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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Cbfb

Z-value: 0.62

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Transcription factors associated with Cbfb

Gene Symbol Gene ID Gene Info
Cbfb
ENSMUSG00000031885.15 Cbfb

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cbfbmm39_v1_chr8_+_105897300_105897446-0.123.3e-01Click!

Activity profile of Cbfb motif

Sorted Z-values of Cbfb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cbfb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_101967343 6.18 ENSMUST00000100337.10
Lmo7
LIM domain only 7
chr6_-_136758716 4.55 ENSMUST00000078095.11
ENSMUST00000032338.10
Gucy2c
guanylate cyclase 2c
chr17_-_35954573 4.54 ENSMUST00000095467.4
Mucl3
mucin like 3
chr2_-_58050494 4.10 ENSMUST00000028175.7
Cytip
cytohesin 1 interacting protein
chr2_+_72128239 3.15 ENSMUST00000144111.2
Map3k20
mitogen-activated protein kinase kinase kinase 20
chr2_+_125876566 2.50 ENSMUST00000064794.14
Fgf7
fibroblast growth factor 7
chrX_+_21581135 2.47 ENSMUST00000033414.8
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr1_-_174749379 2.43 ENSMUST00000055294.4
Grem2
gremlin 2, DAN family BMP antagonist
chr12_-_103304573 2.20 ENSMUST00000149431.2
Asb2
ankyrin repeat and SOCS box-containing 2
chr2_+_125876883 2.08 ENSMUST00000110442.2
Fgf7
fibroblast growth factor 7
chr16_-_92622972 1.92 ENSMUST00000023673.14
Runx1
runt related transcription factor 1
chr6_+_129385816 1.80 ENSMUST00000058352.15
ENSMUST00000088075.8
Clec9a
C-type lectin domain family 9, member a
chr15_-_101268036 1.61 ENSMUST00000077196.6
Krt80
keratin 80
chr13_-_96028412 1.59 ENSMUST00000068603.8
Iqgap2
IQ motif containing GTPase activating protein 2
chr10_+_118276949 1.57 ENSMUST00000068592.5
Ifng
interferon gamma
chr2_+_13579092 1.57 ENSMUST00000193675.2
Vim
vimentin
chr5_+_24628802 1.29 ENSMUST00000153274.2
ENSMUST00000141966.8
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chrX_+_98179725 1.26 ENSMUST00000052839.7
Efnb1
ephrin B1
chr5_+_104582978 1.18 ENSMUST00000086833.13
ENSMUST00000031243.15
ENSMUST00000112748.8
ENSMUST00000112746.8
ENSMUST00000145084.8
ENSMUST00000132457.8
Spp1
secreted phosphoprotein 1
chr6_+_129385893 1.17 ENSMUST00000204860.3
ENSMUST00000164513.8
Clec9a
C-type lectin domain family 9, member a
chr4_-_118792037 1.12 ENSMUST00000081960.5
Olfr1328
olfactory receptor 1328
chr11_-_54140462 1.09 ENSMUST00000019060.6
Csf2
colony stimulating factor 2 (granulocyte-macrophage)
chr9_-_51076724 1.07 ENSMUST00000210433.2
Gm32742
predicted gene, 32742
chr9_+_66033893 1.06 ENSMUST00000034945.6
Ciao2a
cytosolic iron-sulfur assembly component 2A
chr2_+_13578738 1.06 ENSMUST00000141365.3
ENSMUST00000028062.8
Vim
vimentin
chr15_+_99291100 0.92 ENSMUST00000159209.8
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr15_+_99290832 0.91 ENSMUST00000160635.8
ENSMUST00000161250.8
ENSMUST00000229392.2
ENSMUST00000161778.8
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr7_-_46445085 0.90 ENSMUST00000123725.2
Hps5
HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
chr3_-_151960948 0.90 ENSMUST00000199423.5
ENSMUST00000198460.5
Nexn
nexilin
chr7_-_46445305 0.87 ENSMUST00000107653.8
ENSMUST00000107654.8
ENSMUST00000014562.14
ENSMUST00000152759.8
Hps5
HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
chr2_+_164790139 0.83 ENSMUST00000017881.3
Mmp9
matrix metallopeptidase 9
chr4_+_132903646 0.78 ENSMUST00000105912.2
Wasf2
WASP family, member 2
chr14_+_65187485 0.76 ENSMUST00000043914.8
ENSMUST00000239450.2
Ints9
integrator complex subunit 9
chr1_-_140111138 0.73 ENSMUST00000111976.9
ENSMUST00000066859.13
Cfh
complement component factor h
chr17_+_12338161 0.72 ENSMUST00000024594.9
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr15_-_102112657 0.70 ENSMUST00000231030.2
ENSMUST00000230687.2
ENSMUST00000229514.2
ENSMUST00000229345.2
Csad
cysteine sulfinic acid decarboxylase
chr15_+_99291455 0.70 ENSMUST00000162624.8
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr3_-_151960992 0.67 ENSMUST00000198750.5
Nexn
nexilin
chr10_+_85763545 0.66 ENSMUST00000170396.3
Ascl4
achaete-scute family bHLH transcription factor 4
chr11_+_96680061 0.65 ENSMUST00000079702.4
Cbx1
chromobox 1
chr11_-_73217298 0.62 ENSMUST00000155630.9
Aspa
aspartoacylase
chrX_-_100777806 0.62 ENSMUST00000056614.7
Cxcr3
chemokine (C-X-C motif) receptor 3
chr16_-_16950241 0.61 ENSMUST00000023453.10
Sdf2l1
stromal cell-derived factor 2-like 1
chr4_-_118687635 0.57 ENSMUST00000076019.4
Olfr1333
olfactory receptor 1333
chr15_+_99291491 0.57 ENSMUST00000159531.3
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr3_+_14545751 0.54 ENSMUST00000037321.8
ENSMUST00000120484.8
ENSMUST00000120801.2
Slc7a12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr15_-_9529898 0.53 ENSMUST00000228782.2
ENSMUST00000003981.6
Il7r
interleukin 7 receptor
chr10_+_128769642 0.53 ENSMUST00000099112.4
ENSMUST00000218290.2
Itga7
integrin alpha 7
chr1_+_151631088 0.53 ENSMUST00000188145.7
ENSMUST00000059498.12
Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr11_+_96679976 0.50 ENSMUST00000093943.10
Cbx1
chromobox 1
chr11_-_108234743 0.49 ENSMUST00000059595.11
Prkca
protein kinase C, alpha
chr3_+_66127330 0.49 ENSMUST00000029421.6
Ptx3
pentraxin related gene
chr11_+_20581952 0.45 ENSMUST00000109586.3
Sertad2
SERTA domain containing 2
chr15_+_98687720 0.45 ENSMUST00000023734.8
Wnt1
wingless-type MMTV integration site family, member 1
chr14_+_54406112 0.43 ENSMUST00000103694.3
ENSMUST00000199452.2
Traj49
T cell receptor alpha joining 49
chr14_-_65187287 0.39 ENSMUST00000067843.10
ENSMUST00000176489.8
ENSMUST00000175905.8
ENSMUST00000022544.14
ENSMUST00000175744.8
ENSMUST00000176128.8
Hmbox1
homeobox containing 1
chr11_-_100160697 0.39 ENSMUST00000017270.8
Krt42
keratin 42
chr10_-_76276278 0.38 ENSMUST00000235907.2
ENSMUSG00000117965.2
novel protein
chr1_+_40554513 0.37 ENSMUST00000027237.12
Il18rap
interleukin 18 receptor accessory protein
chr1_+_63215976 0.34 ENSMUST00000129339.8
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr6_+_136931519 0.32 ENSMUST00000137768.2
Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr1_+_20801127 0.32 ENSMUST00000027061.5
Il17a
interleukin 17A
chr19_+_12775938 0.32 ENSMUST00000025601.8
Lpxn
leupaxin
chr2_+_154855350 0.31 ENSMUST00000148402.8
a
nonagouti
chr2_+_153780138 0.29 ENSMUST00000109757.8
ENSMUST00000154281.3
Bpifb4
BPI fold containing family B, member 4
chr9_-_48391838 0.28 ENSMUST00000216470.2
ENSMUST00000217037.2
ENSMUST00000034524.5
ENSMUST00000213895.2
Rexo2
RNA exonuclease 2
chr8_+_121262528 0.28 ENSMUST00000120493.8
Gse1
genetic suppressor element 1, coiled-coil protein
chr11_+_108812474 0.28 ENSMUST00000144511.2
Axin2
axin 2
chr7_-_115423934 0.28 ENSMUST00000169129.8
Sox6
SRY (sex determining region Y)-box 6
chr11_+_96679944 0.27 ENSMUST00000018810.10
Cbx1
chromobox 1
chr11_-_73217633 0.26 ENSMUST00000134079.2
Aspa
aspartoacylase
chr9_-_66033841 0.26 ENSMUST00000137542.2
Snx1
sorting nexin 1
chr6_-_69020489 0.22 ENSMUST00000103342.4
Igkv4-79
immunoglobulin kappa variable 4-79
chrX_+_55958781 0.19 ENSMUST00000168724.2
Adgrg4
adhesion G protein-coupled receptor G4
chr5_-_140368482 0.18 ENSMUST00000196566.5
Snx8
sorting nexin 8
chr6_-_69037208 0.08 ENSMUST00000103343.4
Igkv4-78
immunoglobulin kappa variable 4-78
chr6_+_126830050 0.08 ENSMUST00000095440.9
Akap3
A kinase (PRKA) anchor protein 3
chr2_+_35022178 0.08 ENSMUST00000113034.8
ENSMUST00000113037.10
ENSMUST00000150807.6
ENSMUST00000113033.6
Cntrl
centriolin
chr16_-_92622659 0.01 ENSMUST00000186296.2
Runx1
runt related transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.8 2.4 GO:0060300 regulation of cytokine activity(GO:0060300)
0.6 3.1 GO:0031437 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.5 1.6 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.5 1.9 GO:2000872 regulation of hair follicle cell proliferation(GO:0071336) positive regulation of progesterone secretion(GO:2000872)
