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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Cebpb
Z-value: 2.97
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Transcription factors associated with Cebpb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cebpb | mm39_v1_chr2_+_167530835_167530894 | 0.64 | 1.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Cebpb
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_93324624 Show fit | 42.67 |
ENSMUST00000129421.8
|
histidine ammonia lyase |
|
| chr16_+_22877000 Show fit | 39.25 |
ENSMUST00000039492.14
ENSMUST00000023589.15 ENSMUST00000089902.8 |
kininogen 1 |
|
| chr10_+_23727325 Show fit | 37.02 |
ENSMUST00000020190.8
|
vanin 3 |
|
| chr3_+_82915031 Show fit | 33.09 |
ENSMUST00000048486.13
ENSMUST00000194175.2 |
fibrinogen gamma chain |
|
| chr16_+_22710785 Show fit | 30.25 |
ENSMUST00000023583.7
ENSMUST00000232098.2 |
alpha-2-HS-glycoprotein |
|
| chr11_+_69983459 Show fit | 30.03 |
ENSMUST00000102572.8
|
asialoglycoprotein receptor 2 |
|
| chr14_+_40827108 Show fit | 28.79 |
ENSMUST00000224514.2
|
methionine adenosyltransferase I, alpha |
|
| chr3_+_82933383 Show fit | 27.99 |
ENSMUST00000029630.15
ENSMUST00000166581.4 |
fibrinogen alpha chain |
|
| chr11_+_69983479 Show fit | 26.54 |
ENSMUST00000143772.8
|
asialoglycoprotein receptor 2 |
|
| chr14_+_40827317 Show fit | 25.83 |
ENSMUST00000047286.7
|
methionine adenosyltransferase I, alpha |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 98.5 | GO:0006953 | acute-phase response(GO:0006953) |
| 26.1 | 78.2 | GO:0009087 | methionine catabolic process(GO:0009087) |
| 1.4 | 78.1 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.5 | 72.6 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 11.9 | 59.4 | GO:0048807 | female genitalia morphogenesis(GO:0048807) |
| 1.5 | 53.8 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.4 | 44.0 | GO:0046889 | positive regulation of lipid biosynthetic process(GO:0046889) |
| 8.5 | 42.7 | GO:0006548 | histidine catabolic process(GO:0006548) |
| 1.3 | 41.3 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 5.1 | 41.2 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 406.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 204.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 74.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 7.2 | 64.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 51.9 | GO:0005811 | lipid particle(GO:0005811) |
| 1.2 | 48.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 41.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 36.1 | GO:0005576 | extracellular region(GO:0005576) |
| 3.3 | 35.9 | GO:0097433 | dense body(GO:0097433) |
| 2.1 | 35.9 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 111.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.6 | 101.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 82.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 19.6 | 78.2 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
| 0.2 | 70.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 19.8 | 59.4 | GO:0034632 | retinol transporter activity(GO:0034632) |
| 0.2 | 44.2 | GO:0005506 | iron ion binding(GO:0005506) |
| 6.1 | 42.7 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 5.2 | 41.3 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 3.4 | 40.4 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 105.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.9 | 100.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.2 | 70.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.2 | 52.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 50.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 23.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.4 | 23.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 23.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 19.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 18.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 90.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.3 | 78.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 3.6 | 61.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 3.0 | 61.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 1.1 | 48.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 3.8 | 41.3 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 1.7 | 41.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 1.1 | 31.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 27.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 1.4 | 26.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |