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PRJNA207719: Tissue specific transcriptome profiling

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Results for zic4+zic6

Z-value: 0.69

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Transcription factors associated with zic4+zic6

Gene Symbol Gene ID Gene Info
zic4
ENSDARG00000031307 zic family member 4
zic6
ENSDARG00000071496 zic family member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic6dr11_v1_chr14_+_32022272_320222720.968.3e-03Click!
zic4dr11_v1_chr24_+_4978055_49780550.941.7e-02Click!

Activity profile of zic4+zic6 motif

Sorted Z-values of zic4+zic6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_17067364 0.82 ENSDART00000132687
rab3c
RAB3C, member RAS oncogene family
chr24_-_21587335 0.70 ENSDART00000091528
gpr12
G protein-coupled receptor 12
chr21_+_3093419 0.69 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr5_+_36611128 0.63 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr12_-_41619257 0.62 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr19_-_20113696 0.61 ENSDART00000188813
npy
neuropeptide Y
chr8_-_4618653 0.56 ENSDART00000025535
sept5a
septin 5a
chr13_+_16521898 0.56 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr16_-_37964325 0.55 ENSDART00000148801
mrap2a
melanocortin 2 receptor accessory protein 2a
chr24_-_21172122 0.52 ENSDART00000154259
atp6v1ab
ATPase H+ transporting V1 subunit Ab
chr20_-_28768109 0.52 ENSDART00000114611
ENSDART00000182443
sipa1l1
signal-induced proliferation-associated 1 like 1
chr10_+_10677697 0.50 ENSDART00000188705
fam163b
family with sequence similarity 163, member B
chr16_-_55028740 0.49 ENSDART00000156368
ENSDART00000161704
zgc:114181
zgc:114181
chr5_-_10768258 0.48 ENSDART00000157043
rtn4r
reticulon 4 receptor
chr3_-_19091024 0.48 ENSDART00000188485
ENSDART00000110554
grin2ca
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr8_-_33114202 0.47 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr6_+_10450000 0.47 ENSDART00000151288
ENSDART00000187431
ENSDART00000192474
ENSDART00000188214
ENSDART00000184766
ENSDART00000190082
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr13_+_12739283 0.47 ENSDART00000102279
lingo2b
leucine rich repeat and Ig domain containing 2b
chr3_+_46724528 0.46 ENSDART00000181358
pde4a
phosphodiesterase 4A, cAMP-specific
chr22_-_18116635 0.43 ENSDART00000005724
ncanb
neurocan b
chr7_+_30787903 0.43 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr15_-_26844591 0.42 ENSDART00000077582
pitpnm3
PITPNM family member 3
chr8_+_26859639 0.38 ENSDART00000133440
prdm2a
PR domain containing 2, with ZNF domain a
chr14_-_32503363 0.38 ENSDART00000034883
mcf2a
MCF.2 cell line derived transforming sequence a
chr23_+_44741500 0.38 ENSDART00000166421
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr22_+_4707663 0.36 ENSDART00000042194
cers4a
ceramide synthase 4a
chr20_+_40769265 0.35 ENSDART00000061168
tbc1d32
TBC1 domain family, member 32
chr10_+_21786656 0.33 ENSDART00000185851
ENSDART00000167219
pcdh1g26
protocadherin 1 gamma 26
chr11_-_21586157 0.33 ENSDART00000190095
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr3_-_25814097 0.32 ENSDART00000169706
ntn1b
netrin 1b
chr17_-_4245311 0.31 ENSDART00000055379
gdf3
growth differentiation factor 3
chr24_-_20599781 0.30 ENSDART00000179664
ENSDART00000141823
zbtb47b
zinc finger and BTB domain containing 47b
chr7_-_67842997 0.26 ENSDART00000169763
pmfbp1
polyamine modulated factor 1 binding protein 1
chr13_+_32740509 0.25 ENSDART00000076423
ENSDART00000160138
sobpa
sine oculis binding protein homolog (Drosophila) a
chr7_+_27220655 0.24 ENSDART00000173987
ENSDART00000173583
plekha7b
pleckstrin homology domain containing, family A member 7b
chr20_-_14781904 0.23 ENSDART00000187200
ENSDART00000179912
ENSDART00000160481
ENSDART00000026969
suco
SUN domain containing ossification factor
chr25_+_2776511 0.23 ENSDART00000115280
neo1b
neogenin 1b
chr8_+_40210398 0.23 ENSDART00000167612
rnf34a
ring finger protein 34a
chr24_-_13566015 0.23 ENSDART00000123450
KCNB2
si:dkey-192j17.1
chr24_+_40473032 0.22 ENSDART00000084238
ENSDART00000178508
CABZ01076968.1

chr21_-_21465111 0.22 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr13_+_13821054 0.22 ENSDART00000127417
slc4a11
solute carrier family 4, sodium borate transporter, member 11
chr25_-_1079417 0.22 ENSDART00000163134
FO907089.1

chr21_-_14664445 0.21 ENSDART00000124223
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr14_+_790166 0.21 ENSDART00000123912
adra2da
adrenergic, alpha-2D-, receptor a
chr13_-_36534380 0.21 ENSDART00000177857
ENSDART00000181046
ENSDART00000187243
srsf5a
serine/arginine-rich splicing factor 5a
chr11_-_44999858 0.21 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr6_+_103361 0.20 ENSDART00000151899
ldlrb
low density lipoprotein receptor b
chr25_-_1124851 0.19 ENSDART00000067558
spg11
spastic paraplegia 11
chr5_+_13521081 0.19 ENSDART00000171975
si:ch211-230g14.6
si:ch211-230g14.6
chr19_-_82504 0.18 ENSDART00000027864
ENSDART00000160560
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr20_-_28642061 0.18 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr9_-_37748513 0.18 ENSDART00000188967
ENSDART00000187886
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr8_+_15269423 0.18 ENSDART00000020386
gclm
glutamate-cysteine ligase, modifier subunit
chr15_+_36941490 0.17 ENSDART00000172664
kirrel3l
kirre like nephrin family adhesion molecule 3, like
chr17_-_4245902 0.16 ENSDART00000151851
gdf3
growth differentiation factor 3
chr19_-_17996336 0.16 ENSDART00000186143
ENSDART00000080751
ints8
integrator complex subunit 8
chr11_+_21586335 0.16 ENSDART00000091182
FAM72B
zgc:101564
chr11_-_22605981 0.15 ENSDART00000186923
myog
myogenin
chr1_-_46401385 0.15 ENSDART00000150029
atp11a
ATPase phospholipid transporting 11A
chr3_-_19899914 0.14 ENSDART00000134969
rnd2
Rho family GTPase 2
chr19_+_40122160 0.13 ENSDART00000143966
si:ch211-173p18.3
si:ch211-173p18.3
chr19_-_17996162 0.13 ENSDART00000150928
ENSDART00000104491
ints8
integrator complex subunit 8
chr14_+_40852497 0.13 ENSDART00000128588
ENSDART00000166065
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_-_61588998 0.13 ENSDART00000050912
pex12
peroxisomal biogenesis factor 12
chr15_-_33495048 0.13 ENSDART00000159882
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr17_-_23895026 0.11 ENSDART00000122108
pdzd8
PDZ domain containing 8
chr2_-_58919975 0.11 ENSDART00000114286
sugp1
SURP and G patch domain containing 1
chr11_-_6070192 0.10 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr14_-_21097574 0.09 ENSDART00000186803
rnf20
ring finger protein 20, E3 ubiquitin protein ligase
chr1_-_58601636 0.09 ENSDART00000141143
si:ch73-236c18.8
si:ch73-236c18.8
chr2_+_25019387 0.09 ENSDART00000142601
stag1a
stromal antigen 1a
chr8_-_29822527 0.08 ENSDART00000167487
slc20a2
solute carrier family 20 (phosphate transporter), member 2
chr5_-_68927728 0.08 ENSDART00000132838
ank1a
ankyrin 1, erythrocytic a
chr17_+_52300018 0.08 ENSDART00000190302
esrrb
estrogen-related receptor beta
chr23_+_31933583 0.08 ENSDART00000145639
si:dkey-126g1.9
si:dkey-126g1.9
chr23_-_18982499 0.07 ENSDART00000012507
bcl2l1
bcl2-like 1
chr17_-_14523722 0.07 ENSDART00000024726
daam1a
dishevelled associated activator of morphogenesis 1a
chr5_+_20693724 0.07 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr19_-_81851 0.07 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr11_+_31558006 0.06 ENSDART00000024296
egln1b
egl-9 family hypoxia-inducible factor 1b
chr1_-_17711636 0.06 ENSDART00000148322
ENSDART00000122670
ufsp2
ufm1-specific peptidase 2
chr17_+_1499238 0.06 ENSDART00000187561
LO018430.1

chr3_-_37588855 0.06 ENSDART00000149258
arf2a
ADP-ribosylation factor 2a
chr11_+_34921492 0.05 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr5_-_67750907 0.05 ENSDART00000172097
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr6_+_23026714 0.04 ENSDART00000124948
srp68
signal recognition particle 68
chr18_+_49225552 0.04 ENSDART00000135026
si:ch211-136a13.1
si:ch211-136a13.1
chr3_+_24094581 0.04 ENSDART00000138270
ENSDART00000131509
copz2
coatomer protein complex, subunit zeta 2
chr10_-_4961923 0.04 ENSDART00000050177
ENSDART00000146066
snx30
sorting nexin family member 30
chr25_-_3087556 0.03 ENSDART00000193249
best1
bestrophin 1
chr10_+_26973063 0.03 ENSDART00000143162
ENSDART00000186210
tm7sf2
transmembrane 7 superfamily member 2
chr21_-_33995213 0.03 ENSDART00000140184
EBF1 (1 of many)
si:ch211-51e8.2
chr6_-_59942335 0.03 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr1_-_17711361 0.02 ENSDART00000078848
ufsp2
ufm1-specific peptidase 2
chr19_+_35799384 0.02 ENSDART00000076023
angpt2b
angiopoietin 2b
chr18_+_31117136 0.01 ENSDART00000138403
tcf25
transcription factor 25 (basic helix-loop-helix)
chr23_-_27547931 0.01 ENSDART00000144419
larp4aa
La ribonucleoprotein domain family, member 4Aa
chr23_+_9353552 0.01 ENSDART00000163298
BX511246.1

chr8_-_1266181 0.00 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr11_+_31558207 0.00 ENSDART00000140204
egln1b
egl-9 family hypoxia-inducible factor 1b
chr15_+_47746176 0.00 ENSDART00000154481
ENSDART00000160914
stard10
StAR-related lipid transfer (START) domain containing 10
chr21_-_32289356 0.00 ENSDART00000183050
clk4b
CDC-like kinase 4b

Network of associatons between targets according to the STRING database.

First level regulatory network of zic4+zic6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.3 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.1 0.5 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.3 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.1 0.6 GO:0097009 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.0 0.6 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.6 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.2 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.4 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.5 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.5 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.2 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.4 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0 0.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.1 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)
0.0 0.6 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.6 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.1 0.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0008832 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes