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PRJNA207719: Tissue specific transcriptome profiling
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Results for spi2+spic
Z-value: 4.34
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Transcription factors associated with spi2+spic
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| spic | dr11_v1_chr4_-_17812131_17812131 | 0.78 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_18626515 Show fit | 3.18 |
ENSDART00000160624
|
ribosomal protein S18 |
|
| chr16_+_20934353 Show fit | 2.88 |
ENSDART00000052660
|
src kinase associated phosphoprotein 2 |
|
| chr5_-_25582721 Show fit | 2.83 |
ENSDART00000123986
|
annexin A1a |
|
| chr4_-_22310956 Show fit | 2.79 |
ENSDART00000162585
|
hematopoietic cell-specific Lyn substrate 1 |
|
| chr5_-_25583125 Show fit | 2.73 |
ENSDART00000031665
ENSDART00000145353 |
annexin A1a |
|
| chr10_-_15128771 Show fit | 2.70 |
ENSDART00000101261
|
secreted phosphoprotein 1 |
|
| chr22_+_5478353 Show fit | 2.68 |
ENSDART00000160596
|
tubulin polymerization promoting protein |
|
| chr9_+_21165017 Show fit | 2.52 |
ENSDART00000145933
ENSDART00000142985 |
si:rp71-68n21.9 |
|
| chr3_+_29510818 Show fit | 2.45 |
ENSDART00000055407
ENSDART00000193743 ENSDART00000123619 |
Rac family small GTPase 2 |
|
| chr23_+_39089574 Show fit | 2.43 |
ENSDART00000164711
|
nuclear factor of activated T cells 2a |
Network of associatons between targets according to the STRING database.
First level regulatory network of spi2+spic
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0006955 | immune response(GO:0006955) |
| 0.1 | 6.7 | GO:0006956 | complement activation(GO:0006956) |
| 0.0 | 6.5 | GO:0006412 | translation(GO:0006412) |
| 0.0 | 5.9 | GO:0032970 | regulation of actin filament-based process(GO:0032970) |
| 0.0 | 5.8 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.9 | 5.6 | GO:0045627 | neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.1 | 5.0 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 4.7 | GO:0060326 | cell chemotaxis(GO:0060326) |
| 0.1 | 3.9 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.1 | 2.8 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity(GO:0051092) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 14.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 7.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 6.8 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 5.8 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.4 | 5.6 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 5.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 4.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 2.9 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 1.9 | GO:0060170 | ciliary membrane(GO:0060170) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 8.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 6.8 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 5.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 5.6 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 5.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 5.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 4.3 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.2 | 3.5 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 3.5 | GO:0019957 | C-C chemokine binding(GO:0019957) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 2.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.0 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 2.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 1.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 1.9 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 1.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.6 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.5 | 4.0 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 2.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.8 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 2.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 2.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 2.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 2.1 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.3 | 1.9 | REACTOME OPSINS | Genes involved in Opsins |