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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Atf1_Creb5
Z-value: 1.52
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Transcription factors associated with Atf1_Creb5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb5 | mm39_v1_chr6_+_53550285_53550334 | -0.59 | 5.0e-08 | Click! |
| Atf1 | mm39_v1_chr15_+_100126107_100126163 | 0.44 | 1.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Atf1_Creb5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_128154709 Show fit | 22.57 |
ENSMUST00000053830.5
|
high-mobility group box 4 |
|
| chr9_-_106438798 Show fit | 19.15 |
ENSMUST00010126732.2
ENSMUST00010126033.2 ENSMUST00010181659.1 ENSMUST00010126065.2 ENSMUST00010126032.3 ENSMUST00000062917.16 |
IQ motif containing F3 IQ motif containing F3 |
|
| chr17_+_33651864 Show fit | 15.90 |
ENSMUST00000174088.3
|
actin-like 9 |
|
| chr4_+_43983472 Show fit | 14.50 |
ENSMUST00000095107.3
|
calicin |
|
| chr17_-_56819422 Show fit | 14.36 |
ENSMUST00000052211.4
|
zinc and ring finger 4 |
|
| chr14_+_52155874 Show fit | 14.32 |
ENSMUST00000008957.13
|
tubulin polymerization-promoting protein family member 2 |
|
| chr4_+_56743407 Show fit | 13.46 |
ENSMUST00000095079.6
|
actin-like 7a |
|
| chr2_+_18703797 Show fit | 13.34 |
ENSMUST00000095132.10
|
sperm associated antigen 6 |
|
| chr13_-_23945189 Show fit | 13.26 |
ENSMUST00000102964.4
|
H4 clustered histone 1 |
|
| chr4_-_58009118 Show fit | 13.02 |
ENSMUST00000102897.11
ENSMUST00000239406.2 |
thioredoxin domain containing 8 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 32.9 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.3 | 30.0 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 27.4 | GO:0007286 | spermatid development(GO:0007286) |
| 0.3 | 25.3 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.1 | 22.3 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 3.3 | 19.6 | GO:0060474 | positive regulation of sperm motility involved in capacitation(GO:0060474) |
| 0.4 | 14.2 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.3 | 13.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 1.8 | 12.5 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.8 | 12.2 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 43.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 36.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.0 | 28.5 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 23.0 | GO:0005694 | chromosome(GO:0005694) |
| 0.2 | 19.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 1.3 | 17.9 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 0.1 | 15.0 | GO:0016234 | inclusion body(GO:0016234) |
| 0.1 | 13.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.7 | 13.5 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.4 | 11.9 | GO:0002080 | acrosomal membrane(GO:0002080) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 26.4 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 25.1 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 14.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 14.0 | GO:0008270 | zinc ion binding(GO:0008270) |
| 1.4 | 13.0 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.2 | 12.8 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.2 | 12.7 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.5 | 12.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 1.1 | 12.4 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 9.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 6.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 4.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 4.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 4.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 4.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.0 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 8.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 8.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.4 | 8.0 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.3 | 8.0 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 7.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.3 | 6.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 6.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 5.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 5.4 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |