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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for E2f2_E2f5
Z-value: 3.86
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Transcription factors associated with E2f2_E2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm39_v1_chr4_+_135899678_135899738 | 0.92 | 3.9e-30 | Click! |
| E2f5 | mm39_v1_chr3_+_14643669_14643756 | -0.01 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f2_E2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.1 | 157.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 6.4 | 146.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 7.3 | 130.9 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 3.3 | 108.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 4.6 | 69.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 10.8 | 64.8 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 20.2 | 60.7 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 1.3 | 52.7 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 4.7 | 51.9 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 5.5 | 49.8 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.0 | 208.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 178.4 | GO:0005634 | nucleus(GO:0005634) |
| 2.2 | 144.1 | GO:0005657 | replication fork(GO:0005657) |
| 23.2 | 139.2 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 134.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 122.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.5 | 112.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.7 | 50.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 9.9 | 49.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.2 | 42.5 | GO:0005819 | spindle(GO:0005819) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 154.8 | GO:0001047 | core promoter binding(GO:0001047) |
| 23.2 | 139.2 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 2.6 | 133.7 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 12.4 | 87.0 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 4.2 | 76.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 71.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 65.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.5 | 64.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.6 | 60.4 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 11.9 | 59.4 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 286.4 | PID E2F PATHWAY | E2F transcription factor network |
| 4.1 | 202.9 | PID ATR PATHWAY | ATR signaling pathway |
| 5.1 | 92.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 7.9 | 79.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.9 | 58.9 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.9 | 50.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 34.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.1 | 31.7 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.4 | 27.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.9 | 25.0 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.1 | 309.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 15.1 | 241.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 7.3 | 101.7 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 4.4 | 74.5 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.5 | 62.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 50.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.1 | 49.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.2 | 38.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.9 | 37.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.5 | 35.4 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |