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PRJNA207719: Tissue specific transcriptome profiling

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Results for zic2a+zic2b

Z-value: 2.05

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Transcription factors associated with zic2a+zic2b

Gene Symbol Gene ID Gene Info
zic2a
ENSDARG00000015554 zic family member 2 (odd-paired homolog, Drosophila), a
zic2b
ENSDARG00000037178 zic family member 2 (odd-paired homolog, Drosophila) b
zic2b
ENSDARG00000112354 zic family member 2 (odd-paired homolog, Drosophila) b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic2adr11_v1_chr9_+_31282161_312821610.884.9e-02Click!
zic2bdr11_v1_chr1_+_29858032_298580320.791.1e-01Click!

Activity profile of zic2a+zic2b motif

Sorted Z-values of zic2a+zic2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_83873 7.95 ENSDART00000162145
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr12_+_47162456 2.60 ENSDART00000186272
ENSDART00000180811
RYR2
ryanodine receptor 2
chr19_+_23982466 2.53 ENSDART00000080673
syt11a
synaptotagmin XIa
chr12_+_47162761 2.47 ENSDART00000192339
ENSDART00000167726
RYR2
ryanodine receptor 2
chr8_+_31119548 2.35 ENSDART00000136578
syn1
synapsin I
chr20_-_915234 1.82 ENSDART00000164816
cnr1
cannabinoid receptor 1
chr11_+_14147913 1.77 ENSDART00000022823
ENSDART00000154329
plppr3b
phospholipid phosphatase related 3b
chr3_-_30118856 1.70 ENSDART00000109953
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr15_+_29085955 1.70 ENSDART00000156799
si:ch211-137a8.4
si:ch211-137a8.4
chr6_+_36942966 1.66 ENSDART00000028895
negr1
neuronal growth regulator 1
chr11_+_40657612 1.63 ENSDART00000183271
slc45a1
solute carrier family 45, member 1
chr11_-_4235811 1.57 ENSDART00000121716
si:ch211-236d3.4
si:ch211-236d3.4
chr21_-_42055872 1.50 ENSDART00000144767
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr21_+_17110598 1.41 ENSDART00000101282
ENSDART00000191864
bcr
breakpoint cluster region
chr3_-_19091024 1.38 ENSDART00000188485
ENSDART00000110554
grin2ca
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr4_+_10365857 1.37 ENSDART00000138890
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr13_-_36911118 1.32 ENSDART00000048739
trim9
tripartite motif containing 9
chr1_+_39597809 1.31 ENSDART00000122700
tenm3
teneurin transmembrane protein 3
chr1_+_25783801 1.30 ENSDART00000102455
gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
chr12_+_42436328 1.30 ENSDART00000167324
ebf3a
early B cell factor 3a
chr1_-_45042210 1.28 ENSDART00000073694
smu1b
SMU1, DNA replication regulator and spliceosomal factor b
chr16_+_29303971 1.27 ENSDART00000087149
hapln2
hyaluronan and proteoglycan link protein 2
chr14_-_40389699 1.24 ENSDART00000181581
ENSDART00000173398
pcdh19
protocadherin 19
chr4_+_10366532 1.21 ENSDART00000189901
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr19_+_9050852 1.20 ENSDART00000151031
ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr11_+_30162407 1.15 ENSDART00000190333
ENSDART00000127502
cdkl5
cyclin-dependent kinase-like 5
chr13_+_3954540 1.13 ENSDART00000092646
lrrc73
leucine rich repeat containing 73
chr7_-_45076131 1.12 ENSDART00000110590
zgc:194678
zgc:194678
chr17_-_36929332 1.10 ENSDART00000183454
dpysl5a
dihydropyrimidinase-like 5a
chr14_+_29609245 1.09 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr15_-_26844591 1.08 ENSDART00000077582
pitpnm3
PITPNM family member 3
chr3_-_62380146 1.08 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr19_-_28360033 1.07 ENSDART00000186994
si:dkey-261i16.5
si:dkey-261i16.5
chr19_-_26235219 1.06 ENSDART00000104008
dtnbp1b
dystrobrevin binding protein 1b
chr15_-_12229874 1.06 ENSDART00000165159
dscaml1
Down syndrome cell adhesion molecule like 1
chr10_+_40235959 1.03 ENSDART00000145862
gramd1ba
GRAM domain containing 1Ba
chr5_-_14564878 1.02 ENSDART00000160511
sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr4_+_4902392 1.00 ENSDART00000133866
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr24_-_21490628 0.99 ENSDART00000181546
atp8a2
ATPase phospholipid transporting 8A2
chr9_-_20372977 0.98 ENSDART00000113418
igsf3
immunoglobulin superfamily, member 3
chr5_-_43959972 0.92 ENSDART00000180517
si:ch211-204c21.1
si:ch211-204c21.1
chr9_+_6082793 0.92 ENSDART00000192045
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr17_-_5769196 0.92 ENSDART00000113885
si:dkey-100n19.2
si:dkey-100n19.2
chr11_-_23025949 0.90 ENSDART00000184859
ENSDART00000167818
ENSDART00000046122
ENSDART00000193120
atp2b2
ATPase plasma membrane Ca2+ transporting 2
chr9_+_24159725 0.87 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr14_+_25465346 0.85 ENSDART00000173436
si:dkey-280e21.3
si:dkey-280e21.3
chr19_-_10196370 0.85 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr5_+_19320554 0.84 ENSDART00000165119
rusc2
RUN and SH3 domain containing 2
chr25_+_19955598 0.84 ENSDART00000091547
kcna1a
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr17_+_23937262 0.81 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr6_-_42073367 0.81 ENSDART00000154304
grm2a
glutamate receptor, metabotropic 2a
chr20_+_26095530 0.80 ENSDART00000139350
syne1a
spectrin repeat containing, nuclear envelope 1a
chr14_-_34026316 0.80 ENSDART00000186062
cyfip2
cytoplasmic FMR1 interacting protein 2
chr9_-_46072805 0.77 ENSDART00000169682
hdac4
histone deacetylase 4
chr21_-_45588720 0.75 ENSDART00000186642
ENSDART00000189531
LO018363.2

chr20_+_1996202 0.74 ENSDART00000184143
CABZ01092781.1

chr2_-_30784502 0.73 ENSDART00000056735
rgs20
regulator of G protein signaling 20
chr18_+_9641210 0.72 ENSDART00000182024
pclob
piccolo presynaptic cytomatrix protein b
chr18_-_40684756 0.72 ENSDART00000113799
ENSDART00000139042
si:ch211-132b12.7
si:ch211-132b12.7
chr2_-_57707039 0.71 ENSDART00000097685
CABZ01060891.1

chr3_+_32443395 0.70 ENSDART00000188447
prr12b
proline rich 12b
chr2_-_12242695 0.69 ENSDART00000158175
gpr158b
G protein-coupled receptor 158b
chr22_-_24858042 0.69 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vtg7
vitellogenin 7
chr4_-_2219705 0.67 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr5_+_52844681 0.67 ENSDART00000162459
ENSDART00000184914
scarb2a
scavenger receptor class B, member 2a
chr11_+_41560792 0.65 ENSDART00000127292
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr22_+_28818291 0.64 ENSDART00000136032
tp53bp2b
tumor protein p53 binding protein, 2b
chr2_-_30784198 0.64 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr16_+_32559821 0.63 ENSDART00000093250
pou3f2b
POU class 3 homeobox 2b
chr3_-_37351225 0.63 ENSDART00000174685
si:ch211-278a6.1
si:ch211-278a6.1
chr14_+_24935131 0.62 ENSDART00000170871
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr20_-_7000225 0.62 ENSDART00000100098
adcy1a
adenylate cyclase 1a
chr23_+_31000243 0.59 ENSDART00000085263
selenoi
selenoprotein I
chr6_+_60055168 0.59 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr18_+_9637744 0.59 ENSDART00000190171
pclob
piccolo presynaptic cytomatrix protein b
chr3_-_25814097 0.58 ENSDART00000169706
ntn1b
netrin 1b
chr23_+_20422661 0.57 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr16_-_2558653 0.55 ENSDART00000110365
adcy3a
adenylate cyclase 3a
chr11_-_41130239 0.55 ENSDART00000173268
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr10_+_2876020 0.55 ENSDART00000136618
ENSDART00000133128
ENSDART00000140803
ENSDART00000141505
ccar2
cell cycle and apoptosis regulator 2
chr2_+_26656283 0.55 ENSDART00000133202
ENSDART00000099208
asph
aspartate beta-hydroxylase
chr5_-_30151815 0.53 ENSDART00000156048
zbtb44
zinc finger and BTB domain containing 44
chr5_-_58112032 0.53 ENSDART00000016418
drd2b
dopamine receptor D2b
chr19_-_46566430 0.52 ENSDART00000166668
ext1b
exostosin glycosyltransferase 1b
chr4_+_6840223 0.51 ENSDART00000161329
dock4b
dedicator of cytokinesis 4b
chr9_+_54417141 0.50 ENSDART00000056810
drd1b
dopamine receptor D1b
chr22_-_37611681 0.48 ENSDART00000028085
ttc14
tetratricopeptide repeat domain 14
chr18_-_29972709 0.48 ENSDART00000131207
si:ch211-220f16.2
si:ch211-220f16.2
chr3_+_33745014 0.47 ENSDART00000159966
nacc1a
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing a
chr14_-_14705750 0.46 ENSDART00000168092
ogt.1
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr22_+_38173960 0.46 ENSDART00000010537
cp
ceruloplasmin
chr7_-_22632938 0.46 ENSDART00000159867
ENSDART00000165706
si:dkey-112a7.4
si:dkey-112a7.4
chr2_-_33993533 0.45 ENSDART00000140910
ENSDART00000077304
ptch2
patched 2
chr14_-_14705335 0.44 ENSDART00000157392
ENSDART00000159456
ogt.1
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr9_-_128036 0.44 ENSDART00000165960
FQ377903.2

chr2_+_3516913 0.43 ENSDART00000109346
CU693445.1

chr24_+_3972260 0.43 ENSDART00000131753
pfkpa
phosphofructokinase, platelet a
chr6_+_7553085 0.42 ENSDART00000150939
ENSDART00000151114
myh10
myosin, heavy chain 10, non-muscle
chr18_+_17827149 0.42 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr17_-_1407593 0.42 ENSDART00000157622
ENSDART00000159458
zbtb42
zinc finger and BTB domain containing 42
chr5_+_13521081 0.42 ENSDART00000171975
si:ch211-230g14.6
si:ch211-230g14.6
chr8_+_26226044 0.42 ENSDART00000186503
wdr6
WD repeat domain 6
chr25_-_28384954 0.40 ENSDART00000073500
ptprz1a
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr10_-_27197044 0.40 ENSDART00000137928
auts2a
autism susceptibility candidate 2a
chr20_-_25669813 0.39 ENSDART00000153118
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr25_+_26923193 0.39 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr20_-_36671660 0.39 ENSDART00000134819
slc5a6a
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6a
chr21_-_30415524 0.37 ENSDART00000101036
grpel2
GrpE-like 2, mitochondrial
chr11_+_3006124 0.37 ENSDART00000126071
cpne5b
copine Vb
chr21_-_5856050 0.36 ENSDART00000115367
CABZ01071020.1

chr17_-_7371564 0.35 ENSDART00000060336
rab32b
RAB32b, member RAS oncogene family
chr5_+_7393346 0.35 ENSDART00000164238
si:ch73-72b7.1
si:ch73-72b7.1
chr21_+_39963851 0.35 ENSDART00000144435
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr7_-_35126374 0.35 ENSDART00000141211
hsd11b2
hydroxysteroid (11-beta) dehydrogenase 2
chr12_-_6905375 0.35 ENSDART00000152322
pcdh15b
protocadherin-related 15b
chr7_+_13464878 0.34 ENSDART00000172969
dagla
diacylglycerol lipase, alpha
chr14_-_10371638 0.33 ENSDART00000003879
fam199x
family with sequence similarity 199, X-linked
chr15_+_816556 0.33 ENSDART00000046783
zgc:113294
zgc:113294
chr5_-_48070779 0.33 ENSDART00000078401
tmem161b
transmembrane protein 161B
chr22_+_2686673 0.32 ENSDART00000161580
si:dkey-20i20.15
si:dkey-20i20.15
chr13_-_30150592 0.32 ENSDART00000143093
sar1ab
secretion associated, Ras related GTPase 1Ab
chr4_+_38937575 0.32 ENSDART00000150385
znf997
zinc finger protein 997
chr14_+_25464681 0.31 ENSDART00000067500
ENSDART00000187601
si:dkey-280e21.3
si:dkey-280e21.3
chr13_+_42124566 0.31 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr15_+_26941063 0.31 ENSDART00000149957
bcas3
breast carcinoma amplified sequence 3
chr21_-_45073764 0.30 ENSDART00000181390
ENSDART00000063714
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr1_-_18446161 0.30 ENSDART00000089442
klhl5
kelch-like family member 5
chr5_+_17727310 0.30 ENSDART00000147657
fbrsl1
fibrosin-like 1
chr22_-_24818066 0.30 ENSDART00000143443
vtg6
vitellogenin 6
chr23_+_31979602 0.28 ENSDART00000140351
pan2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr4_-_75175407 0.28 ENSDART00000180125
CABZ01043953.1

chr20_-_45060241 0.28 ENSDART00000185227
klhl29
kelch-like family member 29
chr9_+_14023386 0.28 ENSDART00000140199
ENSDART00000124267
si:ch211-67e16.4
si:ch211-67e16.4
chr6_-_35106425 0.28 ENSDART00000165139
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr16_+_54263921 0.27 ENSDART00000002856
drd2l
dopamine receptor D2 like
chr13_+_36958086 0.26 ENSDART00000024386
frmd6
FERM domain containing 6
chr7_-_55292116 0.26 ENSDART00000122603
rnf166
ring finger protein 166
chr15_+_26940569 0.25 ENSDART00000189636
ENSDART00000077172
bcas3
breast carcinoma amplified sequence 3
chr12_-_124264 0.25 ENSDART00000181551
FO818699.1

chr4_+_45274792 0.25 ENSDART00000150295
znf1138
zinc finger protein 1138
chr17_+_27434626 0.25 ENSDART00000052446
vgll2b
vestigial-like family member 2b
chr1_+_54737353 0.24 ENSDART00000130675
ENSDART00000162075
pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr22_-_20814450 0.23 ENSDART00000089076
dot1l
DOT1-like histone H3K79 methyltransferase
chr14_-_48961056 0.23 ENSDART00000124192
si:dkeyp-121d2.7
si:dkeyp-121d2.7
chr23_+_23119008 0.23 ENSDART00000132418
samd11
sterile alpha motif domain containing 11
chr7_+_17716601 0.23 ENSDART00000173792
ENSDART00000080825
rtn3
reticulon 3
chrM_+_4993 0.22 ENSDART00000093600
mt-nd2
NADH dehydrogenase 2, mitochondrial
chr24_-_1356668 0.22 ENSDART00000188935
nrp1a
neuropilin 1a
chr18_-_17485419 0.22 ENSDART00000018764
foxl1
forkhead box L1
chr9_+_8372167 0.22 ENSDART00000181945
ENSDART00000146122
si:dkey-90l23.1
si:dkey-90l23.1
chr12_-_26582607 0.22 ENSDART00000045186
slc16a5a
solute carrier family 16 (monocarboxylate transporter), member 5a
chr18_+_48576527 0.21 ENSDART00000167555
kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr2_-_3616363 0.21 ENSDART00000144699
pter
phosphotriesterase related
chr8_-_53926228 0.21 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr23_+_43668756 0.21 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr23_+_12072980 0.21 ENSDART00000141646
edn3b
endothelin 3b
chr23_-_14057191 0.20 ENSDART00000154908
adcy6a
adenylate cyclase 6a
chr18_+_41250938 0.19 ENSDART00000087566
trip12
thyroid hormone receptor interactor 12
chr23_-_27501923 0.18 ENSDART00000188394
asb8
ankyrin repeat and SOCS box containing 8
chr17_-_24879003 0.18 ENSDART00000123147
zbtb8a
zinc finger and BTB domain containing 8A
chrM_+_8894 0.18 ENSDART00000093611
mt-atp8
ATP synthase 8, mitochondrial
chr10_+_2876378 0.17 ENSDART00000192083
ccar2
cell cycle and apoptosis regulator 2
chr23_-_27152866 0.17 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr8_-_47800754 0.17 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr6_+_27090800 0.16 ENSDART00000121558
atg4b
autophagy related 4B, cysteine peptidase
chr3_-_21087959 0.15 ENSDART00000184418
nlk1
nemo-like kinase, type 1
chr5_+_20693724 0.15 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr17_-_8562586 0.15 ENSDART00000154257
ENSDART00000157308
fzd3b
frizzled class receptor 3b
chr17_+_5846202 0.15 ENSDART00000189713
fndc4b
fibronectin type III domain containing 4b
chr8_-_14239023 0.15 ENSDART00000090371
sin3b
SIN3 transcription regulator family member B
chr25_+_27744293 0.14 ENSDART00000103519
ENSDART00000149456
wasla
Wiskott-Aldrich syndrome-like a
chr19_+_5146460 0.14 ENSDART00000150740
si:dkey-89b17.4
si:dkey-89b17.4
chr13_+_31583034 0.14 ENSDART00000111763
six6a
SIX homeobox 6a
chr5_+_38654215 0.13 ENSDART00000144473
si:dkey-58f10.14
si:dkey-58f10.14
chr22_-_24880824 0.13 ENSDART00000061165
vtg2
vitellogenin 2
chr3_+_18846488 0.12 ENSDART00000148133
tmem104
transmembrane protein 104
chr13_-_32577386 0.12 ENSDART00000016535
kcns3a
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3a
chr2_-_21170517 0.12 ENSDART00000135417
bmi1b
bmi1 polycomb ring finger oncogene 1b
chr20_+_27194833 0.12 ENSDART00000150072
si:dkey-85n7.8
si:dkey-85n7.8
chr12_+_27096835 0.12 ENSDART00000149475
ttll6
tubulin tyrosine ligase-like family, member 6
chr8_+_45294767 0.12 ENSDART00000191527
ubap2b
ubiquitin associated protein 2b
chr5_+_36439405 0.11 ENSDART00000102973
eda
ectodysplasin A
chr20_-_28642061 0.11 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr22_-_38459316 0.11 ENSDART00000149683
ENSDART00000098461
ptk7a
protein tyrosine kinase 7a
chr22_-_7809904 0.11 ENSDART00000182269
ENSDART00000097201
ENSDART00000138522
si:ch73-44m9.3
si:ch73-44m9.1
si:ch73-44m9.3
si:ch73-44m9.1
chr15_-_24178893 0.11 ENSDART00000077980
pipox
pipecolic acid oxidase
chr2_+_35615547 0.09 ENSDART00000135843
ankrd45
ankyrin repeat domain 45
chr6_+_10094061 0.09 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr10_+_43188678 0.09 ENSDART00000012522
vcanb
versican b
chr16_+_48729947 0.08 ENSDART00000049051
brd2b
bromodomain containing 2b
chr18_+_3530769 0.08 ENSDART00000163469
si:ch73-338a16.3
si:ch73-338a16.3
chr20_-_21910043 0.07 ENSDART00000152290
ENSDART00000109084
daam1b
dishevelled associated activator of morphogenesis 1b
chr5_-_25621386 0.07 ENSDART00000051565
cyp1d1
cytochrome P450, family 1, subfamily D, polypeptide 1
chr23_+_2542158 0.06 ENSDART00000182197
LO017835.1

chr3_-_3372259 0.06 ENSDART00000140482
si:dkey-46g23.1
si:dkey-46g23.1
chr4_+_57881965 0.05 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr20_+_54349333 0.05 ENSDART00000132168
ENSDART00000147542
znf410
zinc finger protein 410
chr4_-_52165969 0.05 ENSDART00000171130
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr23_+_21978816 0.05 ENSDART00000087110
eif4g3b
eukaryotic translation initiation factor 4 gamma, 3b
chr19_+_43504480 0.05 ENSDART00000159421
BX649384.3

Network of associatons between targets according to the STRING database.

First level regulatory network of zic2a+zic2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0070983 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.3 1.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.3 2.2 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.3 1.1 GO:0033363 secretory granule organization(GO:0033363) platelet dense granule organization(GO:0060155)
0.2 0.6 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 0.8 GO:0090299 regulation of neural crest formation(GO:0090299)
0.2 0.7 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.2 1.3 GO:0090594 inflammatory response to wounding(GO:0090594)
0.1 0.6 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.1 1.3 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.5 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.9 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.4 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.1 0.3 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 3.3 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 1.4 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 1.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.5 GO:0042311 vasodilation(GO:0042311)
0.1 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.6 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 0.4 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 0.2 GO:0042373 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.1 0.2 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.6 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.8 GO:0001964 startle response(GO:0001964)
0.1 0.7 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 1.1 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.1 0.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.6 GO:0098900 regulation of action potential(GO:0098900)
0.1 1.0 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.1 0.2 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.1 1.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 0.2 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.3 GO:0034650 cortisol metabolic process(GO:0034650)
0.0 0.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.4 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0002164 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.0 1.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.4 GO:0061615 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.5 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 4.0 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 0.3 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.0 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 1.4 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 0.2 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0070977 ossification involved in bone maturation(GO:0043931) bone maturation(GO:0070977)
0.0 0.6 GO:0014823 response to activity(GO:0014823)
0.0 1.1 GO:0048854 brain morphogenesis(GO:0048854)
0.0 3.5 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0046440 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.6 GO:0006825 copper ion transport(GO:0006825)
0.0 0.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.9 GO:0032355 response to estradiol(GO:0032355)
0.0 1.8 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.6 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.4 GO:0032438 melanosome organization(GO:0032438)
0.0 1.0 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.4 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.5 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.1 GO:0090660 cerebrospinal fluid circulation(GO:0090660) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.6 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.6 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.2 GO:0002574 thrombocyte differentiation(GO:0002574)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 1.1 GO:0070062 extracellular exosome(GO:0070062)
0.2 0.7 GO:0044609 DBIRD complex(GO:0044609)
0.1 1.2 GO:0016586 RSC complex(GO:0016586)
0.1 1.3 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.8 GO:0043204 perikaryon(GO:0043204)
0.1 1.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.5 GO:0061617 MICOS complex(GO:0061617)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.5 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.4 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 2.3 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 6.2 GO:0030424 axon(GO:0030424)
0.0 0.9 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.7 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.4 2.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 0.7 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 1.6 GO:0008515 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 0.5 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.2 1.1 GO:0045735 nutrient reservoir activity(GO:0045735)
0.2 0.9 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 0.5 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.5 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.6 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.1 0.8 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.5 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.6 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 0.4 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 0.4 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 1.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.5 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.1 1.3 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 1.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 1.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.2 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.1 0.8 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.1 0.4 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.1 0.8 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 2.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.8 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 1.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 1.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.4 GO:0070095 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.0 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.1 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.3 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 0.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.1 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.3 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 2.8 GO:0042802 identical protein binding(GO:0042802)
0.0 0.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.6 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 0.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 1.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 2.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 3.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 1.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane