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PRJNA207719: Tissue specific transcriptome profiling
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Results for zeb1a+zeb1b
Z-value: 4.85
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Transcription factors associated with zeb1a+zeb1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zeb1b | dr11_v1_chr12_-_26851726_26851726 | -0.85 | 7.0e-02 | Click! |
| zeb1a | dr11_v1_chr2_-_43850637_43850637 | -0.75 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_20239141 Show fit | 6.92 |
ENSDART00000101152
ENSDART00000152473 |
serine peptidase inhibitor, Kunitz type, 2 |
|
| chr22_+_661711 Show fit | 4.88 |
ENSDART00000113795
|
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
|
| chr19_-_30404096 Show fit | 4.75 |
ENSDART00000103475
|
anterior gradient 2 |
|
| chr2_+_68789 Show fit | 4.58 |
ENSDART00000058569
|
claudin 1 |
|
| chr22_+_7439476 Show fit | 4.51 |
ENSDART00000021594
ENSDART00000063389 |
zgc:92041 |
|
| chr22_+_1170294 Show fit | 4.47 |
ENSDART00000159761
ENSDART00000169809 |
interferon regulatory factor 6 |
|
| chr10_-_2942900 Show fit | 4.25 |
ENSDART00000002622
|
occludin a |
|
| chr6_-_7776612 Show fit | 4.20 |
ENSDART00000190269
|
myosin, heavy chain 9a, non-muscle |
|
| chr21_-_38153824 Show fit | 3.90 |
ENSDART00000151226
|
Kruppel-like factor 5 like |
|
| chr19_-_30403922 Show fit | 3.87 |
ENSDART00000181841
|
anterior gradient 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of zeb1a+zeb1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.2 | GO:0006508 | proteolysis(GO:0006508) |
| 0.1 | 14.1 | GO:1990266 | neutrophil migration(GO:1990266) |
| 0.2 | 11.5 | GO:0043297 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.9 | 8.6 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.0 | 8.2 | GO:0006412 | translation(GO:0006412) |
| 0.1 | 7.3 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.4 | 6.1 | GO:2000344 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 5.9 | GO:0007492 | endoderm development(GO:0007492) |
| 0.0 | 5.8 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 5.6 | GO:0045087 | innate immune response(GO:0045087) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 39.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 18.8 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 13.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.7 | 8.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 8.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 8.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 7.6 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.3 | 5.8 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 4.9 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 4.9 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.3 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.1 | 30.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 17.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 11.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 11.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 10.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 7.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.1 | 5.3 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.5 | 5.2 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 4.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.9 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 2.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 2.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 2.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 2.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 4.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 4.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 4.2 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.2 | 4.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 4.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.8 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.4 | 2.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.8 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 2.8 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |