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PRJNA207719: Tissue specific transcriptome profiling

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Results for vax2

Z-value: 0.51

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Transcription factors associated with vax2

Gene Symbol Gene ID Gene Info
vax2
ENSDARG00000058702 ventral anterior homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
vax2dr11_v1_chr7_-_8881514_88815140.335.9e-01Click!

Activity profile of vax2 motif

Sorted Z-values of vax2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_21129752 0.33 ENSDART00000169764
syt1a
synaptotagmin Ia
chr8_+_16025554 0.30 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr2_+_50608099 0.29 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr21_+_31150438 0.29 ENSDART00000065366
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_46941245 0.28 ENSDART00000037875
igfn1.1
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 1
chr6_+_27151940 0.26 ENSDART00000088364
kif1aa
kinesin family member 1Aa
chr15_-_33925851 0.25 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr21_+_31150773 0.25 ENSDART00000126205
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr3_-_26017831 0.24 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr9_-_44295071 0.23 ENSDART00000011837
neurod1
neuronal differentiation 1
chr20_-_28800999 0.23 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr12_+_47698356 0.22 ENSDART00000112010
lzts2b
leucine zipper, putative tumor suppressor 2b
chr5_+_37903790 0.21 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr8_+_49778486 0.21 ENSDART00000131732
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr21_+_28958471 0.19 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr14_-_4556896 0.19 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr10_+_21867307 0.19 ENSDART00000126629
cbln17
cerebellin 17
chr20_-_40754794 0.18 ENSDART00000187251
cx32.3
connexin 32.3
chr10_+_42423318 0.17 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr2_-_38000276 0.17 ENSDART00000034790
pcp4l1
Purkinje cell protein 4 like 1
chr2_+_6253246 0.17 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr11_-_2131280 0.17 ENSDART00000008409
calcoco1b
calcium binding and coiled-coil domain 1b
chr4_-_17055950 0.16 ENSDART00000162945
sox5
SRY (sex determining region Y)-box 5
chr13_-_29420885 0.15 ENSDART00000024225
chata
choline O-acetyltransferase a
chr9_-_43538328 0.14 ENSDART00000140526
znf385b
zinc finger protein 385B
chr8_-_12264486 0.14 ENSDART00000091612
ENSDART00000135812
dab2ipa
DAB2 interacting protein a
chr19_+_5480327 0.14 ENSDART00000148794
jupb
junction plakoglobin b
chr17_-_200316 0.14 ENSDART00000190561
CABZ01083778.1

chr11_-_42554290 0.14 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr14_-_49063157 0.13 ENSDART00000021260
sept8b
septin 8b
chr14_-_30587814 0.13 ENSDART00000144912
ENSDART00000149714
tmem265
transmembrane protein 265
chr6_+_7421898 0.12 ENSDART00000043946
ccdc65
coiled-coil domain containing 65
chr12_+_3078221 0.12 ENSDART00000148835
ENSDART00000149427
sgca
sarcoglycan, alpha
chr4_-_1801519 0.12 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr18_+_17827149 0.11 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr17_+_30369107 0.11 ENSDART00000182286
ENSDART00000139091
greb1
growth regulation by estrogen in breast cancer 1
chr16_-_32837806 0.10 ENSDART00000003997
MCHR2
si:dkey-165n16.5
chr14_-_858985 0.10 ENSDART00000148687
ENSDART00000149375
slc34a1a
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr14_+_45406299 0.10 ENSDART00000173142
ENSDART00000112377
map1lc3cl
microtubule-associated protein 1 light chain 3 gamma, like
chr3_-_21280373 0.10 ENSDART00000003939
syngr1a
synaptogyrin 1a
chr2_+_53204750 0.10 ENSDART00000163644
zgc:165603
zgc:165603
chr17_+_3379673 0.10 ENSDART00000176354
sntg2
syntrophin, gamma 2
chr16_-_42056137 0.10 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr15_+_36188171 0.10 ENSDART00000156598
masp1
mannan-binding lectin serine peptidase 1
chr12_-_33357655 0.10 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr15_-_11683529 0.09 ENSDART00000161445
fkrp
fukutin related protein
chr3_+_17537352 0.09 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr23_-_15216654 0.09 ENSDART00000131649
sulf2b
sulfatase 2b
chr23_+_238893 0.08 ENSDART00000138198
PDZD4
si:ch73-162j3.4
chr11_+_38280454 0.08 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr20_-_9278252 0.08 ENSDART00000136079
syt14b
synaptotagmin XIVb
chr21_+_32820175 0.08 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr22_-_8725768 0.08 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
si:ch73-27e22.1
si:ch73-27e22.8
chr21_+_30355767 0.08 ENSDART00000189948
CR749164.1

chr7_-_41746427 0.07 ENSDART00000174232
arl8
ADP-ribosylation factor-like 8
chr6_-_7726849 0.07 ENSDART00000151511
slc25a38b
solute carrier family 25, member 38b
chr11_-_40728380 0.07 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr4_+_9400012 0.07 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr18_+_34225520 0.07 ENSDART00000126115
v2rl1
vomeronasal 2 receptor, l1
chr7_+_54642005 0.07 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr16_+_13818500 0.07 ENSDART00000135245
flcn
folliculin
chr15_-_5815006 0.06 ENSDART00000102459
rbp2a
retinol binding protein 2a, cellular
chr1_-_33351780 0.06 ENSDART00000178996
gyg2
glycogenin 2
chr17_+_15983557 0.06 ENSDART00000190806
clmn
calmin
chr5_+_56023186 0.06 ENSDART00000156230
fzd9a
frizzled class receptor 9a
chr15_-_22074315 0.06 ENSDART00000149830
drd2a
dopamine receptor D2a
chr17_-_49978986 0.06 ENSDART00000154728
col12a1a
collagen, type XII, alpha 1a
chr25_-_7705487 0.06 ENSDART00000128099
prdm11
PR domain containing 11
chr1_-_15797663 0.06 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr13_+_38817871 0.06 ENSDART00000187708
col19a1
collagen, type XIX, alpha 1
chr3_-_20040636 0.05 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr23_+_30827959 0.05 ENSDART00000033429
npbwr2a
neuropeptides B/W receptor 2a
chr7_+_42461850 0.05 ENSDART00000190350
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr6_-_46861676 0.05 ENSDART00000188712
ENSDART00000190148
igfn1.3
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr20_+_28861629 0.05 ENSDART00000187274
ENSDART00000047826
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr11_-_6452444 0.05 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
larp6b
La ribonucleoprotein domain family, member 6b
chr23_+_28809002 0.05 ENSDART00000134121
ENSDART00000183661
pex14
peroxisomal biogenesis factor 14
chr14_-_8724290 0.05 ENSDART00000161171
pimr56
Pim proto-oncogene, serine/threonine kinase, related 56
chr6_-_12275836 0.04 ENSDART00000189980
pkp4
plakophilin 4
chr5_-_51619742 0.04 ENSDART00000188537
otpb
orthopedia homeobox b
chr22_+_18477934 0.04 ENSDART00000132684
cilp2
cartilage intermediate layer protein 2
chr10_-_105100 0.04 ENSDART00000145716
ttc3
tetratricopeptide repeat domain 3
chr14_+_29941445 0.04 ENSDART00000181761
fam149a
family with sequence similarity 149 member A
chr8_-_53044300 0.04 ENSDART00000191653
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr23_+_37086159 0.04 ENSDART00000074407
cptp
ceramide-1-phosphate transfer protein
chr7_-_12464412 0.04 ENSDART00000178723
adamtsl3
ADAMTS-like 3
chr14_+_5385855 0.04 ENSDART00000031508
lbx2
ladybird homeobox 2
chrM_+_12897 0.04 ENSDART00000093622
mt-nd5
NADH dehydrogenase 5, mitochondrial
chr16_+_23984179 0.03 ENSDART00000175879
apoc2
apolipoprotein C-II
chr22_-_209741 0.03 ENSDART00000171954
ora1
olfactory receptor class A related 1
chr15_+_23799461 0.03 ENSDART00000154885
si:ch211-167j9.4
si:ch211-167j9.4
chr3_+_54744069 0.03 ENSDART00000134958
ENSDART00000114443
si:ch211-74m13.3
si:ch211-74m13.3
chr8_+_22516728 0.03 ENSDART00000146013
si:ch211-261n11.3
si:ch211-261n11.3
chr6_+_24420523 0.03 ENSDART00000185461
tgfbr3
transforming growth factor, beta receptor III
chr9_-_32177117 0.03 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr10_+_38560032 0.03 ENSDART00000177197
LO018336.1

chr1_+_49668423 0.03 ENSDART00000150880
tsga10
testis specific, 10
chr1_-_50859053 0.03 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr5_-_68093169 0.03 ENSDART00000051849
slc25a11
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
chr13_-_37229245 0.03 ENSDART00000140923
si:dkeyp-77c8.5
si:dkeyp-77c8.5
chr15_+_34988148 0.03 ENSDART00000076269
ccdc105
coiled-coil domain containing 105
chr4_-_48957129 0.03 ENSDART00000150426
znf1064
zinc finger protein 1064
chr25_+_10913725 0.03 ENSDART00000153472
mhc1lja
major histocompatibility complex class I LJA
chr23_-_33679579 0.02 ENSDART00000188674
tfcp2
transcription factor CP2
chr23_-_2901167 0.02 ENSDART00000165955
ENSDART00000190616
zhx3
zinc fingers and homeoboxes 3
chr24_+_12894282 0.02 ENSDART00000061301
si:dkeyp-28d2.4
si:dkeyp-28d2.4
chr14_-_34771371 0.02 ENSDART00000160598
ENSDART00000150413
ENSDART00000168910
ablim3
actin binding LIM protein family, member 3
chr23_-_25779995 0.02 ENSDART00000110670
si:dkey-21c19.3
si:dkey-21c19.3
chr16_+_13818743 0.02 ENSDART00000090191
flcn
folliculin
chr9_+_38372216 0.02 ENSDART00000141895
plcd4b
phospholipase C, delta 4b
chr20_-_9095105 0.02 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr10_+_40284003 0.02 ENSDART00000062795
ENSDART00000193825
ENSDART00000113582
git2b
G protein-coupled receptor kinase interacting ArfGAP 2b
chr13_-_8692860 0.02 ENSDART00000058107
mcfd2
multiple coagulation factor deficiency 2
chr25_-_13490744 0.02 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr10_+_13000669 0.02 ENSDART00000158919
ENSDART00000172625
lpar1
lysophosphatidic acid receptor 1
chr24_+_26134209 0.02 ENSDART00000038824
tmtopsb
teleost multiple tissue opsin b
chr21_+_42930558 0.02 ENSDART00000135234
stk32a
serine/threonine kinase 32A
chr4_-_58978527 0.02 ENSDART00000150408
si:ch211-64i20.5_2
si:ch211-64i20.5_2
chr20_-_7133546 0.02 ENSDART00000160910
si:ch211-121a2.4
si:ch211-121a2.4
chr3_-_26787430 0.02 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr7_+_9873750 0.02 ENSDART00000173348
ENSDART00000172813
lins1
lines homolog 1
chr16_+_31804590 0.02 ENSDART00000167321
wnt4b
wingless-type MMTV integration site family, member 4b
chr8_+_45186989 0.02 ENSDART00000143861
si:ch211-220m6.4
si:ch211-220m6.4
chr2_-_24317240 0.02 ENSDART00000078975
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr4_-_30422325 0.01 ENSDART00000158444
znf1114
zinc finger protein 1114
chr7_-_9873652 0.01 ENSDART00000006343
asb7
ankyrin repeat and SOCS box containing 7
chr8_+_23521974 0.01 ENSDART00000188130
ENSDART00000129378
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr2_+_57848844 0.01 ENSDART00000037279
plekhj1
pleckstrin homology domain containing, family J member 1
chr20_+_28861435 0.01 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr11_-_21528056 0.01 ENSDART00000181626
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr8_+_25034544 0.01 ENSDART00000123300
ngrn
neugrin, neurite outgrowth associated
chr5_-_66397688 0.01 ENSDART00000161483
hip1rb
huntingtin interacting protein 1 related b
chr2_+_10007113 0.01 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr1_-_55248496 0.01 ENSDART00000098615
nanos3
nanos homolog 3
chr15_+_6774994 0.01 ENSDART00000170011
si:ch1073-228b5.2
si:ch1073-228b5.2
chr9_-_11676491 0.01 ENSDART00000022358
zc3h15
zinc finger CCCH-type containing 15
chr13_-_8692432 0.01 ENSDART00000058106
mcfd2
multiple coagulation factor deficiency 2
chr24_-_5786759 0.01 ENSDART00000152069
chst2b
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2b
chr7_-_31922432 0.01 ENSDART00000188398
lin7c
lin-7 homolog C (C. elegans)
chr18_+_28106139 0.01 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr11_-_2838699 0.01 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr10_-_5581487 0.01 ENSDART00000141943
syk
spleen tyrosine kinase
chr2_-_9818640 0.01 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr15_-_12011390 0.01 ENSDART00000187403
si:dkey-202l22.6
si:dkey-202l22.6
chr11_-_3533356 0.00 ENSDART00000161972
ddx19
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)
chr4_+_44954486 0.00 ENSDART00000150875
si:dkeyp-100h4.8
si:dkeyp-100h4.8
chr13_+_40501455 0.00 ENSDART00000114985
hpse2
heparanase 2
chr8_+_24296639 0.00 ENSDART00000172002
ZNF335
si:ch211-269m15.3
chr22_+_23359369 0.00 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr12_+_20587179 0.00 ENSDART00000170127
arsg
arylsulfatase G

Network of associatons between targets according to the STRING database.

First level regulatory network of vax2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0007585 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.1 0.2 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.0 0.1 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0042755 eating behavior(GO:0042755)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.3 GO:2000344 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0050936 xanthophore differentiation(GO:0050936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.2 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.2 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.0 GO:1902387 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.0 0.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.0 GO:0005549 odorant binding(GO:0005549) tyrosine binding(GO:0072545)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts