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PRJNA207719: Tissue specific transcriptome profiling

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Results for zfhx3+zfhx3a+zfhx4

Z-value: 1.15

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Transcription factors associated with zfhx3+zfhx3a+zfhx4

Gene Symbol Gene ID Gene Info
zfhx3a
ENSDARG00000073944 si_ch73-386h18.1
zfhx4
ENSDARG00000075542 zinc finger homeobox 4
zfhx3
ENSDARG00000103057 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zfhx3dr11_v1_chr7_-_68373495_68373495-0.701.9e-01Click!
zfhx4dr11_v1_chr24_-_23323526_23323526-0.326.0e-01Click!
si:ch73-386h18.1dr11_v1_chr18_+_6054816_6054816-0.306.3e-01Click!

Activity profile of zfhx3+zfhx3a+zfhx4 motif

Sorted Z-values of zfhx3+zfhx3a+zfhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_24791505 1.52 ENSDART00000136837
vtg4
vitellogenin 4
chr7_+_56577522 1.31 ENSDART00000149130
ENSDART00000149624
hp
haptoglobin
chr20_-_40754794 1.28 ENSDART00000187251
cx32.3
connexin 32.3
chr5_+_32345187 1.23 ENSDART00000147132
c9
complement component 9
chr22_-_24818066 1.10 ENSDART00000143443
vtg6
vitellogenin 6
chr7_+_56577906 1.09 ENSDART00000184023
hp
haptoglobin
chr5_+_28797771 1.08 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
si:ch211-186e20.7
chr6_-_40058686 0.91 ENSDART00000103240
uroc1
urocanate hydratase 1
chr5_+_28830643 0.86 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_28830388 0.85 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr20_-_40755614 0.83 ENSDART00000061247
cx32.3
connexin 32.3
chr20_-_40750953 0.81 ENSDART00000061256
cx28.9
connexin 28.9
chr8_-_18042089 0.81 ENSDART00000132596
dio1
iodothyronine deiodinase 1
chr5_+_28848870 0.80 ENSDART00000149563
zgc:174259
zgc:174259
chr5_+_28849155 0.79 ENSDART00000079090
zgc:174259
zgc:174259
chr22_+_20720808 0.73 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr5_+_28858345 0.65 ENSDART00000111180
si:ch211-186e20.2
si:ch211-186e20.2
chr16_-_25608453 0.65 ENSDART00000140140
zgc:110410
zgc:110410
chr18_+_15644559 0.59 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr4_+_18804317 0.57 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr6_-_58764672 0.51 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr7_-_4296771 0.46 ENSDART00000128855
cbln11
cerebellin 11
chr25_-_35599887 0.43 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr16_-_27566552 0.34 ENSDART00000142102
zgc:153215
zgc:153215
chr23_+_20689255 0.34 ENSDART00000182420
usp21
ubiquitin specific peptidase 21
chr21_-_20765338 0.34 ENSDART00000135940
ghrb
growth hormone receptor b
chr19_-_3056235 0.33 ENSDART00000137020
bop1
block of proliferation 1
chr17_+_8212477 0.32 ENSDART00000064665
slc18b1
solute carrier family 18, subfamily B, member 1
chr9_-_14143370 0.32 ENSDART00000108950
ttll4
tubulin tyrosine ligase-like family, member 4
chr16_-_31351419 0.31 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr12_+_47081783 0.30 ENSDART00000158568
mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
chr4_+_57881965 0.30 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr8_+_15254564 0.28 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr20_+_36629173 0.28 ENSDART00000161241
ephx1
epoxide hydrolase 1, microsomal (xenobiotic)
chr18_-_22713402 0.28 ENSDART00000145871
si:ch73-113g13.2
si:ch73-113g13.2
chr8_-_20230559 0.27 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr9_+_21151138 0.26 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr6_-_32349153 0.26 ENSDART00000140004
angptl3
angiopoietin-like 3
chr1_+_44003654 0.25 ENSDART00000131337
si:dkey-22i16.10
si:dkey-22i16.10
chr17_+_8799451 0.24 ENSDART00000189814
ENSDART00000191577
tonsl
tonsoku-like, DNA repair protein
chr19_+_19761966 0.24 ENSDART00000163697
hoxa3a
homeobox A3a
chr18_-_22713621 0.22 ENSDART00000079013
si:ch73-113g13.2
si:ch73-113g13.2
chr20_-_15089738 0.22 ENSDART00000164552
si:dkey-239i20.2
si:dkey-239i20.2
chr3_-_34066548 0.22 ENSDART00000151302
ighv9-2
immunoglobulin heavy variable 9-2
chr17_+_8799661 0.21 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr22_-_294700 0.21 ENSDART00000189179
CABZ01079179.1

chr5_-_44829719 0.21 ENSDART00000019104
fbp2
fructose-1,6-bisphosphatase 2
chr5_+_9382301 0.21 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr23_+_24589633 0.21 ENSDART00000143694
mlh3
mutL homolog 3 (E. coli)
chr5_-_34875858 0.20 ENSDART00000085086
arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr22_+_13886821 0.20 ENSDART00000130585
ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr5_+_6954162 0.19 ENSDART00000086666
stpg2
sperm-tail PG-rich repeat containing 2
chr12_+_46582727 0.19 ENSDART00000149326
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr17_+_2162916 0.19 ENSDART00000103775
pak6a
p21 protein (Cdc42/Rac)-activated kinase 6a
chr5_-_30620625 0.19 ENSDART00000098273
tcnl
transcobalamin like
chr25_+_29474583 0.19 ENSDART00000191189
il17rel
interleukin 17 receptor E-like
chr16_-_55259199 0.19 ENSDART00000161130
iqgap3
IQ motif containing GTPase activating protein 3
chr23_+_21473103 0.18 ENSDART00000142921
si:ch73-21g5.7
si:ch73-21g5.7
chr23_-_41965557 0.18 ENSDART00000144183
slc1a7b
solute carrier family 1 (glutamate transporter), member 7b
chr16_-_42894628 0.17 ENSDART00000045600
hfe2
hemochromatosis type 2
chr18_+_7611298 0.16 ENSDART00000062156
odf3b
outer dense fiber of sperm tails 3B
chr14_-_7207961 0.16 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr4_-_20118468 0.16 ENSDART00000078587
si:dkey-159a18.1
si:dkey-159a18.1
chr25_+_34915762 0.15 ENSDART00000191776
sntb2
syntrophin, beta 2
chr18_+_36914221 0.15 ENSDART00000147656
si:ch211-238g23.1
si:ch211-238g23.1
chr10_+_8690936 0.15 ENSDART00000144218
si:dkey-27b3.4
si:dkey-27b3.4
chr8_+_10339869 0.15 ENSDART00000132253
tbc1d22b
TBC1 domain family, member 22B
chr15_+_38299385 0.13 ENSDART00000142403
si:dkey-24p1.6
si:dkey-24p1.6
chr24_-_2450597 0.13 ENSDART00000188080
ENSDART00000093331
rreb1a
ras responsive element binding protein 1a
chr11_+_23760470 0.13 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
nfasca
neurofascin homolog (chicken) a
chr15_+_38299563 0.13 ENSDART00000099375
si:dkey-24p1.6
si:dkey-24p1.6
chr3_-_30388525 0.12 ENSDART00000183790
lrrc4ba
leucine rich repeat containing 4Ba
chr8_+_1839695 0.12 ENSDART00000148254
ENSDART00000143473
snap29
synaptosomal-associated protein 29
chr12_+_30788912 0.11 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr10_+_8197827 0.11 ENSDART00000026244
mtrex
Mtr4 exosome RNA helicase
chr8_-_20230802 0.11 ENSDART00000063400
mllt1a
MLLT1, super elongation complex subunit a
chr15_+_34988148 0.11 ENSDART00000076269
ccdc105
coiled-coil domain containing 105
chr20_-_25481306 0.11 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr13_+_45524475 0.10 ENSDART00000074567
ENSDART00000019113
maco1b
macoilin 1b
chr11_-_2838699 0.10 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr19_+_20274491 0.09 ENSDART00000090860
ENSDART00000151693
oxnad1
oxidoreductase NAD-binding domain containing 1
chr25_+_28679672 0.09 ENSDART00000139965
ENSDART00000134072
cnot2
CCR4-NOT transcription complex, subunit 2
chr20_-_9095105 0.08 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr24_+_26329018 0.08 ENSDART00000145752
mynn
myoneurin
chr1_+_44838706 0.07 ENSDART00000162779
ENSDART00000147357
kdm2aa
lysine (K)-specific demethylase 2Aa
chr15_-_17869115 0.07 ENSDART00000112838
atf5b
activating transcription factor 5b
chr9_+_45227028 0.07 ENSDART00000185579
adarb1b
adenosine deaminase, RNA-specific, B1b
chr15_-_17868870 0.07 ENSDART00000170950
atf5b
activating transcription factor 5b
chr25_+_34915576 0.07 ENSDART00000073441
sntb2
syntrophin, beta 2
chr17_-_24820801 0.07 ENSDART00000156606
trmt61b
tRNA methyltransferase 61B
chr20_-_38617766 0.06 ENSDART00000050474
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr24_-_26328721 0.06 ENSDART00000125468
apodb
apolipoprotein Db
chr14_+_8594367 0.06 ENSDART00000037749
stx5a
syntaxin 5A
chr13_+_25286538 0.06 ENSDART00000180282
chuk
conserved helix-loop-helix ubiquitous kinase
chr16_+_24733741 0.05 ENSDART00000155217
si:dkey-79d12.4
si:dkey-79d12.4
chr22_+_14836291 0.05 ENSDART00000122740
gtpbp1l
GTP binding protein 1, like
chr25_-_16818380 0.05 ENSDART00000155401
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr12_-_18578218 0.05 ENSDART00000125803
zdhhc4
zinc finger, DHHC-type containing 4
chr17_+_9310259 0.04 ENSDART00000186158
ENSDART00000190329
NPAS3
neuronal PAS domain protein 3
chr8_-_25569920 0.04 ENSDART00000136869
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr3_-_5228137 0.04 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr4_-_22338906 0.04 ENSDART00000131402
golgb1
golgin B1
chr7_+_42460302 0.04 ENSDART00000004120
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr21_+_37513488 0.04 ENSDART00000185394
amot
angiomotin
chr1_+_54013457 0.04 ENSDART00000012104
ENSDART00000126339
dla
deltaA
chr2_-_7845110 0.04 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr12_-_18578432 0.03 ENSDART00000122858
zdhhc4
zinc finger, DHHC-type containing 4
chr14_+_10596628 0.03 ENSDART00000115177
gpr174
G protein-coupled receptor 174
chr12_+_27061720 0.03 ENSDART00000153426
srcap
Snf2-related CREBBP activator protein
chr16_-_41787421 0.03 ENSDART00000147210
si:dkey-199f5.8
si:dkey-199f5.8
chr6_+_30456788 0.03 ENSDART00000121492
FP236735.1

chr21_-_13123176 0.02 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr5_+_9224051 0.01 ENSDART00000139265
si:ch211-12e13.12
si:ch211-12e13.12
chr17_+_31914877 0.01 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr1_+_26480890 0.01 ENSDART00000164430
uso1
USO1 vesicle transport factor
chr25_-_16818195 0.01 ENSDART00000185215
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr6_-_43283122 0.00 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr16_-_9675982 0.00 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)

Network of associatons between targets according to the STRING database.

First level regulatory network of zfhx3+zfhx3a+zfhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 0.9 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.3 0.3 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 0.8 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.1 2.6 GO:0032355 response to estradiol(GO:0032355)
0.1 5.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 0.5 GO:0034435 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0 0.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.6 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.3 GO:0060416 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:0031297 replication fork processing(GO:0031297)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.3 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0048730 epidermis morphogenesis(GO:0048730)
0.0 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.1 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0045735 nutrient reservoir activity(GO:0045735)
0.1 0.5 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.6 GO:0032052 bile acid binding(GO:0032052)
0.1 0.3 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
0.1 0.3 GO:0004903 growth hormone receptor activity(GO:0004903)
0.1 0.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 5.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism