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PRJNA207719: Tissue specific transcriptome profiling
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Results for spi1a+spi1b
Z-value: 4.41
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Transcription factors associated with spi1a+spi1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| spi1b | dr11_v1_chr7_-_32659048_32659048 | 0.78 | 1.2e-01 | Click! |
| spi1a | dr11_v1_chr25_+_35553542_35553542 | 0.58 | 3.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_10177442 Show fit | 4.26 |
ENSDART00000144280
ENSDART00000129044 |
keratin 5 |
|
| chr3_+_40809011 Show fit | 3.23 |
ENSDART00000033713
|
actin related protein 2/3 complex, subunit 1B |
|
| chr20_+_38285671 Show fit | 2.73 |
ENSDART00000061432
|
chemokine (C-C motif) ligand 38, duplicate 4 |
|
| chr15_-_29598679 Show fit | 2.58 |
ENSDART00000155153
|
si:ch211-207n23.2 |
|
| chr3_-_30941362 Show fit | 2.53 |
ENSDART00000076830
|
coronin, actin binding protein, 1A |
|
| chr6_-_49063085 Show fit | 2.41 |
ENSDART00000156124
|
si:ch211-105j21.9 |
|
| chr15_+_20239141 Show fit | 2.39 |
ENSDART00000101152
ENSDART00000152473 |
serine peptidase inhibitor, Kunitz type, 2 |
|
| chr23_+_44599012 Show fit | 2.30 |
ENSDART00000125198
|
profilin 1 |
|
| chr5_+_43783360 Show fit | 2.29 |
ENSDART00000019431
|
nitric oxide synthase 2a, inducible |
|
| chr10_+_2669405 Show fit | 2.19 |
ENSDART00000110202
|
chemokine (C-C motif) ligand 27b |
Network of associatons between targets according to the STRING database.
First level regulatory network of spi1a+spi1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.5 | GO:0006955 | immune response(GO:0006955) |
| 0.0 | 11.4 | GO:0006412 | translation(GO:0006412) |
| 0.2 | 7.0 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 0.3 | 6.3 | GO:0002574 | thrombocyte differentiation(GO:0002574) |
| 0.2 | 5.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 4.9 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.1 | 4.8 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.1 | 3.6 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 3.4 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.1 | 2.6 | GO:0051639 | actin filament network formation(GO:0051639) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 11.1 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 8.9 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 8.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 7.6 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.4 | 6.6 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 5.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 4.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 4.4 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 4.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 18.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 10.2 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 8.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 6.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 5.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 4.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.2 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 3.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 3.3 | GO:0019901 | protein kinase binding(GO:0019901) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 5.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 5.3 | PID EPO PATHWAY | EPO signaling pathway |
| 0.2 | 4.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 3.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.0 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 7.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 5.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 3.3 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 3.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.0 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.2 | 2.6 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.3 | 2.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |