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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for E2f1
Z-value: 4.01
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Transcription factors associated with E2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f1 | mm39_v1_chr2_-_154411765_154411812 | 0.56 | 2.5e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_56610396 Show fit | 31.75 |
ENSMUST00000113038.8
|
ubiquitin-like, containing PHD and RING finger domains, 1 |
|
| chr18_+_56840813 Show fit | 29.01 |
ENSMUST00000025486.9
|
lamin B1 |
|
| chr7_+_102090892 Show fit | 28.50 |
ENSMUST00000033283.10
|
ribonucleotide reductase M1 |
|
| chr5_+_45827249 Show fit | 28.41 |
ENSMUST00000117396.3
|
non-SMC condensin I complex, subunit G |
|
| chr6_-_47571901 Show fit | 28.33 |
ENSMUST00000081721.13
ENSMUST00000114618.8 ENSMUST00000114616.8 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
|
| chr9_+_65797519 Show fit | 28.26 |
ENSMUST00000045802.7
|
PCNA clamp associated factor |
|
| chr17_+_56610321 Show fit | 25.93 |
ENSMUST00000001258.15
|
ubiquitin-like, containing PHD and RING finger domains, 1 |
|
| chr1_-_20890437 Show fit | 24.14 |
ENSMUST00000053266.11
|
minichromosome maintenance complex component 3 |
|
| chr17_+_29709723 Show fit | 23.57 |
ENSMUST00000024811.9
|
proviral integration site 1 |
|
| chr16_+_93680783 Show fit | 23.37 |
ENSMUST00000023666.11
ENSMUST00000117099.8 |
chromatin assembly factor 1, subunit B (p60) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 87.6 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 3.5 | 80.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 3.0 | 77.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 6.2 | 74.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 4.4 | 69.6 | GO:0019985 | translesion synthesis(GO:0019985) |
| 4.6 | 69.4 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 3.0 | 57.1 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 1.8 | 53.9 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 2.3 | 50.3 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 4.0 | 43.7 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 280.5 | GO:0005634 | nucleus(GO:0005634) |
| 0.3 | 236.9 | GO:0005694 | chromosome(GO:0005694) |
| 7.9 | 126.5 | GO:0042555 | MCM complex(GO:0042555) |
| 1.8 | 123.8 | GO:0005657 | replication fork(GO:0005657) |
| 0.4 | 84.5 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 10.2 | 61.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 4.7 | 56.8 | GO:0000796 | condensin complex(GO:0000796) |
| 1.6 | 50.1 | GO:0045120 | pronucleus(GO:0045120) |
| 15.1 | 45.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.4 | 42.5 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 121.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 94.9 | GO:0003677 | DNA binding(GO:0003677) |
| 0.7 | 77.8 | GO:0004386 | helicase activity(GO:0004386) |
| 2.1 | 77.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 10.9 | 76.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 10.2 | 61.4 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.5 | 54.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 53.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 5.3 | 52.6 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.8 | 44.8 | GO:0070063 | RNA polymerase binding(GO:0070063) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 223.0 | PID E2F PATHWAY | E2F transcription factor network |
| 2.8 | 147.5 | PID ATR PATHWAY | ATR signaling pathway |
| 1.7 | 97.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.3 | 63.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.9 | 45.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.6 | 44.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 1.5 | 40.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.3 | 33.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 33.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.4 | 32.8 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 142.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 7.6 | 122.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 3.7 | 114.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.4 | 61.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.7 | 54.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 3.3 | 53.5 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.7 | 52.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 50.7 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 1.8 | 48.6 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 2.4 | 47.3 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |