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PRJNA207719: Tissue specific transcriptome profiling

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Results for sox8a+sox8b

Z-value: 0.39

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Transcription factors associated with sox8a+sox8b

Gene Symbol Gene ID Gene Info
sox8b
ENSDARG00000037782 SRY-box transcription factor 8b
sox8a
ENSDARG00000105301 SRY-box transcription factor 8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox8adr11_v1_chr12_-_1085227_10852270.592.9e-01Click!
sox8bdr11_v1_chr3_-_62403550_62403550-0.454.5e-01Click!

Activity profile of sox8a+sox8b motif

Sorted Z-values of sox8a+sox8b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_4890693 0.30 ENSDART00000023537
tnnc1a
troponin C type 1a (slow)
chr23_-_35694171 0.25 ENSDART00000077539
tuba1c
tubulin, alpha 1c
chr10_+_5268054 0.16 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr19_+_33553586 0.16 ENSDART00000183477
runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_-_39273987 0.15 ENSDART00000127173
clu
clusterin
chr7_+_73780936 0.14 ENSDART00000092691
pea15
proliferation and apoptosis adaptor protein 15
chr2_+_9946121 0.13 ENSDART00000100696
tsen15
TSEN15 tRNA splicing endonuclease subunit
chr12_-_33359654 0.13 ENSDART00000001907
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr20_-_39273505 0.13 ENSDART00000153114
clu
clusterin
chr19_+_27448625 0.13 ENSDART00000052352
ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr12_-_33359052 0.12 ENSDART00000135943
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr10_-_43334914 0.12 ENSDART00000146660
ENSDART00000190288
hapln1b
hyaluronan and proteoglycan link protein 1b
chr23_-_27235403 0.12 ENSDART00000134418
si:dkey-157g16.6
si:dkey-157g16.6
chr2_+_23222939 0.12 ENSDART00000026800
kifap3b
kinesin-associated protein 3b
chr14_+_6546516 0.11 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr1_+_25801648 0.11 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr7_-_52849913 0.10 ENSDART00000174133
ENSDART00000172951
map1aa
microtubule-associated protein 1Aa
chr9_-_43538328 0.10 ENSDART00000140526
znf385b
zinc finger protein 385B
chr19_-_27448606 0.09 ENSDART00000079251
vars2
valyl-tRNA synthetase 2, mitochondrial (putative)
chr11_-_43226255 0.09 ENSDART00000172929
sptbn1
spectrin, beta, non-erythrocytic 1
chr13_-_44423 0.09 ENSDART00000093247
gtf2a1l
general transcription factor IIA, 1-like
chr12_+_30705769 0.09 ENSDART00000186448
ENSDART00000066259
kcnk1a
potassium channel, subfamily K, member 1a
chr22_-_38621438 0.09 ENSDART00000098330
nppc
natriuretic peptide C
chr19_+_11432330 0.09 ENSDART00000188065
PQLC1
PQ loop repeat containing 1
chr12_-_11593436 0.09 ENSDART00000138954
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr20_-_29505863 0.08 ENSDART00000148278
klf11a
Kruppel-like factor 11a
chr7_+_25003851 0.08 ENSDART00000144526
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr12_+_30706158 0.08 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr16_+_25095483 0.08 ENSDART00000155032
si:ch211-261d7.3
si:ch211-261d7.3
chr19_+_12801940 0.08 ENSDART00000040073
mc5ra
melanocortin 5a receptor
chr24_-_21923930 0.08 ENSDART00000131944
tagln3b
transgelin 3b
chr21_+_43669943 0.08 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr9_-_3034064 0.08 ENSDART00000115138
ENSDART00000144046
rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr23_+_17878969 0.08 ENSDART00000154934
ENSDART00000154140
ENSDART00000156331
si:ch73-390p7.2
si:ch73-390p7.2
chr20_-_37522569 0.08 ENSDART00000177011
ENSDART00000058502
hivep2a
human immunodeficiency virus type I enhancer binding protein 2a
chr17_+_24687338 0.08 ENSDART00000135794
selenon
selenoprotein N
chr1_+_38362412 0.07 ENSDART00000075086
cep44
centrosomal protein 44
chr16_-_21047872 0.07 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr18_-_20869175 0.07 ENSDART00000090079
synm
synemin, intermediate filament protein
chr21_+_39705483 0.07 ENSDART00000147718
ENSDART00000168996
plrdgb
PITP-less RdgB-like protein
chr5_+_41146786 0.07 ENSDART00000175766
sub1b
SUB1 homolog, transcriptional regulator b
chr11_-_30138299 0.07 ENSDART00000172106
scml2
Scm polycomb group protein like 2
chr3_-_5067585 0.07 ENSDART00000169609
tefb
thyrotrophic embryonic factor b
chr21_+_32820175 0.07 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr7_+_17096281 0.07 ENSDART00000035558
htatip2
HIV-1 Tat interactive protein 2
chr10_-_22249444 0.06 ENSDART00000148831
fgf11b
fibroblast growth factor 11b
chr20_+_30578967 0.06 ENSDART00000010494
fgfr1op
FGFR1 oncogene partner
chr10_+_15967643 0.06 ENSDART00000136709
apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr5_-_54300725 0.06 ENSDART00000163048
slc25a35
solute carrier family 25, member 35
chr9_+_17423941 0.06 ENSDART00000112884
ENSDART00000155233
kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr17_+_24604373 0.06 ENSDART00000082193
zmpste24
zinc metallopeptidase, STE24 homolog
chr17_+_14784275 0.06 ENSDART00000005355
rtraf
RNA transcription, translation and transport factor
chr21_+_34088377 0.06 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr12_+_18544159 0.06 ENSDART00000162900
mlst8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr14_+_597532 0.05 ENSDART00000159805
LO018568.2

chr3_+_32663865 0.05 ENSDART00000190240
si:dkey-16l2.16
si:dkey-16l2.16
chr11_-_18015534 0.05 ENSDART00000181953
qrich1
glutamine-rich 1
chr10_-_14545658 0.05 ENSDART00000057865
ier3ip1
immediate early response 3 interacting protein 1
chr9_+_41156818 0.05 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr11_+_30254556 0.05 ENSDART00000182316
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr23_-_36418708 0.04 ENSDART00000132273
znf740b
zinc finger protein 740b
chr17_+_38476300 0.04 ENSDART00000123298
stard9
StAR-related lipid transfer (START) domain containing 9
chr18_+_5917625 0.04 ENSDART00000169100
glg1b
golgi glycoprotein 1b
chr9_+_23714406 0.04 ENSDART00000189445
gypc
glycophorin C (Gerbich blood group)
chr19_-_11950434 0.04 ENSDART00000024861
cpsf1
cleavage and polyadenylation specific factor 1
chr21_-_13535601 0.04 ENSDART00000139568
nsmfa
NMDA receptor synaptonuclear signaling and neuronal migration factor a
chr3_-_59981476 0.04 ENSDART00000035878
ENSDART00000124038
cdr2l
cerebellar degeneration-related protein 2-like
chr19_-_11949996 0.04 ENSDART00000163478
ENSDART00000167299
cpsf1
cleavage and polyadenylation specific factor 1
chr24_-_41220538 0.03 ENSDART00000150207
acvr2ba
activin A receptor type 2Ba
chr16_-_21047483 0.03 ENSDART00000136235
cbx3b
chromobox homolog 3b
chr24_-_3304664 0.03 ENSDART00000183168
sugct
succinyl-CoA:glutarate-CoA transferase
chr15_-_9419472 0.03 ENSDART00000122117
sacs
sacsin molecular chaperone
chr25_-_37248795 0.03 ENSDART00000087247
ENSDART00000154045
glg1a
golgi glycoprotein 1a
chr3_-_59981162 0.03 ENSDART00000128790
cdr2l
cerebellar degeneration-related protein 2-like
chr7_-_50410524 0.03 ENSDART00000083346
hypk
huntingtin interacting protein K
chr5_+_45138934 0.03 ENSDART00000041412
ENSDART00000136002
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_-_8892514 0.03 ENSDART00000144553
plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr2_+_51645164 0.03 ENSDART00000169600
abhd4
abhydrolase domain containing 4
chr3_+_41726360 0.03 ENSDART00000154401
chst12a
carbohydrate (chondroitin 4) sulfotransferase 12a
chr8_+_41238064 0.03 ENSDART00000111321
zgc:152830
zgc:152830
chr1_-_16688965 0.03 ENSDART00000079001
ENSDART00000178599
frg1
FSHD region gene 1
chr22_-_817479 0.03 ENSDART00000123487
zgc:153675
zgc:153675
chr8_-_14052349 0.02 ENSDART00000135811
atp2b3a
ATPase plasma membrane Ca2+ transporting 3a
chr7_-_18547420 0.02 ENSDART00000173969
rgs12a
regulator of G protein signaling 12a
chr10_+_7709724 0.02 ENSDART00000097670
ggcx
gamma-glutamyl carboxylase
chr20_+_54383838 0.02 ENSDART00000157737
lrfn5b
leucine rich repeat and fibronectin type III domain containing 5b
chr8_+_10862353 0.02 ENSDART00000140717
brpf3b
bromodomain and PHD finger containing, 3b
chr10_+_11398111 0.02 ENSDART00000064210
cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr19_+_3653976 0.02 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr10_+_9595575 0.02 ENSDART00000091780
ENSDART00000184287
rc3h2
ring finger and CCCH-type domains 2
chr1_+_6646529 0.02 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr15_+_3125136 0.02 ENSDART00000130968
rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr16_+_46111849 0.02 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr3_+_62327332 0.01 ENSDART00000158414
BX470259.1

chr7_+_52753067 0.01 ENSDART00000053814
mtfmt
mitochondrial methionyl-tRNA formyltransferase
chr24_-_33873451 0.01 ENSDART00000159840
asic1c
acid-sensing (proton-gated) ion channel 1c
chr11_+_13176568 0.01 ENSDART00000125371
ENSDART00000123257
mknk1
MAP kinase interacting serine/threonine kinase 1
chr3_+_39579393 0.01 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr9_-_23147026 0.01 ENSDART00000167266
lypd6b
LY6/PLAUR domain containing 6B
chr15_-_43327911 0.01 ENSDART00000077386
prss16
protease, serine, 16 (thymus)
chr4_+_6833583 0.01 ENSDART00000165179
ENSDART00000186134
ENSDART00000174507
dock4b
dedicator of cytokinesis 4b
chr20_-_3276339 0.00 ENSDART00000166831
rps6kc1
ribosomal protein S6 kinase polypeptide 1
chr21_+_34088110 0.00 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr22_+_9522971 0.00 ENSDART00000110048
strip1
striatin interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of sox8a+sox8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway