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PRJNA207719: Tissue specific transcriptome profiling

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Results for vsx1_shox_shox2_uncx4.1_lhx2a

Z-value: 0.56

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Transcription factors associated with vsx1_shox_shox2_uncx4.1_lhx2a

Gene Symbol Gene ID Gene Info
ENSDARG00000056292 visual system homeobox 1 homolog, chx10-like
ENSDARG00000109766 visual system homeobox 1 homolog, chx10-like
ENSDARG00000025891 short stature homeobox
ENSDARG00000075713 short stature homeobox 2
ENSDARG00000037760 Unc4.1 homeobox (C. elegans)
ENSDARG00000037964 LIM homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
shox2dr11_v1_chr15_-_2188332_21884220.922.5e-02Click!
uncx4.1dr11_v1_chr1_+_9290103_92901030.828.9e-02Click!
shoxdr11_v1_chr9_+_34641237_346412370.801.0e-01Click!
vsx1dr11_v1_chr17_-_21066075_210661050.682.0e-01Click!

Activity profile of vsx1_shox_shox2_uncx4.1_lhx2a motif

Sorted Z-values of vsx1_shox_shox2_uncx4.1_lhx2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_50608099 1.02 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr13_+_38430466 0.76 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr5_+_64732270 0.74 ENSDART00000134241
olfactomedin 1a
chr16_+_5774977 0.74 ENSDART00000134202
cholecystokinin a
chr4_+_21129752 0.74 ENSDART00000169764
synaptotagmin Ia
chr9_-_20372977 0.71 ENSDART00000113418
immunoglobulin superfamily, member 3
chr23_+_40460333 0.71 ENSDART00000184658
SOGA family member 3b
chr5_+_64732036 0.69 ENSDART00000073950
olfactomedin 1a
chr20_-_45060241 0.67 ENSDART00000185227
kelch-like family member 29
chr6_+_39232245 0.66 ENSDART00000187351
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr19_-_20113696 0.61 ENSDART00000188813
neuropeptide Y
chr20_-_29864390 0.60 ENSDART00000161834
ENSDART00000132278
ring finger protein 144ab
chr2_+_20332044 0.57 ENSDART00000112131
phospholipid phosphatase related 4a
chr20_-_9436521 0.54 ENSDART00000133000
zgc:101840
chr15_+_22311803 0.53 ENSDART00000150182
hepatic and glial cell adhesion molecule a
chr17_-_29119362 0.53 ENSDART00000104204
forkhead box G1a
chr15_-_22074315 0.48 ENSDART00000149830
dopamine receptor D2a
chr20_+_18551657 0.46 ENSDART00000147001
si:dkeyp-72h1.1
chr10_+_42423318 0.45 ENSDART00000134282
neuropeptide Y receptor Y8a
chr17_+_23298928 0.45 ENSDART00000153652
zgc:165461
chr6_-_12172424 0.44 ENSDART00000109344
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr18_-_1185772 0.43 ENSDART00000143245
neuroplastin b
chr20_-_32110882 0.43 ENSDART00000030324
glutamate receptor, metabotropic 1a
chr12_+_24342303 0.43 ENSDART00000111239
neurexin 1a
chr4_+_11384891 0.43 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr21_-_18648861 0.41 ENSDART00000112113
si:dkey-112m2.1
chr25_-_20378721 0.40 ENSDART00000181707
potassium channel tetramerization domain containing 15a
chr18_-_2433011 0.40 ENSDART00000181922
ENSDART00000193276

chr18_+_24921587 0.39 ENSDART00000191345
repulsive guidance molecule family member a
chr16_+_2820340 0.39 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
chr3_-_23406964 0.39 ENSDART00000114723
Rap guanine nucleotide exchange factor (GEF)-like 1
chr7_+_30787903 0.38 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr20_+_19238382 0.38 ENSDART00000136757
fibronectin type III domain containing 4a
chr16_+_34531486 0.37 ENSDART00000043291
progestin and adipoQ receptor family member VII, b
chr20_-_28800999 0.37 ENSDART00000049462
RAB15, member RAS oncogene family
chr23_+_20563779 0.37 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr8_-_33114202 0.37 ENSDART00000098840
Ral GEF with PH domain and SH3 binding motif 1
chr12_+_31744217 0.36 ENSDART00000190361
si:dkey-49c17.3
chr25_-_13842618 0.36 ENSDART00000160258
mitogen-activated protein kinase 8 interacting protein 1a
chr16_+_39159752 0.35 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr2_-_30668580 0.34 ENSDART00000087270
catenin (cadherin-associated protein), delta 2b
chr7_-_28148310 0.34 ENSDART00000044208
LIM domain only 1
chr1_-_50859053 0.33 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr15_-_9272328 0.33 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr1_-_42778510 0.33 ENSDART00000190172
leucine rich repeat transmembrane neuronal 1
chr9_-_51436377 0.33 ENSDART00000006612
T-box, brain, 1b
chr11_+_18873619 0.33 ENSDART00000176141
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr9_-_43538328 0.32 ENSDART00000140526
zinc finger protein 385B
chr19_-_10243148 0.31 ENSDART00000148073
shisa family member 7
chr22_-_12160283 0.30 ENSDART00000146785
ENSDART00000128176
transmembrane protein 163b
chr8_-_42238543 0.30 ENSDART00000062697
GDNF family receptor alpha 2a
chr14_-_2933185 0.29 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr5_+_61301525 0.29 ENSDART00000128773
double C2-like domains, beta
chr1_+_18811679 0.29 ENSDART00000078610
solute carrier family 25, member 51a
chr3_+_32365811 0.29 ENSDART00000155967
adaptor-related protein complex 2, alpha 1 subunit
chr9_+_25776971 0.29 ENSDART00000146011
zinc finger E-box binding homeobox 2a
chr6_+_3828560 0.29 ENSDART00000185273
ENSDART00000179091
glutamate decarboxylase 1b
chr21_+_28958471 0.28 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr11_+_18873113 0.28 ENSDART00000103969
ENSDART00000103968
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr11_-_37509001 0.28 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr4_+_9400012 0.27 ENSDART00000191960
transmembrane and tetratricopeptide repeat containing 1
chr21_+_39705483 0.27 ENSDART00000147718
ENSDART00000168996
PITP-less RdgB-like protein
chr19_+_21362553 0.27 ENSDART00000122002
teashirt zinc finger homeobox 1
chr4_-_1801519 0.27 ENSDART00000188604
ENSDART00000135749
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr4_+_12615836 0.27 ENSDART00000003583
LIM domain only 3
chr23_+_44741500 0.27 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr3_-_46811611 0.26 ENSDART00000134092
ELAV like neuron-specific RNA binding protein 3
chr17_-_12389259 0.26 ENSDART00000185724
synaptosomal-associated protein, 25b
chr16_+_46111849 0.26 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr23_+_28582865 0.26 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr21_+_32820175 0.26 ENSDART00000076903
adrenergic, alpha-2D-, receptor b
chr7_+_32722227 0.26 ENSDART00000126565
si:ch211-150g13.3
chr5_-_12219572 0.26 ENSDART00000167834
nitric oxide synthase 1 (neuronal)
chr22_-_20166660 0.25 ENSDART00000085913
ENSDART00000188241
BTB (POZ) domain containing 2a
chr24_+_16547035 0.25 ENSDART00000164319
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr14_+_45406299 0.24 ENSDART00000173142
ENSDART00000112377
microtubule-associated protein 1 light chain 3 gamma, like
chr13_-_44630111 0.24 ENSDART00000110092
MAM domain containing glycosylphosphatidylinositol anchor 1
chr19_-_32710922 0.24 ENSDART00000004034
hippocalcin
chr12_-_33972798 0.24 ENSDART00000105545
ADP-ribosylation factor-like 3
chr16_+_20161805 0.23 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr4_+_12612145 0.23 ENSDART00000181201
LIM domain only 3
chr14_+_25817628 0.23 ENSDART00000047680
glycine receptor, alpha 1
chr20_-_28642061 0.23 ENSDART00000135513
regulator of G protein signaling 6
chr19_-_30510259 0.23 ENSDART00000135128
ENSDART00000186169
ENSDART00000182974
ENSDART00000187797
BCL2 associated athanogene 6, like
chr22_-_7129631 0.23 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr9_-_12424791 0.23 ENSDART00000135447
ENSDART00000088199
zgc:162707
chr9_-_31278048 0.23 ENSDART00000022204
zic family member 5 (odd-paired homolog, Drosophila)
chr2_+_22702488 0.22 ENSDART00000076647
kinesin family member 1Ab
chr6_-_6487876 0.22 ENSDART00000137642
centrosomal protein 170Ab
chr11_+_38280454 0.22 ENSDART00000171496
si:dkey-166c18.1
chr8_+_16025554 0.22 ENSDART00000110171
ELAV like neuron-specific RNA binding protein 4
chr13_-_37545487 0.21 ENSDART00000131269
synaptotagmin XVI
chr14_-_30587814 0.21 ENSDART00000144912
ENSDART00000149714
transmembrane protein 265
chr20_+_32523576 0.21 ENSDART00000147319
Scm polycomb group protein like 4
chr4_-_15420452 0.21 ENSDART00000016230
plexin A4
chr1_-_47071979 0.21 ENSDART00000160817
intersectin 1 (SH3 domain protein)
chr5_+_21144269 0.20 ENSDART00000028087
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr11_+_28476298 0.20 ENSDART00000122319
leucine rich repeat containing 38b
chr17_+_24722646 0.20 ENSDART00000138356
mitochondrial fission regulator 1-like
chr7_-_23996133 0.20 ENSDART00000173761
si:dkey-183c6.8
chr11_+_24620742 0.20 ENSDART00000182471
ENSDART00000048365
synaptotagmin VIb
chr5_-_41307550 0.20 ENSDART00000143446
natriuretic peptide receptor 3
chr15_-_16177603 0.20 ENSDART00000156352
si:ch211-259g3.4
chr19_-_32641725 0.19 ENSDART00000165006
ENSDART00000188185
hippocalcin
chr12_+_18681477 0.19 ENSDART00000127981
ENSDART00000143979
regulator of G protein signaling 9b
chr4_+_72723304 0.19 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
RAB3A interacting protein (rabin3)
chr11_+_30057762 0.19 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr3_+_33341640 0.19 ENSDART00000186352
peptide YYa
chr18_+_17827149 0.19 ENSDART00000190237
ENSDART00000189345
si:ch211-216l23.1
chr8_-_19051906 0.19 ENSDART00000089024
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr24_-_21923930 0.19 ENSDART00000131944
transgelin 3b
chr22_+_5176693 0.19 ENSDART00000160927
ceramide synthase 1
chr13_-_36911118 0.19 ENSDART00000048739
tripartite motif containing 9
chr12_+_47698356 0.19 ENSDART00000112010
leucine zipper, putative tumor suppressor 2b
chr24_-_31843173 0.18 ENSDART00000185782
STEAP family member 2, metalloreductase
chr13_+_25720969 0.18 ENSDART00000046050
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr14_+_8940326 0.18 ENSDART00000159920
ribosomal protein S6 kinase a, like
chr15_-_6247775 0.18 ENSDART00000148350
Down syndrome cell adhesion molecule b
chr4_-_17629444 0.18 ENSDART00000108814
nuclear receptor interacting protein 2
chr21_-_39177564 0.18 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr19_-_5103141 0.18 ENSDART00000150952
triosephosphate isomerase 1a
chr1_-_36152131 0.18 ENSDART00000182113
ENSDART00000182904
zinc finger protein 827
chr19_-_27261102 0.18 ENSDART00000143919
gamma-aminobutyric acid (GABA) B receptor, 1b
chr3_-_39695856 0.17 ENSDART00000148247
B9 protein domain 1
chr22_+_5176255 0.17 ENSDART00000092647
ceramide synthase 1
chr9_+_38372216 0.17 ENSDART00000141895
phospholipase C, delta 4b
chr5_+_30624183 0.17 ENSDART00000141444
ATP-binding cassette, sub-family G (WHITE), member 4a
chr24_-_30862168 0.17 ENSDART00000168540
polypyrimidine tract binding protein 2a
chr8_-_50888806 0.17 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr17_-_200316 0.17 ENSDART00000190561

chr10_-_11261386 0.17 ENSDART00000189946
polypyrimidine tract binding protein 3
chr21_-_25573064 0.17 ENSDART00000134310

chr12_+_2446837 0.17 ENSDART00000112032
si:dkey-191m6.4
chr14_+_34490445 0.17 ENSDART00000132193
ENSDART00000148044
wingless-type MMTV integration site family, member 8a
chr6_-_40352215 0.17 ENSDART00000103992
tubulin tyrosine ligase-like family, member 3
chr17_-_41798856 0.17 ENSDART00000156031
ENSDART00000192801
ENSDART00000180172
ENSDART00000084745
ENSDART00000175577
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr21_-_42100471 0.17 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr11_-_42554290 0.16 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr8_-_37249991 0.16 ENSDART00000189275
ENSDART00000178556
RNA binding motif protein 39b
chr6_-_38419318 0.16 ENSDART00000138026
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr3_+_56366395 0.16 ENSDART00000154367
calcium channel, voltage-dependent, gamma subunit 5b
chr20_-_46362606 0.16 ENSDART00000153087
BCL2 modifying factor 2
chr5_-_21970881 0.16 ENSDART00000182907
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr3_-_36932515 0.16 ENSDART00000111981
ENSDART00000188470
contactin associated protein 1
chr5_-_23280098 0.16 ENSDART00000126540
ENSDART00000051533
proteolipid protein 1b
chr1_-_23110740 0.15 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr9_+_34641237 0.15 ENSDART00000133996
short stature homeobox
chr20_+_41756996 0.15 ENSDART00000186393
family with sequence similarity 184, member A
chr17_-_44247707 0.15 ENSDART00000126097
orthodenticle homeobox 2b
chr1_-_19215336 0.15 ENSDART00000162949
ENSDART00000170680
protein tyrosine phosphatase, receptor type, D, b
chr21_-_25722834 0.15 ENSDART00000101208
abhydrolase domain containing 11
chr15_-_16098531 0.15 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr14_-_33945692 0.15 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr14_-_34026316 0.15 ENSDART00000186062
cytoplasmic FMR1 interacting protein 2
chr14_+_23717165 0.15 ENSDART00000006373
Nedd4 family interacting protein 1
chr7_+_24645186 0.15 ENSDART00000150118
ENSDART00000150233
ENSDART00000087691
glucosidase, beta (bile acid) 2
chr4_+_12612723 0.15 ENSDART00000133767
LIM domain only 3
chr2_+_41526904 0.15 ENSDART00000127520
activin A receptor, type 1 like
chr9_-_32753535 0.15 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr7_-_30174882 0.15 ENSDART00000110409
FERM domain containing 5
chr13_+_2625150 0.14 ENSDART00000164177
phospholipid phosphatase 4
chr15_-_30857350 0.14 ENSDART00000138988
A kinase (PRKA) anchor protein 1b
chr2_-_3678029 0.14 ENSDART00000146861
matrix metallopeptidase 16b (membrane-inserted)
chr17_-_31639845 0.14 ENSDART00000154196
zinc finger protein 839
chr20_-_27711970 0.14 ENSDART00000139637
zinc finger and BTB domain containing 25
chr6_-_40922971 0.14 ENSDART00000155363
SFI1 centrin binding protein
chr10_+_43039947 0.14 ENSDART00000193434
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr3_-_39696066 0.14 ENSDART00000015393
B9 protein domain 1
chr2_-_28085884 0.14 ENSDART00000131506
cadherin 6
chr1_-_44701313 0.14 ENSDART00000193926
si:dkey-28b4.8
chr7_-_24645540 0.14 ENSDART00000147342
GP1 homolog, RAB6A GEF complex partner 1
chr10_+_17371356 0.14 ENSDART00000122663
signal peptide peptidase 3
chr3_+_17537352 0.14 ENSDART00000104549
hypocretin (orexin) neuropeptide precursor
chr6_+_21001264 0.14 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr15_-_20024205 0.14 ENSDART00000161379
autism susceptibility candidate 2b
chr7_+_46368520 0.14 ENSDART00000192821
zinc finger protein 536
chr2_+_6253246 0.14 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr12_+_34953038 0.14 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
QKI, KH domain containing, RNA binding 2
chr4_-_14315855 0.14 ENSDART00000133325
neural EGFL like 2b
chr2_+_51183320 0.14 ENSDART00000167430
leucine rich repeat containing 24
chr23_+_28731379 0.13 ENSDART00000047378
cortistatin
chr19_-_205104 0.13 ENSDART00000011890
zinc finger and BTB domain containing 22a
chr3_+_34919810 0.13 ENSDART00000055264
carbonic anhydrase Xb
chr2_-_11512819 0.13 ENSDART00000142013
proenkephalin a
chr20_+_4060839 0.13 ENSDART00000178565
tripartite motif containing 67
chr3_-_43356082 0.13 ENSDART00000171213
UNC homeobox
chr19_-_5103313 0.13 ENSDART00000037007
triosephosphate isomerase 1a
chr15_+_1796313 0.13 ENSDART00000126253
family with sequence similarity 124B
chr20_-_39271844 0.13 ENSDART00000192708
clusterin
chr18_+_10884996 0.13 ENSDART00000147613
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr11_-_30158191 0.13 ENSDART00000155278
ENSDART00000156121
Scm polycomb group protein like 2
chr16_+_25116827 0.13 ENSDART00000163244
si:ch211-261d7.6
chr2_-_7246848 0.13 ENSDART00000146434
zgc:153115
chr8_-_37249813 0.13 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
RNA binding motif protein 39b
chr20_+_30445971 0.12 ENSDART00000153150
myelin transcription factor 1-like, a
chr2_-_17044959 0.12 ENSDART00000090260
chloride channel, voltage-sensitive 2a
chr21_-_37963141 0.12 ENSDART00000180331
si:dkey-38k9.5
chr10_+_17235370 0.12 ENSDART00000038780
signal peptide peptidase 3
chr9_+_22485343 0.12 ENSDART00000146028
diacylglycerol kinase, gamma
chr23_+_11669109 0.12 ENSDART00000091416
contactin 3a, tandem duplicate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of vsx1_shox_shox2_uncx4.1_lhx2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 0.6 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 0.8 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.3 GO:0060074 synapse maturation(GO:0060074)
0.1 0.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.1 0.4 GO:0043584 nose development(GO:0043584)
0.1 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.3 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.8 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.1 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.1 GO:0042745 circadian sleep/wake cycle process(GO:0022410) circadian sleep/wake cycle(GO:0042745)
0.1 0.2 GO:0007414 axonal defasciculation(GO:0007414)
0.1 0.4 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.2 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.1 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.3 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.3 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.1 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 1.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.2 GO:0015677 copper ion import(GO:0015677)
0.0 0.6 GO:0051481 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.0 0.1 GO:0021742 abducens nucleus development(GO:0021742)
0.0 0.2 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.2 GO:0070206 protein trimerization(GO:0070206) protein homotrimerization(GO:0070207)
0.0 0.1 GO:0097376 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:1903817 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0035902 response to immobilization stress(GO:0035902)
0.0 0.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0060986 negative regulation of peptide secretion(GO:0002792) regulation of endocrine process(GO:0044060) endocrine hormone secretion(GO:0060986) negative regulation of peptide hormone secretion(GO:0090278)
0.0 0.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.1 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.0 0.2 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.0 0.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0021527 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519) spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:1900120 microglial cell activation(GO:0001774) regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.0 0.1 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.1 GO:0031645 negative regulation of B cell proliferation(GO:0030889) negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645) negative regulation of B cell activation(GO:0050869)
0.0 0.7 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.1 GO:2000434 regulation of protein neddylation(GO:2000434)
0.0 0.2 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0046462 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0001964 startle response(GO:0001964)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.2 GO:0007622 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.0 0.3 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.3 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.4 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.1 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.0 0.0 GO:0055071 manganese ion homeostasis(GO:0055071)
0.0 0.4 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.0 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.3 GO:0007631 feeding behavior(GO:0007631)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.0 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.0 0.2 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.0 0.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0034505 tooth mineralization(GO:0034505)
0.0 0.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.6 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.8 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.2 GO:0097189 apoptotic body(GO:0097189)
0.0 0.2 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0070724 BMP receptor complex(GO:0070724)
0.0 0.2 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.6 GO:0043204 perikaryon(GO:0043204)
0.0 0.1 GO:0043194 axon initial segment(GO:0043194)
0.0 0.3 GO:0032590 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 0.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 2.8 GO:0030424 axon(GO:0030424)
0.0 0.2 GO:0043209 myelin sheath(GO:0043209)
0.0 0.1 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.1 0.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.3 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.4 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.2 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1 0.3 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.6 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0015369 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.7 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.1 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.0 0.1 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.6 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions