ISMARA results: tp53

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PRJNA207719: Tissue specific transcriptome profiling

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Results for tp53

Z-value: 2.78

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Transcription factors associated with tp53

Gene Symbol	Gene ID	Gene Info
tp53 NCBI UniProt	ENSDARG00000035559	tumor protein p53
tp53 NCBI UniProt	ENSDARG00000115148	tumor protein p53

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tp53	dr11_v1_chr5_+_24087035_24087035	0.88	4.9e-02	Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_-_31428763 Show fit	3.53	ENSDART00000053545	zgc:153284 NCBI UniProt Show fit	zgc:153284
chr3_-_28828242 Show fit	2.91	ENSDART00000151445	si:ch211-76l23.4 NCBI UniProt Show fit	si:ch211-76l23.4
chr3_-_28828569 Show fit	2.30	ENSDART00000167679	si:ch211-76l23.4 NCBI UniProt Show fit	si:ch211-76l23.4
chr7_-_2430286 Show fit	2.29	ENSDART00000129312	zgc:66473 NCBI UniProt Show fit	zgc:66473
chr13_+_24755049 Show fit	2.28	ENSDART00000134102	col17a1b NCBI UniProt Show fit	collagen, type XVII, alpha 1b
chr5_+_29831235 Show fit	2.22	ENSDART00000109660	f11r.1 NCBI UniProt Show fit	F11 receptor, tandem duplicate 1
chr12_+_22576404 Show fit	2.22	ENSDART00000172053	capgb NCBI UniProt Show fit	capping protein (actin filament), gelsolin-like b
chr22_-_6404807 Show fit	2.21	ENSDART00000149399 ENSDART00000063420	si:rp71-1i20.2 NCBI UniProt Show fit	si:rp71-1i20.2
chr5_+_27404946 Show fit	2.19	ENSDART00000121886 ENSDART00000005025	hdr NCBI UniProt Show fit	hematopoietic death receptor
chr5_+_24089334 Show fit	2.09	ENSDART00000183748	tp53 NCBI UniProt Show fit	tumor protein p53

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:0033627	cell adhesion mediated by integrin(GO:0033627)
0.5	2.2	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.2	2.2	GO:0050892	intestinal absorption(GO:0050892)
0.1	2.2	GO:2000601	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	2.2	GO:0051014	actin filament severing(GO:0051014)
0.0	2.2	GO:0006414	translational elongation(GO:0006414)
0.7	2.1	GO:0032197	regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.1	2.1	GO:0003094	glomerular filtration(GO:0003094)
0.5	1.9	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2	1.8	GO:2000273	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	GO:0009986	cell surface(GO:0009986)
0.0	5.5	GO:0000785	chromatin(GO:0000785)
0.0	4.3	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	3.8	GO:0030027	lamellipodium(GO:0030027)
0.0	2.9	GO:0005884	actin filament(GO:0005884)
0.0	2.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.8	2.4	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.0	1.9	GO:0016342	catenin complex(GO:0016342)
0.0	1.7	GO:0005902	microvillus(GO:0005902)
0.0	1.6	GO:0030864	cortical actin cytoskeleton(GO:0030864)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	3.2	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	2.8	GO:0000146	microfilament motor activity(GO:0000146)
0.0	2.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	2.4	GO:0005178	integrin binding(GO:0005178)
0.0	2.3	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	2.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	2.1	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.6	1.9	GO:1901612	cardiolipin binding(GO:1901612)

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	2.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	2.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	2.0	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.5	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	1.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.3	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	1.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.0	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	2.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	1.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.3	REACTOME KINESINS	Genes involved in Kinesins
0.1	1.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	1.0	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.6	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.4	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)

Showing 1 to 10 of 15 entries

Results for tp53

Z-value: 2.78

Motif logo

Transcription factors associated with tp53

Activity-expression correlation:

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: