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PRJNA207719: Tissue specific transcriptome profiling
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Results for tfdp1a+tfdp1b
Z-value: 3.98
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Transcription factors associated with tfdp1a+tfdp1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tfdp1a | dr11_v1_chr9_+_34950942_34950942 | 0.72 | 1.7e-01 | Click! |
| tfdp1b | dr11_v1_chr1_+_227241_227241 | 0.36 | 5.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_27966526 Show fit | 3.26 |
ENSDART00000141896
|
ubiquitin-conjugating enzyme E2Q family-like 1 |
|
| chr21_-_41305748 Show fit | 2.82 |
ENSDART00000170457
|
neuronal vesicle trafficking associated 2 |
|
| chr19_-_27966780 Show fit | 2.81 |
ENSDART00000110016
|
ubiquitin-conjugating enzyme E2Q family-like 1 |
|
| chr4_+_5741733 Show fit | 2.79 |
ENSDART00000110243
|
POU class 3 homeobox 2a |
|
| chr18_-_5692292 Show fit | 2.52 |
ENSDART00000121503
|
complexin 3b |
|
| chr4_-_5764255 Show fit | 2.46 |
ENSDART00000113864
|
failed axon connections homolog a |
|
| chr21_-_28340977 Show fit | 2.26 |
ENSDART00000141629
|
neurexin 2a |
|
| chr3_-_59472422 Show fit | 2.25 |
ENSDART00000100327
|
neuronal pentraxin 1 like |
|
| chr17_-_17447899 Show fit | 2.13 |
ENSDART00000156928
ENSDART00000109034 |
neurexin 3a |
|
| chr18_+_18104235 Show fit | 2.09 |
ENSDART00000145342
|
cerebellin 1 precursor |
Network of associatons between targets according to the STRING database.
First level regulatory network of tfdp1a+tfdp1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 5.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 5.7 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.2 | 5.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 4.4 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.1 | 4.2 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.2 | 3.9 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 0.1 | 3.5 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.1 | 3.3 | GO:0046328 | regulation of JNK cascade(GO:0046328) |
| 0.2 | 3.1 | GO:0035493 | SNARE complex assembly(GO:0035493) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 11.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.3 | 11.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 8.9 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 7.8 | GO:0005768 | endosome(GO:0005768) |
| 0.2 | 4.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 4.2 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 3.8 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 3.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 3.3 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 6.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.4 | 5.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 5.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.7 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 4.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.7 | 4.4 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.0 | 4.2 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 4.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.6 | 3.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 4.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.1 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 1.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 2.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 2.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 2.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 2.0 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 1.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.6 | 1.7 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |