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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for E2f2_E2f5

Z-value: 3.86

Motif logo

Transcription factors associated with E2f2_E2f5

Gene Symbol Gene ID Gene Info
ENSMUSG00000018983.10 E2f2
ENSMUSG00000027552.15 E2f5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f2mm39_v1_chr4_+_135899678_1358997380.923.9e-30Click!
E2f5mm39_v1_chr3_+_14643669_14643756-0.019.1e-01Click!

Activity profile of E2f2_E2f5 motif

Sorted Z-values of E2f2_E2f5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f2_E2f5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_135899678 64.78 ENSMUST00000061721.6
E2F transcription factor 2
chr12_+_24758240 60.09 ENSMUST00000020980.12
ribonucleotide reductase M2
chr13_-_55477535 54.35 ENSMUST00000021941.8
Max dimerization protein 3
chr10_-_69188716 52.36 ENSMUST00000119827.8
ENSMUST00000020099.13
cyclin-dependent kinase 1
chr17_+_56611313 51.17 ENSMUST00000113035.8
ENSMUST00000113039.9
ENSMUST00000142387.2
ubiquitin-like, containing PHD and RING finger domains, 1
chr2_+_72306503 48.11 ENSMUST00000102691.11
ENSMUST00000157019.2
cell division cycle associated 7
chr2_-_157046386 42.91 ENSMUST00000029170.8
RB transcriptional corepressor like 1
chr8_+_75836187 42.49 ENSMUST00000164309.3
ENSMUST00000212426.2
ENSMUST00000212811.2
minichromosome maintenance complex component 5
chr12_+_24758968 38.30 ENSMUST00000154588.2
ribonucleotide reductase M2
chr9_+_122780111 38.09 ENSMUST00000040717.7
ENSMUST00000214652.2
ENSMUST00000217401.2
kinesin family member 15
chr10_-_5755412 34.62 ENSMUST00000019907.8
F-box protein 5
chr12_+_24758724 34.46 ENSMUST00000153058.8
ribonucleotide reductase M2
chr5_-_138170077 34.00 ENSMUST00000155902.8
ENSMUST00000148879.8
minichromosome maintenance complex component 7
chrX_-_50294652 32.27 ENSMUST00000114875.8
muscleblind like splicing factor 3
chr4_+_126450728 31.12 ENSMUST00000048391.15
claspin
chr10_-_21036792 30.71 ENSMUST00000188495.8
myeloblastosis oncogene
chr2_-_113678999 29.46 ENSMUST00000102545.8
ENSMUST00000110948.8
Rho GTPase activating protein 11A
chr15_-_57998443 29.45 ENSMUST00000038194.5
ATPase family, AAA domain containing 2
chr1_-_128287347 28.57 ENSMUST00000190495.2
ENSMUST00000027601.11
minichromosome maintenance complex component 6
chr10_-_21036824 28.21 ENSMUST00000020158.9
myeloblastosis oncogene
chr5_+_110434172 27.49 ENSMUST00000007296.12
ENSMUST00000112482.2
polymerase (DNA directed), epsilon
chr6_-_88875646 26.78 ENSMUST00000058011.8
minichromosome maintenance complex component 2
chr1_-_20890437 26.73 ENSMUST00000053266.11
minichromosome maintenance complex component 3
chr4_+_134591847 26.15 ENSMUST00000030627.8
Rh blood group, D antigen
chr2_-_113678945 25.93 ENSMUST00000110949.9
Rho GTPase activating protein 11A
chr6_-_47571901 25.35 ENSMUST00000081721.13
ENSMUST00000114618.8
ENSMUST00000114616.8
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr2_+_118943274 24.28 ENSMUST00000140939.8
ENSMUST00000028795.10
RAD51 recombinase
chr7_-_48530777 23.15 ENSMUST00000058745.15
E2F transcription factor 8
chr11_+_79980210 22.68 ENSMUST00000017694.7
ENSMUST00000108239.7
ATPase family, AAA domain containing 5
chr7_-_48531344 22.68 ENSMUST00000119223.2
E2F transcription factor 8
chr17_+_56610396 22.35 ENSMUST00000113038.8
ubiquitin-like, containing PHD and RING finger domains, 1
chr5_-_138170644 22.15 ENSMUST00000000505.16
minichromosome maintenance complex component 7
chr12_-_69274936 22.12 ENSMUST00000221411.2
ENSMUST00000021359.7
