GO:0005874 | microtubule(GO:0005874) |
| 0.3 | 4.5 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 13.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 11.1 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 10.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 5.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 4.7 | GO:0101005 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.1 | 4.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 3.7 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 2.9 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.3 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 2.0 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.8 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.4 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 1.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.8 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 2.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.9 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 1.7 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 1.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 1.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |