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PRJNA207719: Tissue specific transcriptome profiling

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Results for tfap2b

Z-value: 1.26

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Transcription factors associated with tfap2b

Gene Symbol Gene ID Gene Info
tfap2b
ENSDARG00000012667 transcription factor AP-2 beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2bdr11_v1_chr20_-_47704973_477049730.385.2e-01Click!

Activity profile of tfap2b motif

Sorted Z-values of tfap2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_26612401 0.71 ENSDART00000145571
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr21_+_26748141 0.65 ENSDART00000169025
pcxa
pyruvate carboxylase a
chr3_+_15271943 0.57 ENSDART00000141752
asphd1
aspartate beta-hydroxylase domain containing 1
chr15_-_32131 0.54 ENSDART00000099074
ENSDART00000164323
CYP2C9
si:zfos-411a11.2
chr7_+_34794829 0.52 ENSDART00000009698
ENSDART00000075089
ENSDART00000173456
esrp2
epithelial splicing regulatory protein 2
chr4_-_77551860 0.46 ENSDART00000188176
AL935186.6

chr15_-_20710 0.43 ENSDART00000161218
cyp2y3
cytochrome P450, family 2, subfamily Y, polypeptide 3
chr4_-_77563411 0.42 ENSDART00000186841
AL935186.8

chr21_-_27362938 0.42 ENSDART00000131297
rin1a
Ras and Rab interactor 1a
chr24_-_38374744 0.42 ENSDART00000007208
lrrc4bb
leucine rich repeat containing 4Bb
chr18_+_24919614 0.37 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr12_-_8958353 0.36 ENSDART00000041728
cyp26a1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr2_-_42415902 0.36 ENSDART00000142489
slco5a1b
solute carrier organic anion transporter family member 5A1b
chr22_-_17953529 0.35 ENSDART00000135716
ncanb
neurocan b
chr21_-_34926619 0.34 ENSDART00000065337
ENSDART00000192740
kif20a
kinesin family member 20A
chr7_+_529522 0.34 ENSDART00000190811
nrxn2b
neurexin 2b
chr10_-_43964028 0.32 ENSDART00000009134
ENSDART00000133450
sept5b
septin 5b
chr13_+_16521898 0.32 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr12_+_35119762 0.32 ENSDART00000085774
si:ch73-127m5.1
si:ch73-127m5.1
chr23_-_1017605 0.30 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr21_+_21279159 0.30 ENSDART00000148346
itpkca
inositol-trisphosphate 3-kinase Ca
chr16_-_20435475 0.30 ENSDART00000139776
chn2
chimerin 2
chr6_+_38381957 0.26 ENSDART00000087300
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr23_-_1017428 0.26 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr18_+_18104235 0.25 ENSDART00000145342
cbln1
cerebellin 1 precursor
chr14_+_10450216 0.25 ENSDART00000134814
cysltr1
cysteinyl leukotriene receptor 1
chr8_+_29963024 0.24 ENSDART00000149372
ptch1
patched 1
chr20_-_54014373 0.24 ENSDART00000152934
si:dkey-241l7.6
si:dkey-241l7.6
chr12_+_24562667 0.24 ENSDART00000056256
nrxn1a
neurexin 1a
chr25_+_22017182 0.23 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr25_+_8063455 0.23 ENSDART00000073919
kcnc1b
potassium voltage-gated channel, Shaw-related subfamily, member 1b
chr11_-_33857911 0.23 ENSDART00000165370
nxph2b
neurexophilin 2b
chr6_+_102506 0.22 ENSDART00000172678
ldlrb
low density lipoprotein receptor b
chr17_-_26868169 0.22 ENSDART00000157204
si:dkey-221l4.10
si:dkey-221l4.10
chr11_-_35975026 0.21 ENSDART00000186219
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr23_-_27701361 0.21 ENSDART00000186688
ENSDART00000183985
dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr4_+_58667348 0.21 ENSDART00000186596
ENSDART00000180673
CR388148.2

chr1_+_32528097 0.21 ENSDART00000128317
nlgn4a
neuroligin 4a
chr17_-_19019635 0.20 ENSDART00000126666
flrt2
fibronectin leucine rich transmembrane protein 2
chr2_-_34555945 0.20 ENSDART00000056671
brinp2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr25_+_31264155 0.19 ENSDART00000012256
tnni2a.3
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr5_+_45921234 0.19 ENSDART00000134355
ankdd1b
ankyrin repeat and death domain containing 1B
chr17_-_26867725 0.18 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr24_+_37723362 0.18 ENSDART00000136836
rab11fip3
RAB11 family interacting protein 3 (class II)
chr25_+_21180695 0.18 ENSDART00000012923
erc1a
ELKS/RAB6-interacting/CAST family member 1a
chr22_+_508290 0.18 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr2_-_9544161 0.18 ENSDART00000124425
slc25a24l
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, like
chr14_+_11103718 0.17 ENSDART00000161311
nexmifb
neurite extension and migration factor b
chr7_+_1442059 0.17 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr3_+_16455749 0.16 ENSDART00000090767
kcnj12b
potassium inwardly-rectifying channel, subfamily J, member 12b
chr25_+_16945348 0.15 ENSDART00000016591
fgf6a
fibroblast growth factor 6a
chr5_-_15948833 0.14 ENSDART00000051649
ENSDART00000124467
xbp1
X-box binding protein 1
chr1_-_55248496 0.13 ENSDART00000098615
nanos3
nanos homolog 3
chr13_+_36585399 0.13 ENSDART00000030211
gmfb
glia maturation factor, beta
chr23_+_39461989 0.13 ENSDART00000184761
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr2_+_39108339 0.11 ENSDART00000085675
clstn2
calsyntenin 2
chr21_+_21205667 0.11 ENSDART00000058311
rictorb
RPTOR independent companion of MTOR, complex 2b
chr10_-_27197044 0.11 ENSDART00000137928
auts2a
autism susceptibility candidate 2a
chr12_-_21834611 0.11 ENSDART00000179553
thrab
thyroid hormone receptor alpha b
chr25_-_32363341 0.11 ENSDART00000153892
ENSDART00000114385
cep152
centrosomal protein 152
chr25_+_6471401 0.10 ENSDART00000132927
snx33
sorting nexin 33
chr6_+_7322587 0.10 ENSDART00000065500
abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr19_+_41080240 0.10 ENSDART00000087295
ppp1r9a
protein phosphatase 1, regulatory subunit 9A
chr12_+_5708400 0.10 ENSDART00000017191
dlx3b
distal-less homeobox 3b
chr5_+_7393346 0.09 ENSDART00000164238
si:ch73-72b7.1
si:ch73-72b7.1
chr25_-_26753196 0.09 ENSDART00000155698
usp3
ubiquitin specific peptidase 3
chr20_-_3160687 0.08 ENSDART00000131697
si:ch73-212j7.3
si:ch73-212j7.3
chr16_-_21620947 0.08 ENSDART00000115011
ENSDART00000183125
ENSDART00000188856
ENSDART00000189460
ddr1
discoidin domain receptor tyrosine kinase 1
chr22_-_9906790 0.08 ENSDART00000105936
si:dkey-253d23.8
si:dkey-253d23.8
chr12_-_27242498 0.08 ENSDART00000152609
ENSDART00000152170
si:dkey-11c5.11
si:dkey-11c5.11
chr12_+_30360184 0.07 ENSDART00000190718
si:ch211-225b10.3
si:ch211-225b10.3
chr25_+_23489979 0.07 ENSDART00000158200
CU024870.1

chr18_+_40364732 0.07 ENSDART00000123661
ENSDART00000130847
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr15_-_45246911 0.07 ENSDART00000189557
ENSDART00000185291
CABZ01072607.1

chr6_-_19035749 0.07 ENSDART00000187714
sept9b
septin 9b
chr16_+_54209504 0.06 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr14_-_51039702 0.05 ENSDART00000178932
cltb
clathrin, light chain B
chr13_-_35497586 0.05 ENSDART00000148402
srd5a2b
steroid-5-alpha-reductase, alpha polypeptide 2b
chr12_-_32013125 0.05 ENSDART00000153355
grin2cb
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr7_-_8881514 0.05 ENSDART00000081620
vax2
ventral anterior homeobox 2
chr7_-_7420301 0.05 ENSDART00000102620
six7
SIX homeobox 7
chr10_-_5135788 0.04 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr3_-_43646733 0.04 ENSDART00000180959
axin1
axin 1
chr20_-_47188966 0.04 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr1_+_58990121 0.04 ENSDART00000171654
CABZ01083166.1

chr17_-_27972307 0.03 ENSDART00000062130
ptafr
platelet-activating factor receptor
chr4_-_63980140 0.03 ENSDART00000160818
znf1091
zinc finger protein 1091
chr17_-_29771639 0.03 ENSDART00000086201
ush2a
Usher syndrome 2A (autosomal recessive, mild)
chr12_+_30360579 0.03 ENSDART00000152900
si:ch211-225b10.3
si:ch211-225b10.3
chr10_+_6383270 0.03 ENSDART00000170548
zgc:114200
zgc:114200
chr1_+_18863060 0.03 ENSDART00000139241
rnf38
ring finger protein 38
chr6_+_9867426 0.02 ENSDART00000151749
MPP4 (1 of many)
si:ch211-222n4.6
chr6_-_59942335 0.02 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr20_+_51199666 0.02 ENSDART00000169321
hsp90ab1
heat shock protein 90, alpha (cytosolic), class B member 1
chr25_-_20870900 0.02 ENSDART00000171288
magi2b
membrane associated guanylate kinase, WW and PDZ domain containing 2b
chr23_+_25868637 0.01 ENSDART00000103934
ttpal
tocopherol (alpha) transfer protein-like
chr21_+_39292266 0.01 ENSDART00000144116
si:ch211-274p24.2
si:ch211-274p24.2
chr5_-_7513082 0.01 ENSDART00000158913
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr7_+_1812480 0.01 ENSDART00000173278
si:ch73-126o18.1
si:ch73-126o18.1
chr9_+_33334501 0.00 ENSDART00000006867
ddx3a
DEAD (Asp-Glu-Ala-Asp) box helicase 3a
chr9_+_44721808 0.00 ENSDART00000190578
nckap1
NCK-associated protein 1
chr15_-_18213515 0.00 ENSDART00000101635
btr21
bloodthirsty-related gene family, member 21

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0046959 nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.4 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.1 GO:0048785 hatching gland development(GO:0048785)
0.0 0.2 GO:2000048 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.4 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.2 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.4 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.0 GO:0030910 olfactory placode formation(GO:0030910)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.1 GO:0038203 TORC2 signaling(GO:0038203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.4 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.1 0.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling