ISMARA results: Cebpa

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Cebpa_Cebpg

Z-value: 1.94

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Transcription factors associated with Cebpa_Cebpg

Gene Symbol	Gene ID	Gene Info
Cebpa Ensembl NCBI MGI UniProt	ENSMUSG00000034957.11	Cebpa
Cebpg Ensembl NCBI MGI UniProt	ENSMUSG00000056216.10	Cebpg

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Cebpa	mm39_v1_chr7_+_34818709_34818728	0.63	2.2e-09	Click!
Cebpg	mm39_v1_chr7_-_34755985_34756002	0.04	7.1e-01	Click!

Activity profile of Cebpa_Cebpg motif

Sorted Z-values of Cebpa_Cebpg motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpa_Cebpg

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_22710785 Show fit	38.50	ENSMUST00000023583.7 ENSMUST00000232098.2	Ahsg Ensembl NCBI MGI UniProt Show fit	alpha-2-HS-glycoprotein
chr3_+_20011201 Show fit	33.97	ENSMUST00000091309.12 ENSMUST00000108329.8 ENSMUST00000003714.13	Cp Ensembl NCBI MGI UniProt Show fit	ceruloplasmin
chr14_+_75479727 Show fit	32.30	ENSMUST00000022576.10	Cpb2 Ensembl NCBI MGI UniProt Show fit	carboxypeptidase B2 (plasma)
chr16_+_22877000 Show fit	31.01	ENSMUST00000039492.14 ENSMUST00000023589.15 ENSMUST00000089902.8	Kng1 Ensembl NCBI MGI UniProt Show fit	kininogen 1
chr3_+_20011251 Show fit	30.35	ENSMUST00000108328.8	Cp Ensembl NCBI MGI UniProt Show fit	ceruloplasmin
chr3_+_20011405 Show fit	29.31	ENSMUST00000108325.9	Cp Ensembl NCBI MGI UniProt Show fit	ceruloplasmin
chr16_-_22847808 Show fit	25.45	ENSMUST00000115349.9	Kng2 Ensembl NCBI MGI UniProt Show fit	kininogen 2
chr16_-_22847760 Show fit	23.19	ENSMUST00000039338.13	Kng2 Ensembl NCBI MGI UniProt Show fit	kininogen 2
chr12_-_81014849 Show fit	22.52	ENSMUST00000095572.5	Slc10a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr17_-_56428968 Show fit	22.43	ENSMUST00000041357.9	Lrg1 Ensembl NCBI MGI UniProt Show fit	leucine-rich alpha-2-glycoprotein 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	98.9	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
2.5	93.6	GO:0006825	copper ion transport(GO:0006825) response to copper ion(GO:0046688)
1.1	62.7	GO:0006953	acute-phase response(GO:0006953)
1.8	60.4	GO:0035634	response to stilbenoid(GO:0035634)
1.6	53.1	GO:0015721	bile acid and bile salt transport(GO:0015721)
6.2	37.0	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
10.8	32.3	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2	30.7	GO:0046889	positive regulation of lipid biosynthetic process(GO:0046889)
0.5	22.4	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
1.3	20.1	GO:0015747	urate transport(GO:0015747)

Showing 1 to 10 of 108 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	183.5	GO:0072562	blood microparticle(GO:0072562)
1.3	90.1	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	72.0	GO:0005615	extracellular space(GO:0005615)
0.1	51.1	GO:0016323	basolateral plasma membrane(GO:0016323)
1.5	38.3	GO:0034364	high-density lipoprotein particle(GO:0034364)
2.5	37.0	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.3	35.2	GO:0005811	lipid particle(GO:0005811)
0.2	16.4	GO:0005881	cytoplasmic microtubule(GO:0005881)
3.2	15.9	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	14.8	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	120.1	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
7.8	93.6	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
5.2	42.0	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
6.4	38.5	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
1.4	37.0	GO:0051787	misfolded protein binding(GO:0051787)
1.1	32.6	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	30.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	26.7	GO:0005506	iron ion binding(GO:0005506)
0.4	23.8	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
1.2	20.1	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)

Showing 1 to 10 of 93 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	90.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.3	44.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	40.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.6	39.8	PID BMP PATHWAY	BMP receptor signaling
0.4	30.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	14.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	8.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	6.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	6.0	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.1	5.4	PID E2F PATHWAY	E2F transcription factor network

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	97.1	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
3.8	42.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
1.8	40.4	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.3	39.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.9	24.7	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4	16.8	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.6	14.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.9	13.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	8.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.4	6.8	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism

Showing 1 to 10 of 39 entries

Results for Cebpa_Cebpg

Z-value: 1.94

Motif logo

Transcription factors associated with Cebpa_Cebpg

Activity-expression correlation:

Activity profile of Cebpa_Cebpg motif

Sorted Z-values of Cebpa_Cebpg motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpa_Cebpg

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: