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PRJNA207719: Tissue specific transcriptome profiling
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Results for yy1a+yy1b
Z-value: 4.70
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Transcription factors associated with yy1a+yy1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| yy1a | dr11_v1_chr17_-_30863252_30863252 | 0.72 | 1.7e-01 | Click! |
| yy1b | dr11_v1_chr20_-_54435287_54435287 | 0.56 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_4915118 Show fit | 3.72 |
ENSDART00000060714
|
ATPase H+ transporting accessory protein 1a |
|
| chr23_+_36771593 Show fit | 3.44 |
ENSDART00000078240
|
membrane-associated ring finger (C3HC4) 9 |
|
| chr2_+_5621529 Show fit | 3.42 |
ENSDART00000144187
|
fibroblast growth factor 12a |
|
| chr24_-_6158933 Show fit | 3.27 |
ENSDART00000021609
|
glutamate decarboxylase 2 |
|
| chr24_-_24848612 Show fit | 3.25 |
ENSDART00000190941
|
corticotropin releasing hormone b |
|
| chr2_+_50862527 Show fit | 3.06 |
ENSDART00000169800
ENSDART00000158847 ENSDART00000160900 |
adenylate cyclase activating polypeptide 1a (pituitary) receptor type I |
|
| chr4_+_19535946 Show fit | 2.99 |
ENSDART00000192342
ENSDART00000183740 ENSDART00000180812 ENSDART00000180017 |
leucine rich repeat containing 4.1 |
|
| chr5_-_29643381 Show fit | 2.91 |
ENSDART00000034849
|
glutamate receptor, ionotropic, N-methyl D-aspartate 1b |
|
| chr21_+_11468934 Show fit | 2.80 |
ENSDART00000126045
ENSDART00000129744 ENSDART00000102368 |
glutamate receptor, ionotropic, N-methyl D-aspartate 1a |
|
| chr6_-_51101834 Show fit | 2.71 |
ENSDART00000092493
|
protein tyrosine phosphatase, receptor type, t |
Network of associatons between targets according to the STRING database.
First level regulatory network of yy1a+yy1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 0.5 | 8.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 7.0 | GO:0070509 | calcium ion import(GO:0070509) |
| 0.1 | 6.6 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.1 | 6.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 5.7 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.2 | 5.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 5.5 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.2 | 5.2 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 5.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 53.7 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 15.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 8.7 | GO:0032589 | neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590) |
| 0.2 | 7.3 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 6.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 6.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 6.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 6.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.4 | 6.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 5.1 | GO:0005605 | basal lamina(GO:0005605) laminin complex(GO:0043256) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 10.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 8.2 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 8.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 7.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 6.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 6.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.3 | 6.0 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 5.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 5.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.9 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 2.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.2 | 2.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 2.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 2.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 5.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 4.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.8 | 3.2 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 3.1 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 2.9 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 2.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.8 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.1 | 2.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |