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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec
Z-value: 2.07
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Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000055116.9 | Arntl | |
| ENSMUSG00000000134.18 | Tfe3 | |
| ENSMUSG00000017801.16 | Mlx | |
| ENSMUSG00000035158.16 | Mitf | |
| ENSMUSG00000005373.14 | Mlxipl | |
| ENSMUSG00000029553.11 | Tfec |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mitf | mm39_v1_chr6_+_97783975_97784028 | -0.70 | 8.9e-12 | Click! |
| Arntl | mm39_v1_chr7_+_112806672_112806803 | -0.55 | 6.4e-07 | Click! |
| Mlxipl | mm39_v1_chr5_+_135135735_135135772 | 0.48 | 2.4e-05 | Click! |
| Tfe3 | mm39_v1_chrX_+_7628891_7628934 | -0.30 | 1.1e-02 | Click! |
| Tfec | mm39_v1_chr6_-_16898440_16898475 | 0.20 | 9.4e-02 | Click! |
| Mlx | mm39_v1_chr11_+_100978103_100978149 | -0.10 | 3.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.8 | 67.3 | GO:0009744 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 7.7 | 53.7 | GO:0010288 | response to lead ion(GO:0010288) |
| 13.3 | 53.3 | GO:0010269 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) response to selenium ion(GO:0010269) |
| 4.8 | 47.7 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 1.6 | 45.0 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.8 | 40.3 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 13.2 | 39.7 | GO:0002414 | immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 4.6 | 36.9 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.2 | 35.9 | GO:0007286 | spermatid development(GO:0007286) |
| 5.9 | 35.3 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 174.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.4 | 107.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 91.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 78.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 6.7 | 53.7 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 6.6 | 53.1 | GO:0097413 | Lewy body(GO:0097413) |
| 0.0 | 53.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.5 | 51.1 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 3.1 | 46.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.2 | 43.6 | GO:0043296 | apical junction complex(GO:0043296) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 22.4 | 67.3 | GO:0004454 | ketohexokinase activity(GO:0004454) |
| 0.4 | 63.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.8 | 61.1 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 1.1 | 59.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.7 | 57.7 | GO:0051287 | NAD binding(GO:0051287) |
| 1.1 | 57.5 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 45.7 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.1 | 44.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 43.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 38.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 72.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 61.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 3.0 | 56.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 38.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 28.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 24.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 20.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.6 | 20.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.7 | 16.0 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 15.7 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 69.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 58.3 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 1.4 | 56.8 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 55.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.8 | 52.7 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 1.7 | 48.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 1.7 | 43.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 2.9 | 42.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.6 | 41.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.7 | 39.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |