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PRJNA207719: Tissue specific transcriptome profiling
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Results for tbp
Z-value: 3.30
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Transcription factors associated with tbp
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tbp | dr11_v1_chr13_-_24396199_24396199 | -0.75 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_33081978 Show fit | 3.64 |
ENSDART00000100918
|
zgc:172053 |
|
| chr18_-_5527050 Show fit | 3.29 |
ENSDART00000145400
ENSDART00000132498 ENSDART00000146209 |
zgc:153317 |
|
| chr23_-_10177442 Show fit | 3.08 |
ENSDART00000144280
ENSDART00000129044 |
keratin 5 |
|
| chr9_-_33081781 Show fit | 3.04 |
ENSDART00000165748
|
zgc:172053 |
|
| chr3_-_32818607 Show fit | 2.97 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr1_-_59169815 Show fit | 2.84 |
ENSDART00000100163
|
wu:fk65c09 |
|
| chr9_-_33062891 Show fit | 2.83 |
ENSDART00000161182
|
si:ch211-125e6.5 |
|
| chr9_-_33063083 Show fit | 2.82 |
ENSDART00000048550
|
si:ch211-125e6.5 |
|
| chr21_+_25221940 Show fit | 2.62 |
ENSDART00000108972
|
syncollin, tandem duplicate 1 |
|
| chr21_+_5531138 Show fit | 2.57 |
ENSDART00000163825
|
lymphocyte antigen 6 family member M6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tbp
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.2 | 3.8 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 3.6 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.1 | 3.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.4 | 2.8 | GO:0046292 | formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294) |
| 0.1 | 2.7 | GO:0060030 | dorsal convergence(GO:0060030) |
| 0.2 | 2.5 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.2 | 2.5 | GO:0006603 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.1 | 2.3 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.4 | 2.2 | GO:0031394 | neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 5.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 4.4 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 4.1 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.2 | 3.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.3 | 3.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 3.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.9 | 2.6 | GO:0098556 | cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556) |
| 0.0 | 2.5 | GO:0022626 | cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626) |
| 0.1 | 2.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 3.8 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.1 | 3.3 | GO:0016675 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 3.2 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.7 | 2.9 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 0.0 | 2.9 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.6 | 2.8 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903) |
| 0.2 | 2.6 | GO:0031729 | CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) |
| 0.2 | 2.5 | GO:0004111 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 1.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 1.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 0.5 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 2.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 1.7 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 1.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 1.4 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 1.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |