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PRJNA207719: Tissue specific transcriptome profiling
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Results for tcf3a+tcf3b
Z-value: 1.62
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Transcription factors associated with tcf3a+tcf3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tcf3a | dr11_v1_chr2_-_57378748_57378748 | -0.55 | 3.3e-01 | Click! |
| tcf3b | dr11_v1_chr22_-_20342260_20342260 | -0.03 | 9.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_11756040 Show fit | 1.71 |
ENSDART00000105808
|
keratin 97 |
|
| chr22_+_11775269 Show fit | 1.01 |
ENSDART00000140272
|
keratin 96 |
|
| chr23_-_5683147 Show fit | 0.93 |
ENSDART00000102766
ENSDART00000067351 |
troponin T type 2a (cardiac) |
|
| chr8_+_1009831 Show fit | 0.79 |
ENSDART00000172414
|
fatty acid binding protein 1b, liver, tandem duplicate 2 |
|
| chr23_+_25893020 Show fit | 0.75 |
ENSDART00000144769
|
protein kinase (cAMP-dependent, catalytic) inhibitor gamma |
|
| chr13_-_438705 Show fit | 0.74 |
ENSDART00000082142
|
|
|
| chr14_+_31651533 Show fit | 0.72 |
ENSDART00000172835
|
four and a half LIM domains 1a |
|
| chr22_-_10541372 Show fit | 0.71 |
ENSDART00000179708
|
si:dkey-42i9.4 |
|
| chr7_+_31838320 Show fit | 0.70 |
ENSDART00000144679
ENSDART00000174217 ENSDART00000122506 |
myosin binding protein C, cardiac |
|
| chr4_-_4834347 Show fit | 0.69 |
ENSDART00000141803
|
cytochrome c oxidase assembly factor 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tcf3a+tcf3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0006958 | humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958) |
| 0.0 | 1.7 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.3 | 1.3 | GO:0003228 | atrial cardiac muscle tissue development(GO:0003228) |
| 0.3 | 1.3 | GO:0003210 | cardiac atrium formation(GO:0003210) |
| 0.2 | 1.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.2 | 1.3 | GO:0003209 | cardiac atrium morphogenesis(GO:0003209) |
| 0.1 | 1.2 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 0.0 | 1.2 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 1.1 | GO:0008285 | negative regulation of cell proliferation(GO:0008285) |
| 0.1 | 1.0 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 2.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 1.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.9 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.0 | 1.5 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 1.4 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.7 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 0.6 | GO:0005839 | proteasome core complex(GO:0005839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 1.3 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 1.3 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 1.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 1.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 0.9 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.1 | 0.9 | GO:0030172 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.1 | 0.8 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.9 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.5 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.8 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.0 | 0.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 0.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 0.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |