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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Cdc5l

Z-value: 0.85

Motif logo

Transcription factors associated with Cdc5l

Gene Symbol Gene ID Gene Info
ENSMUSG00000023932.10 Cdc5l

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdc5lmm39_v1_chr17_-_45744637_457446710.235.2e-02Click!

Activity profile of Cdc5l motif

Sorted Z-values of Cdc5l motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdc5l

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_-_112016966 11.31 ENSMUST00000178410.2
ENSMUST00000172380.10
cyclic AMP-regulated phosphoprotein, 21
chr18_-_22983794 10.05 ENSMUST00000092015.11
ENSMUST00000069215.13
nucleolar protein 4
chr11_+_97732108 9.09 ENSMUST00000155954.3
ENSMUST00000164364.2
ENSMUST00000170806.2
RIKEN cDNA B230217C12 gene
chrX_+_135723531 8.54 ENSMUST00000113085.2
proteolipid protein (myelin) 1
chrX_+_135723420 8.29 ENSMUST00000033800.13
proteolipid protein (myelin) 1
chr4_-_149211145 7.92 ENSMUST00000030815.3
cortistatin
chr9_-_112016834 7.92 ENSMUST00000111872.9
ENSMUST00000164754.9
cyclic AMP-regulated phosphoprotein, 21
chr2_+_65451100 7.00 ENSMUST00000144254.6
ENSMUST00000028377.14
sodium channel, voltage-gated, type II, alpha
chr5_+_107645626 6.62 ENSMUST00000152474.8
ENSMUST00000060553.8
BTB (POZ) domain containing 8
chr19_+_23881821 6.10 ENSMUST00000237688.2
amyloid beta (A4) precursor protein binding, family A, member 1
chr12_+_29584560 5.65 ENSMUST00000021009.10
myelin transcription factor 1-like
chr14_+_66872699 4.90 ENSMUST00000159365.8
ENSMUST00000054661.8
ENSMUST00000225182.2
ENSMUST00000159068.2
adrenergic receptor, alpha 1a
chr4_-_119240885 4.65 ENSMUST00000238422.2
ENSMUST00000238719.2
ENSMUST00000238723.2
ENSMUST00000044781.9
ENSMUST00000084307.5
ENSMUST00000148236.9
ENSMUST00000127474.3
ENSMUST00000238704.2
coiled-coil domain containing 30
chr2_+_106525938 3.93 ENSMUST00000016530.14
metallophosphoesterase domain containing 2
chr1_-_28819331 3.82 ENSMUST00000059937.5
predicted gene 597
chr5_-_136911969 3.79 ENSMUST00000057497.13
ENSMUST00000111103.2
collagen, type XXVI, alpha 1
chr1_+_143516402 3.33 ENSMUST00000038252.4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_+_58645189 3.17 ENSMUST00000102755.4
ENSMUST00000230627.2
ENSMUST00000229923.2
uridine phosphorylase 2
chr12_+_29578354 3.07 ENSMUST00000218583.2
ENSMUST00000049784.17
myelin transcription factor 1-like
chr1_+_179938904 3.01 ENSMUST00000145181.2
CDC42 binding protein kinase alpha
chr14_-_55204054 2.89 ENSMUST00000226297.2
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr5_+_20433169 2.87 ENSMUST00000197553.5
ENSMUST00000208219.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_-_55204092 2.80 ENSMUST00000081857.14
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr5_+_67125759 2.68 ENSMUST00000238993.2
ENSMUST00000038188.14
LIM and calponin homology domains 1
chr4_-_119241024 2.63 ENSMUST00000127149.8
ENSMUST00000152879.9
ENSMUST00000238673.2
ENSMUST00000238485.2
coiled-coil domain containing 30
chr17_+_47451868 2.41 ENSMUST00000190080.9
transcriptional regulating factor 1
chr1_+_180158035 2.30 ENSMUST00000070181.7
inositol 1,4,5-trisphosphate 3-kinase B
chr7_+_51537645 2.11 ENSMUST00000208711.2
growth arrest specific 2
chr15_-_103123711 2.01 ENSMUST00000122182.2
ENSMUST00000108813.10
ENSMUST00000127191.2
chromobox 5
chrX_-_50031587 1.94 ENSMUST00000060650.7
FERM domain containing 7
chr14_-_55204383 1.68 ENSMUST00000111456.2
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr4_-_119241002 1.47 ENSMUST00000238721.2
coiled-coil domain containing 30
chr15_-_13173736 1.46 ENSMUST00000036439.6
cadherin 6
chr3_-_151899470 1.44 ENSMUST00000050073.13
DnaJ heat shock protein family (Hsp40) member B4
chr14_-_55204023 1.42 ENSMUST00000124930.8
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr5_-_138278223 1.34 ENSMUST00000014089.9
ENSMUST00000161827.8
glypican 2 (cerebroglycan)
chr5_+_67125902 1.31 ENSMUST00000127184.8
LIM and calponin homology domains 1
chr11_-_78642480 1.30 ENSMUST00000059468.6
cyclin Q
chr10_-_35587888 1.22 ENSMUST00000080898.4
S-adenosylmethionine decarboxylase 2
chr16_-_50411484 1.08 ENSMUST00000062439.6
coiled-coil domain containing 54
chr7_+_5086702 1.07 ENSMUST00000208634.2
epsin 1
chr6_+_6863269 1.06 ENSMUST00000171311.8
ENSMUST00000160937.9
distal-less homeobox 6
chr8_-_49009043 0.90 ENSMUST00000110343.3
teneurin transmembrane protein 3
chr5_+_107656810 0.81 ENSMUST00000160160.6
predicted gene 42669
chr19_+_53128861 0.80 ENSMUST00000111741.10
adducin 3 (gamma)
chr2_-_64806106 0.73 ENSMUST00000156765.2
growth factor receptor bound protein 14
chr11_+_59197746 0.71 ENSMUST00000000128.10
ENSMUST00000108783.4
wingless-type MMTV integration site family, member 9A
chr9_+_19533591 0.67 ENSMUST00000215372.2
zinc finger protein 317
chr6_+_88701810 0.63 ENSMUST00000089449.5
monoglyceride lipase
chr19_+_53128901 0.60 ENSMUST00000235754.2
ENSMUST00000237301.2
ENSMUST00000238130.2
adducin 3 (gamma)
chr2_-_151586063 0.59 ENSMUST00000109869.2
proteasome (prosome, macropain) inhibitor subunit 1
chr2_+_121991181 0.47 ENSMUST00000036089.8
tripartite motif-containing 69
chr5_+_92535705 0.41 ENSMUST00000138687.2
ENSMUST00000124509.2
ADP-ribosyltransferase 3
chr17_-_78991691 0.35 ENSMUST00000145480.2
striatin, calmodulin binding protein
chr9_+_19533374 0.35 ENSMUST00000213725.2
ENSMUST00000208694.2
zinc finger protein 317
chr2_+_85600147 0.34 ENSMUST00000065626.3
olfactory receptor 1013
chr5_-_86666408 0.32 ENSMUST00000140095.2
ENSMUST00000134179.8
transmembrane protease, serine 11g
chrX_-_36368176 0.31 ENSMUST00000130324.2
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr3_-_82957104 0.29 ENSMUST00000048246.5
fibrinogen beta chain
chr2_-_62404195 0.22 ENSMUST00000174234.8
ENSMUST00000000402.16
ENSMUST00000174448.8
ENSMUST00000102732.10
fibroblast activation protein
chr2_+_85597442 0.19 ENSMUST00000216397.3
olfactory receptor 1013
chr19_+_26727111 0.18 ENSMUST00000175842.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_+_20046748 0.14 ENSMUST00000215924.2
microtubule-associated protein 7
chr14_+_52680447 0.09 ENSMUST00000205900.3
ENSMUST00000215030.2
ENSMUST00000206100.2
ENSMUST00000206718.2
olfactory receptor 1509

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.8 GO:0007522 visceral muscle development(GO:0007522)
1.6 4.9 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.8 16.8 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.6 7.0 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.4 1.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 2.3 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.4 3.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 0.7 GO:1903537 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.2 2.9 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 6.1 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 19.2 GO:0034605 cellular response to heat(GO:0034605)
0.2 7.9 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.2 8.7 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 3.0 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:0060244 regulation of collagen catabolic process(GO:0010710) negative regulation of cell proliferation involved in contact inhibition(GO:0060244) melanocyte proliferation(GO:0097325)
0.1 1.9 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.9 GO:0097264 self proteolysis(GO:0097264)
0.0 0.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 3.2 GO:0009166 nucleotide catabolic process(GO:0009166)
0.0 3.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 4.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 2.5 GO:0007219 Notch signaling pathway(GO:0007219)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.8 GO:0005859 muscle myosin complex(GO:0005859) myosin filament(GO:0032982)
0.3 3.2 GO:0045098 type III intermediate filament(GO:0045098)
0.3 7.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.2 2.9 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.0 GO:0010369 chromocenter(GO:0010369)
0.1 16.8 GO:0043209 myelin sheath(GO:0043209)
0.0 4.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 3.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 6.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.8 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
1.2 4.9 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
1.1 16.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.8 3.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.5 3.2 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.5 8.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323) cobalt ion binding(GO:0050897)
0.4 7.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.4 2.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 2.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.2 7.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 1.2 GO:0019808 polyamine binding(GO:0019808)
0.1 6.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 21.0 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.1 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 2.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 3.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.0 PID AURORA B PATHWAY Aurora B signaling
0.0 2.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 3.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 8.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 7.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 2.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6