0.4 1.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863)
0.3 2.6 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.3 1.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 0.8 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 0.5 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1 0.4 GO:0060061 Spemann organizer formation(GO:0060061) positive regulation of dermatome development(GO:0061184) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.1 0.7 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 0.9 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.5 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.5 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 0.7 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.3 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.1 1.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 3.8 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 3.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.6 GO:1900118 negative regulation of execution phase of apoptosis(GO:1900118)
0.0 0.3 GO:2000054 regulation of mismatch repair(GO:0032423) regulation of chondrocyte development(GO:0061181) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.7 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 1.3 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.6 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 1.0 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.0 0.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 2.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.8 GO:0043473 pigmentation(GO:0043473)
0.0 3.0 GO:0006865 amino acid transport(GO:0006865)
0.0 1.3 GO:0051453 regulation of intracellular pH(GO:0051453)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0031084 BLOC-2 complex(GO:0031084)
0.3 2.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 2.6 GO:0045098 type III intermediate filament(GO:0045098)
0.2 0.5 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.2 4.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.4 GO:0001940 male pronucleus(GO:0001940)
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.0 6.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.6 GO:0031941 filamentous actin(GO:0031941)
0.0 2.5 GO:0031526 brush border membrane(GO:0031526)
0.0 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.9 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.5 3.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.5 2.5 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.4 2.6 GO:1990254 keratin filament binding(GO:1990254)
0.3 0.9 GO:0019807 aspartoacylase activity(GO:0019807)
0.2 2.4 GO:0036122 BMP binding(GO:0036122)
0.2 4.6 GO:0015643 toxic substance binding(GO:0015643)
0.2 0.5 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 1.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.7 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.7 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 3.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.6 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 6.2 GO:0042805 actinin binding(GO:0042805)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.8 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.8 GO:0005125 cytokine activity(GO:0005125)
0.0 0.3 GO:0030553 cGMP binding(GO:0030553)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 2.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.6 PID AURORA B PATHWAY Aurora B signaling
0.0 1.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 3.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 4.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.5 ST ADRENERGIC Adrenergic Pathway
0.0 0.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.1 2.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions