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PRJNA207719: Tissue specific transcriptome profiling
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Results for zbtb14
Z-value: 5.04
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Transcription factors associated with zbtb14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zbtb14 | dr11_v1_chr24_+_41989108_41989108 | 0.83 | 8.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_25649626 Show fit | 7.24 |
ENSDART00000146947
|
tachykinin 1 |
|
| chr1_-_56223913 Show fit | 5.37 |
ENSDART00000019573
|
zgc:65894 |
|
| chr25_+_14165447 Show fit | 5.12 |
ENSDART00000145387
|
SH3 and multiple ankyrin repeat domains 2 |
|
| chr1_+_53321878 Show fit | 5.02 |
ENSDART00000143909
|
TBC1 domain family, member 9 (with GRAM domain) |
|
| chr4_-_797831 Show fit | 4.86 |
ENSDART00000158970
ENSDART00000170012 |
microtubule-associated protein, RP/EB family, member 3b |
|
| chr16_-_43026273 Show fit | 4.70 |
ENSDART00000156820
ENSDART00000189080 |
si:dkey-7j14.5 |
|
| chr23_+_44732863 Show fit | 4.35 |
ENSDART00000160044
ENSDART00000172268 |
ATPase Na+/K+ transporting subunit beta 2a |
|
| chr7_+_73332486 Show fit | 4.30 |
ENSDART00000174119
ENSDART00000092051 ENSDART00000192388 |
|
|
| chr21_+_11468934 Show fit | 4.26 |
ENSDART00000126045
ENSDART00000129744 ENSDART00000102368 |
glutamate receptor, ionotropic, N-methyl D-aspartate 1a |
|
| chr22_-_21150845 Show fit | 4.17 |
ENSDART00000027345
|
transmembrane protein 59-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of zbtb14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.7 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.2 | 9.6 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.5 | 8.4 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.9 | 7.8 | GO:0035372 | protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825) |
| 1.4 | 7.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.1 | 7.0 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.4 | 5.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 5.9 | GO:0048675 | axon extension(GO:0048675) |
| 0.3 | 5.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 5.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 8.9 | GO:0034703 | cation channel complex(GO:0034703) |
| 0.1 | 8.7 | GO:0099572 | postsynaptic specialization(GO:0099572) |
| 0.0 | 8.1 | GO:0005874 | microtubule(GO:0005874) |
| 0.0 | 8.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 7.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 7.6 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.3 | 7.4 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.5 | 7.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 6.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 9.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 8.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.4 | 7.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 2.4 | 7.2 | GO:0031835 | neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835) |
| 0.0 | 7.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 7.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.5 | 6.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 6.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 5.6 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 2.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.6 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 1.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 3.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 3.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 2.9 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 2.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 2.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.2 | 2.2 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 2.1 | REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 1.8 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |