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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Chd1_Pml
Z-value: 3.08
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Transcription factors associated with Chd1_Pml
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pml | mm39_v1_chr9_-_58156982_58157078 | -0.22 | 5.9e-02 | Click! |
| Chd1 | mm39_v1_chr17_+_15925205_15925256 | -0.01 | 9.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Chd1_Pml
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 243.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 2.4 | 110.9 | GO:0035640 | exploration behavior(GO:0035640) |
| 5.6 | 96.0 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 0.7 | 95.6 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.8 | 76.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.2 | 73.5 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
| 2.0 | 68.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.6 | 66.7 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 6.7 | 66.6 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 3.1 | 62.7 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 650.4 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.1 | 577.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.5 | 337.2 | GO:0014069 | postsynaptic density(GO:0014069) |
| 2.5 | 259.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 3.8 | 252.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 4.2 | 234.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 4.0 | 187.4 | GO:0043194 | axon initial segment(GO:0043194) |
| 1.5 | 187.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 3.4 | 171.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 1.7 | 139.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 199.4 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 1.6 | 116.6 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 1.6 | 106.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.4 | 95.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.2 | 91.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.8 | 87.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 3.3 | 85.6 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 1.2 | 81.5 | GO:0030276 | clathrin binding(GO:0030276) |
| 3.9 | 78.9 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 2.1 | 68.4 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 93.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 75.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 70.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.5 | 69.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 2.4 | 62.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.8 | 59.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 1.0 | 56.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 1.1 | 56.7 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.7 | 48.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 1.7 | 38.0 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 214.4 | REACTOME NEURONAL SYSTEM | Genes involved in Neuronal System |
| 4.0 | 209.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.9 | 113.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 2.0 | 99.6 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 2.0 | 91.4 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 2.5 | 89.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 4.2 | 88.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 4.7 | 80.2 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.5 | 68.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 2.6 | 63.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |