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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Creb3l2

Z-value: 1.27

Motif logo

Transcription factors associated with Creb3l2

Gene Symbol Gene ID Gene Info
ENSMUSG00000038648.6 Creb3l2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3l2mm39_v1_chr6_-_37419030_374191170.325.5e-03Click!

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_26417982 13.92 ENSMUST00000142410.2
ENSMUST00000120333.8
ENSMUST00000039113.14
protein disulfide isomerase associated 2
chr5_-_31102829 10.88 ENSMUST00000031051.8
cell growth regulator with EF hand domain 1
chr2_-_92201342 6.42 ENSMUST00000176810.8
ENSMUST00000090582.11
ENSMUST00000068586.13
LARGE xylosyl- and glucuronyltransferase 2
chrX_+_138464065 6.36 ENSMUST00000113027.8
ring finger protein 128
chr5_+_63969706 5.74 ENSMUST00000081747.8
ENSMUST00000196575.5
RIKEN cDNA 0610040J01 gene
chr1_+_72863641 5.46 ENSMUST00000047328.11
insulin-like growth factor binding protein 2
chr16_-_20972750 4.90 ENSMUST00000170665.3
transmembrane epididymal family member 3
chr4_+_133280680 4.82 ENSMUST00000042706.3
nuclear receptor subfamily 0, group B, member 2
chr2_-_179976458 4.75 ENSMUST00000015771.3
GATA binding protein 5
chr9_-_67739607 4.69 ENSMUST00000054500.7
C2 calcium-dependent domain containing 4A
chr10_+_128745214 4.60 ENSMUST00000220308.2
CD63 antigen
chr5_-_139799953 4.44 ENSMUST00000044002.10
transmembrane protein 184a
chr8_-_106863521 4.40 ENSMUST00000115979.9
epithelial splicing regulatory protein 2
chrX_+_8137372 3.99 ENSMUST00000127103.8
ENSMUST00000115591.8
solute carrier family 38, member 5
chr10_+_125802084 3.97 ENSMUST00000074807.8
leucine-rich repeats and immunoglobulin-like domains 3
chr5_-_115109118 3.97 ENSMUST00000031535.12
HNF1 homeobox A
chr8_-_106863423 3.96 ENSMUST00000146940.2
epithelial splicing regulatory protein 2
chr2_-_92201311 3.94 ENSMUST00000176774.8
LARGE xylosyl- and glucuronyltransferase 2
chrX_+_8137620 3.82 ENSMUST00000033512.11
solute carrier family 38, member 5
chrX_+_8137881 3.68 ENSMUST00000115590.2
solute carrier family 38, member 5
chr12_-_25147139 3.25 ENSMUST00000221761.2
inhibitor of DNA binding 2
chr2_+_160722562 3.03 ENSMUST00000109456.9
lipin 3
chr18_+_65933586 3.01 ENSMUST00000025394.14
ENSMUST00000236847.2
ENSMUST00000153193.3
SEC11 homolog C, signal peptidase complex subunit
chr19_+_46561801 3.00 ENSMUST00000026011.8
sideroflexin 2
chr6_-_22356098 2.97 ENSMUST00000165576.8
family with sequence similarity 3, member C
chr15_-_83234372 2.90 ENSMUST00000226124.2
ENSMUST00000067215.9
ADP-ribosylation factor GTPase activating protein 3
chr2_+_180367056 2.90 ENSMUST00000094218.4
solute carrier family 17, member 9
chr6_-_83294526 2.84 ENSMUST00000005810.9
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr18_+_75500600 2.82 ENSMUST00000026999.10
SMAD family member 7
chr2_-_143853122 2.76 ENSMUST00000016072.12
ENSMUST00000037875.6
ribosome binding protein 1
chr19_+_59447950 2.74 ENSMUST00000174353.2
empty spiracles homeobox 2
chr6_-_22356067 2.68 ENSMUST00000163963.8
family with sequence similarity 3, member C
chr17_-_56583715 2.61 ENSMUST00000058136.9
toll-like receptor adaptor molecule 1
chr2_+_68691778 2.58 ENSMUST00000028426.9
ceramide synthase 6
chr5_-_46014809 2.55 ENSMUST00000190036.7
ENSMUST00000189859.7
ENSMUST00000186633.3
ENSMUST00000016026.14
ENSMUST00000045586.13
ENSMUST00000238522.2
ligand dependent nuclear receptor corepressor-like
chr5_+_143389573 2.51 ENSMUST00000110731.4
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr6_-_22356175 2.49 ENSMUST00000081288.14
family with sequence similarity 3, member C
chr4_+_148675939 2.48 ENSMUST00000006611.9
spermidine synthase
chr2_-_32584132 2.41 ENSMUST00000028148.11
folylpolyglutamyl synthetase
chr6_-_8778439 2.39 ENSMUST00000115520.8
ENSMUST00000038403.12
ENSMUST00000115518.8
islet cell autoantigen 1
chr1_+_63216281 2.26 ENSMUST00000188524.2
eukaryotic translation elongation factor 1 beta 2
chr3_+_123061094 2.24 ENSMUST00000047923.12
ENSMUST00000200333.2
Sec24 related gene family, member D (S. cerevisiae)
chr3_-_63872189 2.22 ENSMUST00000029402.15
solute carrier family 33 (acetyl-CoA transporter), member 1
chr19_+_34899752 2.20 ENSMUST00000087341.7
kinesin family member 20B
chr1_+_63215976 2.18 ENSMUST00000129339.8
eukaryotic translation elongation factor 1 beta 2
chr19_+_34899778 2.18 ENSMUST00000223907.2
kinesin family member 20B
chr14_+_26359390 2.17 ENSMUST00000112318.10
ADP-ribosylation factor 4
chr11_+_20151406 2.16 ENSMUST00000020358.12
ENSMUST00000109602.8
ENSMUST00000109601.8
ENSMUST00000163483.2
RAB1A, member RAS oncogene family
chr6_-_8778106 2.16 ENSMUST00000151758.2
ENSMUST00000115519.8
ENSMUST00000153390.8
islet cell autoantigen 1
chr11_-_120534469 2.12 ENSMUST00000141254.8
ENSMUST00000170556.8
ENSMUST00000151876.8
ENSMUST00000026133.15
ENSMUST00000139706.2
pyrroline-5-carboxylate reductase 1
chr10_+_61484331 2.08 ENSMUST00000020286.7
pyrophosphatase (inorganic) 1
chr4_+_116578117 2.08 ENSMUST00000045542.13
ENSMUST00000106459.8
testis-specific kinase 2
chr14_-_56499690 2.06 ENSMUST00000015581.6
granzyme B
chr3_-_63872079 2.03 ENSMUST00000161659.8
solute carrier family 33 (acetyl-CoA transporter), member 1
chr14_-_55880980 1.99 ENSMUST00000132338.8
transmembrane 9 superfamily member 1
chr5_-_139799780 1.97 ENSMUST00000146780.3
transmembrane protein 184a
chr14_+_26359191 1.88 ENSMUST00000022429.9
ADP-ribosylation factor 4
chr4_-_119279551 1.86 ENSMUST00000106316.2
ENSMUST00000030385.13
phosphopantothenoylcysteine synthetase
chr9_+_108216466 1.80 ENSMUST00000193987.2
glutathione peroxidase 1
chr6_+_129489501 1.79 ENSMUST00000032263.7
transmembrane protein 52B
chr18_-_40352372 1.77 ENSMUST00000025364.6
Yip1 domain family, member 5
chr19_+_6135013 1.76 ENSMUST00000025704.3
cell division cycle associated 5
chr3_-_101511971 1.72 ENSMUST00000036493.8
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr2_+_164675697 1.72 ENSMUST00000143780.9
cathepsin A
chr14_-_55880708 1.70 ENSMUST00000120041.8
ENSMUST00000121937.8
ENSMUST00000133707.2
ENSMUST00000002391.15
ENSMUST00000121791.8
transmembrane 9 superfamily member 1
chr7_+_78563513 1.69 ENSMUST00000038142.15
interferon-stimulated protein
chr9_+_108216433 1.66 ENSMUST00000191997.2
glutathione peroxidase 1
chr11_-_97673203 1.66 ENSMUST00000128801.2
ENSMUST00000103146.5
ribosomal protein L23
chr2_+_68691902 1.59 ENSMUST00000176018.2
ceramide synthase 6
chr11_-_60702081 1.56 ENSMUST00000018744.15
serine hydroxymethyltransferase 1 (soluble)
chr7_+_78563964 1.54 ENSMUST00000120331.4
interferon-stimulated protein
chr14_-_55881177 1.53 ENSMUST00000138085.2
transmembrane 9 superfamily member 1
chr11_+_100960838 1.50 ENSMUST00000001802.10
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr14_-_55881257 1.48 ENSMUST00000122358.8
transmembrane 9 superfamily member 1
chr16_-_95928804 1.48 ENSMUST00000233292.2
ENSMUST00000050884.16
high mobility group nucleosomal binding domain 1
chr11_-_94544748 1.47 ENSMUST00000039949.5
essential meiotic structure-specific endonuclease 1
chr6_+_56809044 1.44 ENSMUST00000031795.8
FK506 binding protein 9
chr19_-_40576782 1.40 ENSMUST00000176939.8
aldehyde dehydrogenase 18 family, member A1
chr19_-_40576897 1.38 ENSMUST00000025979.13
aldehyde dehydrogenase 18 family, member A1
chr19_-_40576817 1.36 ENSMUST00000175932.2
ENSMUST00000176955.8
ENSMUST00000149476.3
aldehyde dehydrogenase 18 family, member A1
chrX_-_8011952 1.35 ENSMUST00000115615.9
ENSMUST00000115616.8
ENSMUST00000115621.9
RNA binding motif (RNP1, RRM) protein 3
chr12_+_17594795 1.31 ENSMUST00000171737.3
ornithine decarboxylase, structural 1
chr10_+_12966532 1.31 ENSMUST00000121646.8
ENSMUST00000121325.8
ENSMUST00000121766.8
pleiomorphic adenoma gene-like 1
chr6_+_70821481 1.30 ENSMUST00000034093.15
ENSMUST00000162950.2
eukaryotic translation initiation factor 2 alpha kinase 3
chr11_+_100306523 1.26 ENSMUST00000001595.10
ENSMUST00000107400.3
FK506 binding protein 10
chr19_+_34899811 1.26 ENSMUST00000223776.2
kinesin family member 20B
chr4_-_106657446 1.26 ENSMUST00000148688.2
acyl-CoA thioesterase 11
chr17_-_86452564 1.24 ENSMUST00000095187.4
S1 RNA binding domain 1
chr18_+_31892933 1.24 ENSMUST00000115808.4
AMME chromosomal region gene 1-like
chr11_+_109253598 1.23 ENSMUST00000106702.4
ENSMUST00000020930.14
guanine nucleotide binding protein, alpha 13
chrX_+_73372664 1.21 ENSMUST00000004326.4
plexin A3
chr15_+_84807582 1.14 ENSMUST00000165443.4
nucleoporin 50
chrX_-_8011918 1.10 ENSMUST00000115619.8
ENSMUST00000115617.10
ENSMUST00000040010.10
RNA binding motif (RNP1, RRM) protein 3
chrX_+_49930311 1.09 ENSMUST00000114887.9
serine/threonine kinase 26
chr4_-_155737841 1.08 ENSMUST00000030937.2
matrix metallopeptidase 23
chr7_-_24950145 1.07 ENSMUST00000116343.3
ENSMUST00000045847.15
Ets2 repressor factor
chr2_+_74498551 1.05 ENSMUST00000001872.5
homeobox D13
chr16_-_78173645 1.03 ENSMUST00000023570.14
BTG anti-proliferation factor 3
chr6_+_87864796 1.01 ENSMUST00000113607.10
ENSMUST00000049966.6
coatomer protein complex, subunit gamma 1
chr9_-_87137515 1.01 ENSMUST00000093802.6
centrosomal protein 162
chr15_-_34495329 1.01 ENSMUST00000022946.6
reactive intermediate imine deaminase A homolog
chr7_+_78564062 0.99 ENSMUST00000205981.2
interferon-stimulated protein
chr17_-_24382638 0.96 ENSMUST00000129523.3
ENSMUST00000138685.3
ENSMUST00000040735.12
amidohydrolase domain containing 2
chr7_+_79042052 0.92 ENSMUST00000118959.8
ENSMUST00000036865.13
Fanconi anemia, complementation group I
chr19_+_46044972 0.91 ENSMUST00000111899.8
ENSMUST00000099392.10
ENSMUST00000062322.11
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr9_-_118917275 0.90 ENSMUST00000214470.2
phospholipase C, delta 1
chr6_-_38276157 0.89 ENSMUST00000058524.3
zinc finger CCCH-type, antiviral 1-like
chr1_+_87254729 0.89 ENSMUST00000172794.8
ENSMUST00000164992.9
ENSMUST00000173173.8
GRB10 interacting GYF protein 2
chr15_+_84807640 0.83 ENSMUST00000230411.2
nucleoporin 50
chr4_-_108263873 0.82 ENSMUST00000184609.2
glutathione peroxidase 7
chr5_-_25047577 0.80 ENSMUST00000030787.9
Ras homolog enriched in brain
chr4_+_128548479 0.76 ENSMUST00000030588.13
ENSMUST00000136377.8
polyhomeotic 2
chr17_+_29251602 0.71 ENSMUST00000130216.3
serine and arginine-rich splicing factor 3
chr10_+_20024203 0.69 ENSMUST00000020173.16
microtubule-associated protein 7
chr3_+_96604415 0.68 ENSMUST00000107077.4
protein inhibitor of activated STAT 3
chr10_-_119075910 0.68 ENSMUST00000020315.13
cullin associated and neddylation disassociated 1
chr15_+_77617804 0.67 ENSMUST00000230377.2
apolipoprotein L 9b
chrX_-_37653396 0.66 ENSMUST00000016681.15
cullin 4B
chr4_-_131802606 0.66 ENSMUST00000146021.8
erythrocyte membrane protein band 4.1
chr3_-_37778470 0.64 ENSMUST00000108105.2
ENSMUST00000079755.5
ENSMUST00000099128.2
predicted gene 5148
chr3_+_96604390 0.63 ENSMUST00000162778.3
ENSMUST00000064900.16
protein inhibitor of activated STAT 3
chr7_-_126859790 0.61 ENSMUST00000035276.5
dCTP pyrophosphatase 1
chr5_+_31212110 0.58 ENSMUST00000013773.12
ENSMUST00000201838.4
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr10_+_20024724 0.57 ENSMUST00000116259.5
ENSMUST00000214231.2
microtubule-associated protein 7
chr16_-_5021843 0.57 ENSMUST00000147567.2
ENSMUST00000023911.11
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr3_+_89680867 0.55 ENSMUST00000038356.13
ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_129489551 0.54 ENSMUST00000204741.3
transmembrane protein 52B
chr6_-_13871475 0.53 ENSMUST00000139231.2
RIKEN cDNA 2610001J05 gene
chr5_+_31212165 0.52 ENSMUST00000202795.4
ENSMUST00000201182.4
ENSMUST00000200953.4
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr1_+_75119419 0.51 ENSMUST00000097694.11
ENSMUST00000190240.7
reticulophagy regulator family member 2
chr5_+_108416763 0.49 ENSMUST00000031190.5
down-regulator of transcription 1
chr16_-_4867703 0.49 ENSMUST00000115844.3
ENSMUST00000023189.15
glyoxylate reductase 1 homolog (Arabidopsis)
chr13_-_103911092 0.47 ENSMUST00000074616.7
splicing regulatory glutamine/lysine-rich protein 1
chr8_-_105981732 0.47 ENSMUST00000093217.9
ENSMUST00000161745.3
ENSMUST00000136822.3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr11_-_5049223 0.47 ENSMUST00000079949.13
Ewing sarcoma breakpoint region 1
chr9_-_107166543 0.46 ENSMUST00000192054.2
mitogen-activated protein kinase-activated protein kinase 3
chr4_+_99544536 0.46 ENSMUST00000087285.5
forkhead box D3
chr2_-_126718129 0.45 ENSMUST00000103224.10
transient receptor potential cation channel, subfamily M, member 7
chr10_+_80008768 0.41 ENSMUST00000041882.7
family with sequence similarity 174, member C
chr2_+_150628655 0.39 ENSMUST00000045441.8
brain glycogen phosphorylase
chr11_+_100436433 0.38 ENSMUST00000092684.12
ENSMUST00000006976.8
outer dynein arm complex subunit 4
chr17_-_12988492 0.38 ENSMUST00000024599.14
insulin-like growth factor 2 receptor
chr6_-_13871454 0.37 ENSMUST00000185219.2
ENSMUST00000185361.2
ENSMUST00000155856.2
RIKEN cDNA 2610001J05 gene
chr7_+_16609227 0.37 ENSMUST00000108493.3
dishevelled-binding antagonist of beta-catenin 3
chr6_-_40917431 0.35 ENSMUST00000122181.8
ENSMUST00000031935.10
RIKEN cDNA 1700074P13 gene
chr4_+_148123554 0.34 ENSMUST00000141283.8
methylenetetrahydrofolate reductase
chr15_+_34495441 0.32 ENSMUST00000052290.14
ENSMUST00000079028.6
processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
chr14_-_70588803 0.32 ENSMUST00000143153.2
ENSMUST00000127000.2
ENSMUST00000068044.14
ENSMUST00000022688.10
solute carrier family 39 (zinc transporter), member 14
chr2_-_162929732 0.32 ENSMUST00000094653.6
gametocyte specific factor 1-like
chr5_-_137608726 0.32 ENSMUST00000197912.5
procollagen C-endopeptidase enhancer protein
chr5_-_137608886 0.31 ENSMUST00000142675.8
procollagen C-endopeptidase enhancer protein
chr16_+_4867876 0.25 ENSMUST00000230703.2
ENSMUST00000052449.6
ubinuclein 1
chr13_+_90237824 0.25 ENSMUST00000012566.9
transmembrane protein 167
chr7_-_45116316 0.24 ENSMUST00000033093.10
BCL2-associated X protein
chr13_-_24390265 0.23 ENSMUST00000123076.8
capping protein regulator and myosin 1 linker 1
chr7_-_105289515 0.20 ENSMUST00000133519.8
ENSMUST00000209550.2
ENSMUST00000210911.2
ENSMUST00000084782.10
ENSMUST00000131446.8
ADP-ribosylation factor interacting protein 2
chr2_-_126718037 0.20 ENSMUST00000028843.12
transient receptor potential cation channel, subfamily M, member 7
chr15_+_79575046 0.19 ENSMUST00000046463.10
GTP binding protein 1
chr4_-_131802561 0.19 ENSMUST00000105970.8
ENSMUST00000105975.8
erythrocyte membrane protein band 4.1
chr4_+_44756608 0.18 ENSMUST00000143385.2
zinc finger, CCHC domain containing 7
chr6_-_145021816 0.17 ENSMUST00000111742.8
ENSMUST00000048252.11
branched chain aminotransferase 1, cytosolic
chr13_-_94422337 0.17 ENSMUST00000022197.15
ENSMUST00000152555.8
secretory carrier membrane protein 1
chr18_+_67597929 0.17 ENSMUST00000025411.9
PRELI domain containing 3A
chr8_-_125390107 0.15 ENSMUST00000034464.8
RIKEN cDNA 2310022B05 gene
chr19_-_6817955 0.13 ENSMUST00000239527.1
ribosomal protein S6 kinase, polypeptide 4
chr4_+_136038243 0.12 ENSMUST00000131671.8
heterogeneous nuclear ribonucleoprotein R
chr9_+_21867043 0.11 ENSMUST00000053583.7
SWIM type zinc finger 7 associated protein 1
chr8_-_95328348 0.08 ENSMUST00000212547.2
ENSMUST00000212507.2
ENSMUST00000034226.8
proteasome activator subunit 3 interacting protein 1
chr2_+_70491901 0.07 ENSMUST00000112201.8
ENSMUST00000028509.11
ENSMUST00000133432.8
ENSMUST00000112205.2
golgi reassembly stacking protein 2
chr5_+_31026967 0.05 ENSMUST00000114716.4
transmembrane protein 214
chr17_-_29566774 0.04 ENSMUST00000095427.12
ENSMUST00000118366.9
mitochondrial carrier 1
chr4_+_136038301 0.03 ENSMUST00000084219.12
heterogeneous nuclear ribonucleoprotein R
chr6_-_93769426 0.02 ENSMUST00000204788.2
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr8_-_95328260 0.02 ENSMUST00000212765.2
ENSMUST00000213008.2
ENSMUST00000212159.2
ENSMUST00000213022.2
ENSMUST00000212258.2
ENSMUST00000212788.2
ENSMUST00000212791.2
proteasome activator subunit 3 interacting protein 1
chr11_+_82671934 0.01 ENSMUST00000092849.12
ENSMUST00000021039.12
ENSMUST00000080461.12
ENSMUST00000173347.8
ENSMUST00000173727.8
ENSMUST00000173009.8
ENSMUST00000131537.9
ENSMUST00000173722.8
ligase III, DNA, ATP-dependent

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.3 4.0 GO:0032474 otolith morphogenesis(GO:0032474)
1.1 3.2 GO:0001966 thigmotaxis(GO:0001966)
1.1 6.4 GO:0018992 germ-line sex determination(GO:0018992)
0.9 5.6 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.9 3.5 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) response to selenium ion(GO:0010269)
0.9 10.4 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.8 2.4 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.8 4.6 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.7 4.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.7 2.6 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.6 11.5 GO:0015816 glycine transport(GO:0015816)
0.5 1.6 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.5 1.5 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.5 1.5 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.5 5.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.4 1.3 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.4 2.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.4 1.7 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.4 2.5 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.4 2.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4 1.2 GO:1902287 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.4 2.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.4 1.8 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3 1.7 GO:1903416 response to glycoside(GO:1903416)
0.3 1.7 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.3 13.9 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.3 4.0 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.3 2.8 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.3 1.3 GO:0033387 putrescine biosynthetic process(GO:0009446) putrescine biosynthetic process from ornithine(GO:0033387)
0.2 0.7 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 4.8 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 0.6 GO:0042262 DNA protection(GO:0042262)
0.2 0.9 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.2 1.0 GO:0060526 prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.2 8.4 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.2 5.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 6.4 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.2 3.0 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.1 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 1.0 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 1.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 4.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 2.7 GO:0021542 dentate gyrus development(GO:0021542)
0.1 1.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 2.6 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.1 0.6 GO:0070459 prolactin secretion(GO:0070459)
0.1 1.0 GO:0051683 establishment of Golgi localization(GO:0051683)
0.1 2.2 GO:0032402 melanosome transport(GO:0032402)
0.1 0.2 GO:0051695 actin filament uncapping(GO:0051695) negative regulation of barbed-end actin filament capping(GO:2000813)
0.1 1.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 4.4 GO:0006414 translational elongation(GO:0006414)
0.1 0.8 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 2.9 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 1.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 3.7 GO:0009409 response to cold(GO:0009409)
0.1 4.2 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 0.7 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 1.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 1.5 GO:0046548 retinal rod cell development(GO:0046548)
0.1 3.0 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 0.3 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 4.8 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 0.6 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.1 0.5 GO:0044351 macropinocytosis(GO:0044351)
0.0 4.2 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.9 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 1.1 GO:0036474 cell death in response to hydrogen peroxide(GO:0036474) regulation of hydrogen peroxide-induced cell death(GO:1903205)
0.0 11.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.7 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 3.0 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 0.2 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 1.4 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 2.1 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.3 GO:0071578 iron ion transport(GO:0006826) zinc II ion transmembrane import(GO:0071578)
0.0 0.4 GO:0009251 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.3 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.3 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0031904 endosome lumen(GO:0031904)
0.6 4.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 3.5 GO:0097413 Lewy body(GO:0097413)
0.4 2.1 GO:0044194 cytolytic granule(GO:0044194)
0.3 3.0 GO:0005787 signal peptidase complex(GO:0005787)
0.3 1.5 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.3 2.6 GO:0097342 ripoptosome(GO:0097342)
0.3 1.0 GO:0005879 axonemal microtubule(GO:0005879)
0.2 5.6 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 1.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 2.8 GO:0016342 catenin complex(GO:0016342)
0.1 1.8 GO:0008278 cohesin complex(GO:0008278)
0.1 4.0 GO:0045120 pronucleus(GO:0045120)
0.1 6.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.2 GO:0097144 BAX complex(GO:0097144)
0.1 1.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 4.2 GO:0015030 Cajal body(GO:0015030)
0.1 5.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 4.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 3.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 4.7 GO:0005770 late endosome(GO:0005770)
0.0 0.9 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 2.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.9 GO:0099738 cell cortex region(GO:0099738)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 21.2 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 25.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 10.6 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
1.2 13.9 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
1.2 10.4 GO:0042285 xylosyltransferase activity(GO:0042285)
0.8 4.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.8 4.2 GO:0008859 exoribonuclease II activity(GO:0008859)
0.8 11.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.8 2.4 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.6 5.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.5 1.6 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372)
0.5 2.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.5 2.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.5 2.8 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.4 2.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4 4.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 1.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 1.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3 2.8 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.3 1.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.3 2.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 1.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 0.8 GO:0004096 catalase activity(GO:0004096)
0.2 5.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 4.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 0.5 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 1.7 GO:1990239 steroid hormone binding(GO:1990239)
0.2 4.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 3.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 2.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.0 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 2.1 GO:0015929 hexosaminidase activity(GO:0015929)
0.1 0.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 3.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.4 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 1.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 5.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 4.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 0.6 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 1.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 5.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 2.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 8.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 1.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 6.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 1.0 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 10.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.5 GO:0008378 galactosyltransferase activity(GO:0008378)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 13.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 1.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.8 PID ALK1 PATHWAY ALK1 signaling events
0.1 2.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.0 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 5.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 6.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.9 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 4.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.6 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 6.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 3.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 3.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 9.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 4.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 4.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 4.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 4.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 3.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.1 1.9 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 3.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 4.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 4.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 6.1 REACTOME TRANSLATION Genes involved in Translation
0.0 1.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.7 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm