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PRJNA207719: Tissue specific transcriptome profiling
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Results for xbp1
Z-value: 1.11
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Transcription factors associated with xbp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| xbp1 | dr11_v1_chr5_-_15948833_15948920 | 0.83 | 8.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_23984755 Show fit | 0.65 |
ENSDART00000145328
|
apolipoprotein C-II |
|
| chr4_+_68562464 Show fit | 0.60 |
ENSDART00000192954
|
|
|
| chr16_+_27224369 Show fit | 0.60 |
ENSDART00000136980
|
Sec61 translocon beta subunit |
|
| chr16_+_23984179 Show fit | 0.44 |
ENSDART00000175879
|
apolipoprotein C-II |
|
| chr7_+_10610791 Show fit | 0.43 |
ENSDART00000166064
|
fumarylacetoacetate hydrolase (fumarylacetoacetase) |
|
| chr3_-_25377163 Show fit | 0.42 |
ENSDART00000055490
|
karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
|
| chr16_-_46660680 Show fit | 0.42 |
ENSDART00000159209
ENSDART00000191929 |
transmembrane protein 176l.4 |
|
| chr12_-_990149 Show fit | 0.37 |
ENSDART00000054367
|
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b |
|
| chr21_+_10701834 Show fit | 0.33 |
ENSDART00000192473
|
lectin, mannose-binding, 1 |
|
| chr6_+_13506841 Show fit | 0.32 |
ENSDART00000032331
|
GDP-mannose pyrophosphorylase Ab |
Network of associatons between targets according to the STRING database.
First level regulatory network of xbp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.1 | 1.1 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.1 | 0.9 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.1 | 0.5 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.1 | 0.5 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.1 | 0.5 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.1 | 0.4 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 0.4 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.4 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 0.3 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.2 | 0.9 | GO:0005784 | Sec61 translocon complex(GO:0005784) |
| 0.0 | 0.7 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.2 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.0 | 0.2 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 0.0 | 0.2 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.2 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.2 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 0.1 | GO:0005828 | kinetochore microtubule(GO:0005828) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 0.5 | GO:0051748 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.1 | 0.5 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.1 | 0.4 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 0.4 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.0 | 0.4 | GO:0061608 | nuclear import signal receptor activity(GO:0061608) |
| 0.1 | 0.3 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.1 | 0.3 | GO:0008905 | mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905) |
| 0.1 | 0.3 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.1 | 0.3 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 1.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.9 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 0.5 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.3 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |