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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Cdx2

Z-value: 1.04

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Transcription factors associated with Cdx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000029646.4 Cdx2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdx2mm39_v1_chr5_-_147244074_1472440910.671.5e-10Click!

Activity profile of Cdx2 motif

Sorted Z-values of Cdx2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdx2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr7_+_130633776 17.88 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
deleted in malignant brain tumors 1
chr17_-_31348576 15.86 ENSMUST00000024827.5
trefoil factor 3, intestinal
chr6_+_71176811 13.76 ENSMUST00000067492.8
fatty acid binding protein 1, liver
chr11_-_99328969 10.91 ENSMUST00000017743.3
keratin 20
chr16_-_48232770 10.40 ENSMUST00000212197.2
predicted gene 5485
chr3_+_57332735 9.27 ENSMUST00000029377.8
transmembrane 4 superfamily member 4
chr3_-_14843512 8.36 ENSMUST00000094365.11
carbonic anhydrase 1
chr3_+_3699205 8.26 ENSMUST00000108394.3
hepatocyte nuclear factor 4, gamma
chr9_-_65330231 8.12 ENSMUST00000065894.7
solute carrier family 51, beta subunit
chr1_-_45542442 7.04 ENSMUST00000086430.5
collagen, type V, alpha 2
chr3_-_10273628 6.62 ENSMUST00000029041.6
fatty acid binding protein 4, adipocyte
chr11_+_96085118 6.47 ENSMUST00000062709.4
homeobox B13
chrX_+_21581135 5.72 ENSMUST00000033414.8
solute carrier family 6 (neurotransmitter transporter), member 14
chrX_+_95498965 5.61 ENSMUST00000033553.14
hephaestin
chr10_+_97400990 5.56 ENSMUST00000038160.6
lumican
chr11_+_67128843 5.38 ENSMUST00000018632.11
myosin, heavy polypeptide 4, skeletal muscle
chr11_+_94102255 5.08 ENSMUST00000041589.6
transducer of ErbB-2.1
chr6_+_17491231 4.88 ENSMUST00000080469.12
met proto-oncogene
chr11_+_96214078 4.63 ENSMUST00000093944.10
homeobox B3
chr6_-_52190299 4.59 ENSMUST00000128102.4
predicted gene 28308
chr2_+_74552322 4.15 ENSMUST00000047904.4
homeobox D4
chrX_+_138585728 4.01 ENSMUST00000096313.4
TBC1 domain family, member 8B
chr7_+_140343652 3.91 ENSMUST00000026552.9
ENSMUST00000209253.2
ENSMUST00000210235.2
cytochrome P450, family 2, subfamily e, polypeptide 1
chr8_-_34333573 3.65 ENSMUST00000183062.2
RNA binding protein gene with multiple splicing
chr8_-_5155347 3.64 ENSMUST00000023835.3
solute carrier family 10, member 2
chrX_+_162923474 3.56 ENSMUST00000073973.11
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr10_+_52267702 3.53 ENSMUST00000067085.7
nephrocan
chr4_-_63965161 3.27 ENSMUST00000107377.10
tenascin C
chr3_-_92393193 3.13 ENSMUST00000054599.8
small proline-rich protein 1A
chr8_+_15107646 2.95 ENSMUST00000033842.4
myomesin 2
chr8_+_55003359 2.31 ENSMUST00000033918.4
ankyrin repeat and SOCs box-containing 5
chr5_-_135773047 2.30 ENSMUST00000153399.2
transmembrane protein 120A
chr14_+_54923655 2.19 ENSMUST00000038539.8
ENSMUST00000228027.2
RIKEN cDNA 1700123O20 gene
chr1_-_144124871 2.15 ENSMUST00000189061.7
regulator of G-protein signaling 1
chr17_-_71305003 2.15 ENSMUST00000024846.13
ENSMUST00000232766.2
myosin, light chain 12A, regulatory, non-sarcomeric
chr15_+_3300249 2.13 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
selenoprotein P
chr14_+_80237691 2.08 ENSMUST00000228749.2
ENSMUST00000088735.4
olfactomedin 4
chr4_-_9643636 2.02 ENSMUST00000108333.8
ENSMUST00000108334.8
ENSMUST00000108335.8
ENSMUST00000152526.8
ENSMUST00000103004.10
aspartate-beta-hydroxylase
chr3_+_81904229 1.92 ENSMUST00000029641.10
acid-sensing (proton-gated) ion channel family member 5
chrX_-_50294867 1.71 ENSMUST00000114876.9
muscleblind like splicing factor 3
chr1_+_139429430 1.66 ENSMUST00000027615.7
coagulation factor XIII, beta subunit
chrM_+_8603 1.64 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr16_-_43836681 1.60 ENSMUST00000036174.10
GRAM domain containing 1C
chr15_-_101441254 1.53 ENSMUST00000023720.8
keratin 84
chr4_-_109059414 1.51 ENSMUST00000160774.8
ENSMUST00000194478.6
ENSMUST00000030288.14
ENSMUST00000162787.9
oxysterol binding protein-like 9
chr17_-_71153283 1.50 ENSMUST00000156484.2
TGFB-induced factor homeobox 1
chr11_-_99501015 1.48 ENSMUST00000076478.2
predicted gene 11937
chr2_-_51039112 1.46 ENSMUST00000154545.2
ENSMUST00000017288.9
Rho family GTPase 3
chr11_-_99996452 1.44 ENSMUST00000107416.3
keratin 36
chr8_+_95113066 1.36 ENSMUST00000161576.8
ENSMUST00000034220.8
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_-_144124787 1.36 ENSMUST00000185714.2
regulator of G-protein signaling 1
chr12_-_102844537 1.08 ENSMUST00000045652.8
ENSMUST00000223554.2
BTB (POZ) domain containing 7
chr14_-_50425655 0.98 ENSMUST00000205837.3
olfactory receptor 730
chr2_-_69542805 0.97 ENSMUST00000102706.4
ENSMUST00000073152.13
FAST kinase domains 1
chr15_-_101482320 0.96 ENSMUST00000042957.6
keratin 75
chr3_+_93052089 0.94 ENSMUST00000107300.7
ENSMUST00000195515.2
cornulin
chr13_-_24118139 0.90 ENSMUST00000052776.4
H2B clustered histone 1
chr10_-_33920289 0.87 ENSMUST00000218239.2
calcium homeostasis modulator family member 4
chr9_+_95519654 0.86 ENSMUST00000015498.9
procollagen C-endopeptidase enhancer 2
chr2_+_153742294 0.86 ENSMUST00000088955.12
ENSMUST00000135501.3
BPI fold containing family B, member 6
chrX_+_162873183 0.83 ENSMUST00000015545.10
collectrin, amino acid transport regulator
chr8_-_106660470 0.81 ENSMUST00000034368.8
chymotrypsin-like
chr2_+_142920386 0.74 ENSMUST00000028902.3
otoraplin
chr18_-_79152504 0.74 ENSMUST00000025430.11
SET binding protein 1
chr1_-_37996838 0.67 ENSMUST00000027254.10
ENSMUST00000114894.2
lysozyme G-like 1
chr16_-_88609108 0.59 ENSMUST00000232664.2
predicted gene, 20741
chr11_-_99869879 0.59 ENSMUST00000105051.2
keratin associated protein 29-1
chr3_+_126391046 0.50 ENSMUST00000106401.8
calcium/calmodulin-dependent protein kinase II, delta
chr10_-_33920300 0.48 ENSMUST00000048052.7
calcium homeostasis modulator family member 4
chr14_-_4506874 0.45 ENSMUST00000224934.2
thyroid hormone receptor beta
chr3_+_126390951 0.45 ENSMUST00000171289.8
calcium/calmodulin-dependent protein kinase II, delta
chr11_-_99932373 0.43 ENSMUST00000056362.3
keratin 34
chr1_-_186437760 0.39 ENSMUST00000195201.2
transforming growth factor, beta 2
chr15_-_50746202 0.38 ENSMUST00000184885.8
transcriptional repressor GATA binding 1
chrM_+_7758 0.37 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
chr19_-_34856853 0.37 ENSMUST00000036584.13
pantothenate kinase 1
chr14_-_63221950 0.37 ENSMUST00000100493.3
defensin beta 48
chr19_+_8828132 0.33 ENSMUST00000235683.2
ENSMUST00000096257.3
LRRN4 C-terminal like
chrM_+_7779 0.31 ENSMUST00000082408.1
mitochondrially encoded ATP synthase 6
chr19_-_47680528 0.30 ENSMUST00000026045.14
ENSMUST00000086923.6
collagen, type XVII, alpha 1
chr14_-_54923517 0.29 ENSMUST00000125265.2
apoptotic chromatin condensation inducer 1
chr13_+_23765546 0.29 ENSMUST00000102968.3
H4 clustered histone 4
chr17_-_65143066 0.27 ENSMUST00000024896.4
RIKEN cDNA 4930583I09 gene
chr11_-_99884818 0.27 ENSMUST00000105049.2
keratin associated protein 17-1
chr14_+_64229914 0.27 ENSMUST00000058229.6
retinitis pigmentosa 1 homolog like 1
chr2_-_25982160 0.26 ENSMUST00000114159.9
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr13_-_22219738 0.25 ENSMUST00000091742.6
H2A clustered histone 12
chr10_+_118040729 0.25 ENSMUST00000096691.5
interleukin 22
chr14_+_54453748 0.19 ENSMUST00000103736.2
T cell receptor alpha joining 4
chr6_+_42263644 0.15 ENSMUST00000163936.8
chloride channel, voltage-sensitive 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.6 6.5 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.9 3.6 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.9 13.8 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.8 3.3 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.8 4.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.7 4.9 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.7 5.6 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.7 17.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 2.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.6 8.1 GO:0070863 positive regulation of protein glycosylation(GO:0060050) positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.4 5.1 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.3 6.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.3 10.9 GO:0045109 intermediate filament organization(GO:0045109)
0.3 1.4 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.3 2.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 2.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 1.0 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.1 8.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 3.6 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.1 5.4 GO:0014823 response to activity(GO:0014823)
0.1 5.1 GO:0006825 copper ion transport(GO:0006825)
0.1 3.9 GO:0017144 drug metabolic process(GO:0017144)
0.1 3.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 15.9 GO:0007586 digestion(GO:0007586)
0.1 0.3 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.1 0.7 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 3.1 GO:0031424 keratinization(GO:0031424)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.1 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1 0.5 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 2.9 GO:0045616 regulation of keratinocyte differentiation(GO:0045616)
0.0 1.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 4.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 3.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 2.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 8.3 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 0.7 GO:0001502 cartilage condensation(GO:0001502)
0.0 5.7 GO:0009636 response to toxic substance(GO:0009636)
0.0 4.1 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 1.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.9 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 1.0 GO:0045333 cellular respiration(GO:0045333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0005588 collagen type V trimer(GO:0005588)
1.4 17.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
1.3 13.8 GO:0045179 apical cortex(GO:0045179)
0.6 5.6 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 1.4 GO:1990037 Lewy body core(GO:1990037)
0.2 2.9 GO:0005859 muscle myosin complex(GO:0005859)
0.2 2.1 GO:0016460 myosin II complex(GO:0016460)
0.2 6.8 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.4 GO:0032982 myosin filament(GO:0032982)
0.2 2.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 5.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 3.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 2.1 GO:0042581 specific granule(GO:0042581)
0.1 3.1 GO:0045095 keratin filament(GO:0045095)
0.1 6.7 GO:0005882 intermediate filament(GO:0005882)
0.1 3.1 GO:0001533 cornified envelope(GO:0001533)
0.1 4.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 3.6 GO:0000502 proteasome complex(GO:0000502)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 13.6 GO:0030141 secretory granule(GO:0030141)
0.0 1.0 GO:0043194 axon initial segment(GO:0043194)
0.0 15.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.9 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 3.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 17.9 GO:0035375 zymogen binding(GO:0035375)
1.5 13.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.2 4.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.1 5.7 GO:0005275 amine transmembrane transporter activity(GO:0005275)
1.0 6.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.8 8.4 GO:0004064 arylesterase activity(GO:0004064)
0.7 3.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.6 3.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.5 3.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 5.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 3.3 GO:0045545 syndecan binding(GO:0045545)
0.2 1.9 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.1 7.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 2.1 GO:0008430 selenium binding(GO:0008430)
0.1 3.9 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 8.7 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.0 GO:0031432 titin binding(GO:0031432)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 6.4 GO:0005518 collagen binding(GO:0005518)
0.1 1.5 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 5.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 5.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.7 GO:0003796 lysozyme activity(GO:0003796)
0.0 4.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.0 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 2.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 3.8 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 15.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 5.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 6.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 6.6 PID AP1 PATHWAY AP-1 transcription factor network
0.1 12.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 1.0 PID IFNG PATHWAY IFN-gamma pathway
0.0 1.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.4 5.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.3 3.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 5.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 8.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 6.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 5.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 8.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 4.9 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 13.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 3.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 3.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism