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PRJNA207719: Tissue specific transcriptome profiling

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Results for tp63

Z-value: 0.60

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Transcription factors associated with tp63

Gene Symbol Gene ID Gene Info
tp63
ENSDARG00000044356 tumor protein p63
tp63
ENSDARG00000113627 tumor protein p63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp63dr11_v1_chr6_+_28877306_28877441-0.286.4e-01Click!

Activity profile of tp63 motif

Sorted Z-values of tp63 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_14671098 0.65 ENSDART00000037371
ppp1r13ba
protein phosphatase 1, regulatory subunit 13Ba
chr14_+_24241241 0.50 ENSDART00000022377
nkx2.5
NK2 homeobox 5
chr19_-_31035155 0.39 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr19_-_31035325 0.33 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr12_+_45200744 0.32 ENSDART00000098932
wbp2
WW domain binding protein 2
chr23_+_44307996 0.29 ENSDART00000042430
dlg4b
discs, large homolog 4b (Drosophila)
chr9_-_15424639 0.28 ENSDART00000124346
fn1a
fibronectin 1a
chr7_-_50914526 0.27 ENSDART00000160398
ankrd46b
ankyrin repeat domain 46b
chr7_+_26138240 0.26 ENSDART00000193750
ENSDART00000184942
nat16
N-acetyltransferase 16
chr2_-_32501501 0.26 ENSDART00000181309
faim2a
Fas apoptotic inhibitory molecule 2a
chr17_+_53250802 0.24 ENSDART00000143819
VASH1
vasohibin 1
chr15_-_29387446 0.24 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr5_-_1999417 0.23 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
si:ch211-160e1.5
chr16_-_17207754 0.21 ENSDART00000063804
wu:fj39g12
wu:fj39g12
chr25_+_31912153 0.19 ENSDART00000153968
apba2a
amyloid beta (A4) precursor protein-binding, family A, member 2a
chr14_-_9522364 0.18 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr14_+_22132896 0.18 ENSDART00000138274
ccng1
cyclin G1
chr5_+_33301005 0.17 ENSDART00000006021
usp20
ubiquitin specific peptidase 20
chr16_+_41717313 0.16 ENSDART00000015170
ENSDART00000075937
mtdhb
metadherin b
chr10_+_39091353 0.16 ENSDART00000125986
si:ch73-1a9.4
si:ch73-1a9.4
chr7_+_22702437 0.16 ENSDART00000182054
si:dkey-165a24.9
si:dkey-165a24.9
chr1_+_36651059 0.16 ENSDART00000187475
ednraa
endothelin receptor type Aa
chr17_-_7861219 0.15 ENSDART00000148604
syne1b
spectrin repeat containing, nuclear envelope 1b
chr21_-_45613564 0.14 ENSDART00000160324
LO018363.1

chr10_+_5135842 0.14 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr10_-_6867282 0.14 ENSDART00000144001
ENSDART00000109744
ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr20_-_1314537 0.13 ENSDART00000144288
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr3_-_28120092 0.13 ENSDART00000151143
rbfox1
RNA binding fox-1 homolog 1
chr17_-_43466317 0.13 ENSDART00000155313
hspa4l
heat shock protein 4 like
chr4_+_23127284 0.13 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr21_+_40498628 0.13 ENSDART00000163454
coro6
coronin 6
chr12_+_26670778 0.12 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr7_+_69653981 0.11 ENSDART00000090165
frem1a
Fras1 related extracellular matrix 1a
chr1_+_36436936 0.11 ENSDART00000124112
pou4f2
POU class 4 homeobox 2
chr17_+_30450163 0.10 ENSDART00000104257
lpin1
lipin 1
chr5_+_29851433 0.09 ENSDART00000143434
ubash3ba
ubiquitin associated and SH3 domain containing Ba
chr20_-_27325258 0.09 ENSDART00000152917
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr20_-_1314355 0.09 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr18_-_17399291 0.08 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zfpm1
zinc finger protein, FOG family member 1
chr14_-_30983011 0.08 ENSDART00000014095
rap2c
RAP2C, member of RAS oncogene family
chr2_+_47489679 0.07 ENSDART00000074968
acsl3b
acyl-CoA synthetase long chain family member 3b
chr19_+_41173386 0.06 ENSDART00000142773
asb4
ankyrin repeat and SOCS box containing 4
chr7_+_22702225 0.06 ENSDART00000173672
si:dkey-165a24.9
si:dkey-165a24.9
chr17_-_22324727 0.06 ENSDART00000160341
CU104709.1

chr20_-_25436389 0.05 ENSDART00000153266
itsn2a
intersectin 2a
chr23_-_17470146 0.05 ENSDART00000002398
trim101
tripartite motif containing 101
chr9_-_3958533 0.05 ENSDART00000129091
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr4_+_23127104 0.05 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr5_+_38913621 0.05 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr25_+_33033633 0.04 ENSDART00000192336
tln2b
talin 2b
chr21_+_44581654 0.04 ENSDART00000187201
ENSDART00000180360
ENSDART00000191543
ENSDART00000180039
ENSDART00000186308
TMEM164
transmembrane protein 164
chr16_-_41717063 0.04 ENSDART00000084610
cep85
centrosomal protein 85
chr12_-_4651988 0.04 ENSDART00000182836
si:ch211-255p10.4
si:ch211-255p10.4
chr2_-_37837472 0.04 ENSDART00000165347
mettl17
methyltransferase like 17
chr15_-_10455438 0.03 ENSDART00000158958
ENSDART00000192971
ENSDART00000162133
ENSDART00000185071
ENSDART00000192444
ENSDART00000165668
ENSDART00000175825
tenm4
teneurin transmembrane protein 4
chr17_+_43623598 0.03 ENSDART00000154138
znf365
zinc finger protein 365
chr4_+_23126558 0.03 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr8_-_38506339 0.03 ENSDART00000054558
ENSDART00000141623
foxb2
forkhead box B2
chr4_+_25693463 0.03 ENSDART00000132864
acot18
acyl-CoA thioesterase 18
chr13_-_12581388 0.03 ENSDART00000079655
enpep
glutamyl aminopeptidase
chr2_+_37837249 0.03 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr23_+_39346930 0.02 ENSDART00000102843
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr7_-_8324927 0.02 ENSDART00000102535
f13a1b
coagulation factor XIII, A1 polypeptide b
chr18_+_44631789 0.02 ENSDART00000144271
bicra
BRD4 interacting chromatin remodeling complex associated protein
chr18_-_33080454 0.01 ENSDART00000191907
v2ra18
vomeronasal 2 receptor, a18
chr13_-_2060713 0.01 ENSDART00000038434
hcrtr2
hypocretin (orexin) receptor 2
chr8_+_2487883 0.01 ENSDART00000101841
dynll1
dynein, light chain, LC8-type 1
chr22_+_2844865 0.01 ENSDART00000139123
si:dkey-20i20.4
si:dkey-20i20.4
chr21_-_27251112 0.01 ENSDART00000137667
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr9_+_41103127 0.01 ENSDART00000000250
slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
chr23_-_21748805 0.01 ENSDART00000148128
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr8_-_4694458 0.01 ENSDART00000019828
zgc:63587
zgc:63587
chr10_+_25355308 0.01 ENSDART00000100415
map3k7cl
map3k7 C-terminal like
chr24_+_35564668 0.00 ENSDART00000122734
cebpd
CCAAT/enhancer binding protein (C/EBP), delta

Network of associatons between targets according to the STRING database.

First level regulatory network of tp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 0.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.3 GO:0072578 neurotransmitter-gated ion channel clustering(GO:0072578)
0.0 0.3 GO:0006953 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319) acute-phase response(GO:0006953) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.2 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.0 0.2 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.0 0.1 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.0 GO:0030882 lipid antigen binding(GO:0030882)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol