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PRJNA207719: Tissue specific transcriptome profiling

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Results for thrb

Z-value: 0.76

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Transcription factors associated with thrb

Gene Symbol Gene ID Gene Info
thrb
ENSDARG00000021163 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
thrbdr11_v1_chr19_-_17526735_17526735-0.553.4e-01Click!

Activity profile of thrb motif

Sorted Z-values of thrb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_23645810 1.08 ENSDART00000168845
ckmb
creatine kinase, muscle b
chr22_-_2886937 0.80 ENSDART00000063533
aqp12
aquaporin 12
chr5_+_28857969 0.49 ENSDART00000149850
si:ch211-186e20.2
si:ch211-186e20.2
chr5_+_28797771 0.46 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
si:ch211-186e20.7
chr6_+_60112200 0.44 ENSDART00000008243
prelid3b
PRELI domain containing 3
chr13_-_22862133 0.39 ENSDART00000138563
pbld2
phenazine biosynthesis-like protein domain containing 2
chr15_-_34878388 0.36 ENSDART00000154094
mgat1a
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a
chr19_-_32804535 0.32 ENSDART00000175613
ENSDART00000052098
nt5c1aa
5'-nucleotidase, cytosolic IAa
chr2_+_10766744 0.23 ENSDART00000015379
gfi1aa
growth factor independent 1A transcription repressor a
chr7_-_8156169 0.21 ENSDART00000182960
ENSDART00000190184
ENSDART00000190885
ENSDART00000189867
ENSDART00000160836
si:cabz01030277.1
si:ch211-163c2.3
si:cabz01030277.1
si:ch211-163c2.3
chr5_+_38673168 0.21 ENSDART00000135267
si:dkey-58f10.12
si:dkey-58f10.12
chr4_-_64141714 0.16 ENSDART00000128628
BX914205.3

chr7_-_8014186 0.15 ENSDART00000190012
si:cabz01030277.1
si:cabz01030277.1
chr15_+_5088210 0.15 ENSDART00000183423
mxf
myxovirus (influenza virus) resistance F
chr20_-_35750810 0.15 ENSDART00000153072
adgrf8
adhesion G protein-coupled receptor F8
chr22_-_6219092 0.15 ENSDART00000150040
si:ch211-274k16.2
si:ch211-274k16.2
chr4_-_64142389 0.13 ENSDART00000172126
BX914205.3

chr13_+_33462232 0.12 ENSDART00000177841
zgc:136302
zgc:136302
chr6_-_51556308 0.04 ENSDART00000149033
rbl1
retinoblastoma-like 1 (p107)
chr2_+_19163965 0.04 ENSDART00000166073
elovl1a
ELOVL fatty acid elongase 1a
chr4_+_16768961 0.03 ENSDART00000143926
BX649500.1

chr19_+_29854223 0.02 ENSDART00000109729
ENSDART00000157419
si:ch73-130a3.4
si:ch73-130a3.4
chr15_-_34408777 0.02 ENSDART00000139934
agmo
alkylglycerol monooxygenase
chr3_+_34846201 0.01 ENSDART00000055263
itga3a
integrin, alpha 3a

Network of associatons between targets according to the STRING database.

First level regulatory network of thrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.8 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 1.1 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.4 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)