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr16_-_15455141 21.61 ENSMUST00000023353.4
minichromosome maintenance complex component 4
chr2_+_150751475 21.13 ENSMUST00000028948.5
GINS complex subunit 1 (Psf1 homolog)
chr2_-_113678616 20.74 ENSMUST00000110947.2
Rho GTPase activating protein 11A
chr13_-_24945844 20.51 ENSMUST00000006898.10
ENSMUST00000110382.9
geminin
chrX_-_50294867 20.47 ENSMUST00000114876.9
muscleblind like splicing factor 3
chr9_+_65797519 20.08 ENSMUST00000045802.7
PCNA clamp associated factor
chr4_+_114857348 19.16 ENSMUST00000030490.13
Scl/Tal1 interrupting locus
chr12_-_11315755 19.09 ENSMUST00000166117.4
ENSMUST00000219600.2
ENSMUST00000218487.2
GEN1, Holliday junction 5' flap endonuclease
chr4_+_134195631 18.81 ENSMUST00000030636.11
ENSMUST00000127279.8
ENSMUST00000105867.8
stathmin 1
chr14_-_20438890 18.71 ENSMUST00000022345.7
DnaJ heat shock protein family (Hsp40) member C9
chr5_+_88912855 18.44 ENSMUST00000031311.10
deoxycytidine kinase
chr13_-_24945423 17.60 ENSMUST00000176890.8
ENSMUST00000175689.8
geminin
chr9_+_64188857 17.02 ENSMUST00000215031.2
ENSMUST00000213165.2
ENSMUST00000213289.2
ENSMUST00000216594.2
ENSMUST00000034964.7
timeless interacting protein
chr9_+_44245981 16.82 ENSMUST00000052686.4
H2A.X variant histone
chr4_-_133695264 16.30 ENSMUST00000102553.11
high mobility group nucleosomal binding domain 2
chr12_+_116369017 16.22 ENSMUST00000084828.5
ENSMUST00000222469.2
ENSMUST00000221114.2
ENSMUST00000221970.2
non-SMC condensin II complex, subunit G2
chr9_+_109704609 16.20 ENSMUST00000094324.8
cell division cycle 25A
chr15_-_8473918 15.81 ENSMUST00000052965.8
NIPBL cohesin loading factor
chr6_+_51447613 15.63 ENSMUST00000114445.8
ENSMUST00000114446.8
ENSMUST00000141711.3
chromobox 3
chrX_-_92675719 15.58 ENSMUST00000006856.3
polymerase (DNA directed), alpha 1
chr1_-_191307648 15.47 ENSMUST00000027933.11
denticleless E3 ubiquitin protein ligase
chr9_-_20864096 15.29 ENSMUST00000004202.17
DNA methyltransferase (cytosine-5) 1
chr10_+_110581293 14.85 ENSMUST00000174857.8
ENSMUST00000073781.12
ENSMUST00000173471.8
ENSMUST00000173634.2
E2F transcription factor 7
chr1_-_88629843 14.78 ENSMUST00000159814.2
ADP-ribosylation factor-like 4C
chr15_-_9140403 14.77 ENSMUST00000096482.10
S-phase kinase-associated protein 2
chr2_-_154411765 14.66 ENSMUST00000103145.11
E2F transcription factor 1
chr13_-_47259652 14.37 ENSMUST00000021807.13
ENSMUST00000135278.8
DEK proto-oncogene (DNA binding)
chr17_+_29020064 14.35 ENSMUST00000004985.11
bromodomain and PHD finger containing, 3
chr7_-_125995884 14.07 ENSMUST00000075671.5
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr19_+_38919477 14.03 ENSMUST00000145051.2
helicase, lymphoid specific
chr17_+_23945310 13.74 ENSMUST00000024701.9
protein kinase, membrane associated tyrosine/threonine 1
chr3_+_97920819 13.59 ENSMUST00000079812.8
notch 2
chr17_+_56610321 13.45 ENSMUST00000001258.15
ubiquitin-like, containing PHD and RING finger domains, 1
chrX_-_7940959 13.28 ENSMUST00000115636.4
ENSMUST00000115638.10
suppressor of variegation 3-9 1
chr8_-_54091980 13.21 ENSMUST00000047768.11
nei like 3 (E. coli)
chr2_-_154411640 13.05 ENSMUST00000000894.6
E2F transcription factor 1
chr8_+_13388745 12.79 ENSMUST00000209885.2
ENSMUST00000209396.2
transcription factor Dp 1
chr2_-_169984593 12.65 ENSMUST00000109155.8
zinc finger protein 217
chr6_+_51447490 12.63 ENSMUST00000031862.14
chromobox 3
chr10_-_60055082 12.56 ENSMUST00000135158.9
carbohydrate sulfotransferase 3
chr4_+_114857370 12.56 ENSMUST00000129957.8
Scl/Tal1 interrupting locus
chr12_+_71063431 12.53 ENSMUST00000125125.2
AT rich interactive domain 4A (RBP1-like)
chr8_-_34578880 12.23 ENSMUST00000080152.5
predicted pseudogene 10131
chr14_-_73563212 12.05 ENSMUST00000022701.7
RB transcriptional corepressor 1
chr19_+_53588808 11.71 ENSMUST00000025930.10
structural maintenance of chromosomes 3
chr11_-_6394352 11.56 ENSMUST00000093346.6
H2A.Z histone variant 2
chr3_-_95125002 11.51 ENSMUST00000107209.8
GA repeat binding protein, beta 2
chr3_-_95125190 11.26 ENSMUST00000136139.8
GA repeat binding protein, beta 2
chr1_+_86454431 10.93 ENSMUST00000045897.15
ENSMUST00000186255.7
ENSMUST00000188699.7
prothymosin alpha
chr15_-_9140460 10.91 ENSMUST00000110585.10
S-phase kinase-associated protein 2
chr1_+_183766572 10.83 ENSMUST00000048655.8
dual specificity phosphatase 10
chr5_-_136596299 10.83 ENSMUST00000004097.16
cut-like homeobox 1
chrX_+_41239872 10.63 ENSMUST00000123245.8
stromal antigen 2
chr17_+_29709723 10.23 ENSMUST00000024811.9
proviral integration site 1
chr19_+_38919353 10.14 ENSMUST00000025965.12
helicase, lymphoid specific
chrX_+_49930311 9.82 ENSMUST00000114887.9
serine/threonine kinase 26
chr1_+_86454511 9.46 ENSMUST00000188533.2
prothymosin alpha
chr9_+_103182352 9.43 ENSMUST00000035164.10
topoisomerase (DNA) II binding protein 1
chr17_-_71782296 9.32 ENSMUST00000127430.2
SMC hinge domain containing 1
chr5_+_45827249 9.20 ENSMUST00000117396.3
non-SMC condensin I complex, subunit G
chr11_+_98798627 9.12 ENSMUST00000092706.13
cell division cycle 6
chr14_+_79689230 9.12 ENSMUST00000100359.3
ENSMUST00000226192.2
kelch repeat and BTB (POZ) domain containing 6
chr11_-_87295292 9.00 ENSMUST00000067692.13
RAD51 paralog C
chr18_+_56840813 8.94 ENSMUST00000025486.9
lamin B1
chr9_-_21202545 8.72 ENSMUST00000215619.2
cyclin dependent kinase inhibitor 2D
chr15_+_61857390 8.70 ENSMUST00000159327.2
ENSMUST00000167731.8
myelocytomatosis oncogene
chr6_-_148847854 8.58 ENSMUST00000139355.8
ENSMUST00000146457.2
ENSMUST00000054080.15
SIN3-HDAC complex associated factor
chr7_+_126380655 8.56 ENSMUST00000172352.8
ENSMUST00000094037.5
T-box 6
chr15_+_61857226 8.54 ENSMUST00000161976.8
ENSMUST00000022971.8
myelocytomatosis oncogene
chr13_-_22017677 8.53 ENSMUST00000081342.7
H2A clustered histone 24
chr4_+_126450762 8.42 ENSMUST00000147675.2
claspin
chr2_-_28511941 8.38 ENSMUST00000028156.8
ENSMUST00000164290.8
growth factor independent 1B
chr19_-_10181243 8.34 ENSMUST00000142241.2
ENSMUST00000116542.9
ENSMUST00000025651.6
ENSMUST00000156291.2
flap structure specific endonuclease 1
chr1_-_176641607 8.29 ENSMUST00000195717.6
ENSMUST00000192961.6
centrosomal protein 170
chr15_-_54953819 8.17 ENSMUST00000110231.2
ENSMUST00000023059.13
DNA replication and sister chromatid cohesion 1
chr3_-_127346882 8.12 ENSMUST00000197668.2
ENSMUST00000029588.10
La ribonucleoprotein domain family, member 7
chr8_-_123404811 8.08 ENSMUST00000006525.14
ENSMUST00000064674.13
CBFA2/RUNX1 translocation partner 3
chr18_+_10617773 8.00 ENSMUST00000002551.5
ENSMUST00000234207.2
small nuclear ribonucleoprotein D1
chr1_+_175708341 7.95 ENSMUST00000195196.6
ENSMUST00000194306.6
ENSMUST00000193822.6
exonuclease 1
chr18_-_80756273 7.79 ENSMUST00000078049.12
ENSMUST00000236711.2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
chr15_-_79489286 7.77 ENSMUST00000229408.2
ENSMUST00000023065.8
DNA meiotic recombinase 1
chr9_-_21202353 7.71 ENSMUST00000086374.8
cyclin dependent kinase inhibitor 2D
chr8_-_106074585 7.67 ENSMUST00000014922.5
formin homology 2 domain containing 1
chr4_+_32615428 7.64 ENSMUST00000178925.8
ENSMUST00000029950.10
caspase 8 associated protein 2
chr13_-_22227114 7.61 ENSMUST00000091741.6
H2A clustered histone 11
chr9_+_61280501 7.49 ENSMUST00000162583.8
ENSMUST00000161993.8
ENSMUST00000160882.8
ENSMUST00000160724.8
ENSMUST00000162973.8
ENSMUST00000159050.8
transducin-like enhancer of split 3
chr2_-_118380149 7.35 ENSMUST00000090219.13
BCL2 modifying factor
chr6_+_113508636 7.34 ENSMUST00000036340.12
ENSMUST00000204827.3
Fanconi anemia, complementation group D2
chr4_-_43010225 7.30 ENSMUST00000030165.5
Fanconi anemia, complementation group G
chr6_+_21949570 7.28 ENSMUST00000031680.10
ENSMUST00000115389.8
ENSMUST00000151473.8
inhibitor of growth family, member 3
chr4_-_133694543 7.26 ENSMUST00000123234.8
high mobility group nucleosomal binding domain 2
chr1_-_93729562 7.23 ENSMUST00000112890.3
deoxythymidylate kinase
chr9_+_61280764 7.19 ENSMUST00000160541.8
ENSMUST00000161207.8
ENSMUST00000159630.8
transducin-like enhancer of split 3
chr12_+_11315868 7.18 ENSMUST00000020931.6
structural maintenance of chromosomes 6
chr9_-_13738304 7.14 ENSMUST00000148086.8
ENSMUST00000034398.12
centrosomal protein 57
chr4_+_140428777 7.13 ENSMUST00000138808.8
ENSMUST00000038893.6
regulator of chromosome condensation 2
chrX_-_72502595 7.13 ENSMUST00000033737.15
ENSMUST00000077243.5
HAUS augmin-like complex, subunit 7
chr10_+_128067934 7.05 ENSMUST00000055539.11
ENSMUST00000105244.8
ENSMUST00000105243.9
timeless circadian clock 1
chr7_-_44198157 6.97 ENSMUST00000145956.2
ENSMUST00000049343.15
polymerase (DNA directed), delta 1, catalytic subunit
chr1_-_74544946 6.97 ENSMUST00000044260.11
ENSMUST00000186282.7
ubiquitin specific peptidase 37
chr17_+_50816296 6.95 ENSMUST00000043938.8
phospholipase C-like 2
chr8_-_106434565 6.94 ENSMUST00000013299.11
enkurin domain containing 1
chr16_-_18630365 6.93 ENSMUST00000096990.10
cell division cycle 45
chr10_-_128361731 6.89 ENSMUST00000026427.8
extended synaptotagmin-like protein 1
chr3_+_116388600 6.88 ENSMUST00000198386.5
ENSMUST00000198311.5
ENSMUST00000197335.2
SAS-6 centriolar assembly protein
chr9_-_21202693 6.88 ENSMUST00000213407.2
cyclin dependent kinase inhibitor 2D
chr1_+_131838294 6.84 ENSMUST00000062264.8
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_34803988 6.82 ENSMUST00000028232.7
ENSMUST00000202907.2
PHD finger protein 19
chr5_+_114268425 6.79 ENSMUST00000031587.13
uracil DNA glycosylase
chr13_+_21900554 6.67 ENSMUST00000070124.5
H2A clustered histone 13
chr19_-_6014210 6.60 ENSMUST00000025752.15
ENSMUST00000165143.3
polymerase (DNA directed), alpha 2
chr11_-_6394385 6.50 ENSMUST00000109737.9
H2A.Z histone variant 2
chr3_+_127347099 6.48 ENSMUST00000043108.9
ENSMUST00000196141.5
ENSMUST00000195955.2
zinc finger, GRF-type containing 1
chr7_+_102090892 6.33 ENSMUST00000033283.10
ribonucleotide reductase M1
chr8_-_121316043 6.28 ENSMUST00000034278.6
GINS complex subunit 2 (Psf2 homolog)
chrX_+_41239548 6.18 ENSMUST00000069619.14
stromal antigen 2
chr6_-_8259098 6.15 ENSMUST00000012627.5
replication protein A3
chr9_-_36637670 6.13 ENSMUST00000172702.9
ENSMUST00000172742.2
checkpoint kinase 1
chr8_+_85598734 6.12 ENSMUST00000170296.2
ENSMUST00000136026.8
synaptonemal complex central element protein 2
chr9_-_36637923 6.03 ENSMUST00000034625.12
checkpoint kinase 1
chr2_-_132095146 5.96 ENSMUST00000028817.7
proliferating cell nuclear antigen
chr11_+_79883885 5.86 ENSMUST00000163272.2
ENSMUST00000017692.15
SUZ12 polycomb repressive complex 2 subunit
chr2_-_91067212 5.84 ENSMUST00000111352.8
damage specific DNA binding protein 2
chr9_+_13739003 5.79 ENSMUST00000059579.12
family with sequence similarity 76, member B
chr6_+_92068361 5.77 ENSMUST00000113460.8
nuclear receptor subfamily 2, group C, member 2
chr4_-_132570421 5.65 ENSMUST00000105919.2
ENSMUST00000030702.14
protein phosphatase 1, regulatory subunit 8
chr19_-_6014159 5.61 ENSMUST00000235224.2
polymerase (DNA directed), alpha 2
chr7_+_82516491 5.61 ENSMUST00000082237.7
mex3 RNA binding family member B
chr13_-_23929490 5.54 ENSMUST00000091752.5
H3 clustered histone 3
chr5_-_136596094 5.51 ENSMUST00000175975.9
ENSMUST00000176216.9
ENSMUST00000176745.8
cut-like homeobox 1
chr8_+_96360081 5.43 ENSMUST00000034094.11
ENSMUST00000212434.2
GINS complex subunit 3 (Psf3 homolog)
chr7_-_67022520 5.38 ENSMUST00000156690.8
ENSMUST00000107476.8
ENSMUST00000076325.12
ENSMUST00000032776.15
ENSMUST00000133074.2
myocyte enhancer factor 2A
chr12_+_33197753 5.15 ENSMUST00000146040.9
ataxin 7-like 1
chr12_+_33197776 5.14 ENSMUST00000125192.9
ENSMUST00000136644.8
ataxin 7-like 1
chr13_-_21937997 5.08 ENSMUST00000074752.4
H2A clustered histone 15
chr7_+_112806672 5.08 ENSMUST00000047321.9
ENSMUST00000210074.2
ENSMUST00000210238.2
aryl hydrocarbon receptor nuclear translocator-like
chr11_+_98441923 5.05 ENSMUST00000081033.13
ENSMUST00000107511.8
ENSMUST00000107509.8
ENSMUST00000017339.12
zona pellucida binding protein 2
chr9_+_61280890 5.00 ENSMUST00000161689.8
transducin-like enhancer of split 3
chr14_+_54443198 4.83 ENSMUST00000103728.2
T cell receptor alpha joining 13
chr11_+_85202058 4.83 ENSMUST00000020835.16
protein phosphatase 1D magnesium-dependent, delta isoform
chr15_-_97991114 4.81 ENSMUST00000180657.2
SUMO1/sentrin specific peptidase 1
chr5_+_137743992 4.78 ENSMUST00000100540.10
TSC22 domain family, member 4
chr4_-_133695204 4.77 ENSMUST00000100472.10
ENSMUST00000136327.2
high mobility group nucleosomal binding domain 2
chr2_+_164721277 4.77 ENSMUST00000041643.5
phosphorylated CTD interacting factor 1
chr12_-_4924341 4.76 ENSMUST00000137337.8
ENSMUST00000045921.14
major facilitator superfamily domain containing 2B
chr7_-_99770653 4.76 ENSMUST00000208670.2
ENSMUST00000032969.14
polymerase (DNA-directed), delta 3, accessory subunit
chr16_-_4377640 4.72 ENSMUST00000005862.9
transcription factor AP4
chr3_+_41517790 4.72 ENSMUST00000163764.8
jade family PHD finger 1
chr10_-_4337435 4.71 ENSMUST00000100077.5
zinc finger and BTB domain containing 2
chr12_-_75678092 4.66 ENSMUST00000238938.2
ribosomal protein, large P2, pseudogene 1
chr6_+_51447317 4.62 ENSMUST00000094623.10
chromobox 3
chr5_+_143846782 4.61 ENSMUST00000148011.8
ENSMUST00000110709.7
PMS1 homolog2, mismatch repair system component
chr2_+_132658055 4.57 ENSMUST00000028831.15
ENSMUST00000066559.6
minichromosome maintenance 8 homologous recombination repair factor
chr18_+_66591604 4.52 ENSMUST00000025399.9
ENSMUST00000237161.2
ENSMUST00000236933.2
phorbol-12-myristate-13-acetate-induced protein 1
chr1_+_74545203 4.52 ENSMUST00000087215.7
CCR4-NOT transcription complex, subunit 9
chr7_-_99770280 4.50 ENSMUST00000208184.2
polymerase (DNA-directed), delta 3, accessory subunit
chr1_+_131838220 4.49 ENSMUST00000189946.7
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr8_+_106363141 4.47 ENSMUST00000005841.16
CCCTC-binding factor
chr2_-_91067312 4.46 ENSMUST00000028696.5
damage specific DNA binding protein 2
chr2_+_84867783 4.44 ENSMUST00000168266.8
ENSMUST00000130729.3
structure specific recognition protein 1
chr13_-_47259266 4.44 ENSMUST00000129352.3
DEK proto-oncogene (DNA binding)
chr1_-_38168697 4.39 ENSMUST00000027251.12
REV1, DNA directed polymerase
chr2_+_53082079 4.36 ENSMUST00000028336.7
ADP-ribosylation factor-like 6 interacting protein 6
chr5_+_137744228 4.35 ENSMUST00000100539.10
TSC22 domain family, member 4
chr6_-_148847633 4.32 ENSMUST00000132696.8
SIN3-HDAC complex associated factor
chr15_-_81756076 4.30 ENSMUST00000023117.10
PHD finger protein 5A
chr15_+_58004753 4.27 ENSMUST00000067563.9
WDYHV motif containing 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.2 60.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
13.3 39.8 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
13.1 157.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
12.3 49.0 GO:0006272 leading strand elongation(GO:0006272)
11.5 34.6 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
10.8 64.8 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
8.4 25.3 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
7.3 130.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
7.0 7.0 GO:0045004 DNA replication proofreading(GO:0045004)
6.5 26.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
6.4 146.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
5.7 28.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
5.5 49.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
4.7 51.9 GO:0090166 Golgi disassembly(GO:0090166)
4.6 69.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
4.5 13.6 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
4.3 17.2 GO:0046722 lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
4.3 17.0 GO:0048478 replication fork protection(GO:0048478)
4.1 12.2 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
3.7 18.4 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
3.7 14.7 GO:0002337 B-1a B cell differentiation(GO:0002337)
3.6 35.5 GO:0019985 translesion synthesis(GO:0019985)
3.3 108.4 GO:0006270 DNA replication initiation(GO:0006270)
3.1 18.8 GO:0044838 cell quiescence(GO:0044838)
3.1 9.3 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
3.0 3.0 GO:0010159 specification of organ position(GO:0010159)
2.8 11.3 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
2.7 18.8 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
2.6 31.7 GO:0033504 floor plate development(GO:0033504)
2.6 21.1 GO:1902969 mitotic DNA replication(GO:1902969)
2.5 7.6 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
2.4 7.3 GO:1904093 regulation of autophagic cell death(GO:1904092) negative regulation of autophagic cell death(GO:1904093)
2.4 7.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
2.3 23.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
2.3 6.8 GO:0006285 base-excision repair, AP site formation(GO:0006285)
2.3 15.8 GO:0061010 gall bladder development(GO:0061010)
2.2 8.9 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to monosodium glutamate(GO:1904008) cellular response to monosodium glutamate(GO:1904009)
2.2 2.2 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
2.1 10.7 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
2.1 19.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
2.0 19.9 GO:0000722 telomere maintenance via recombination(GO:0000722)
1.9 23.3 GO:0048102 autophagic cell death(GO:0048102)
1.9 1.9 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
1.8 29.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
1.7 10.3 GO:0006290 pyrimidine dimer repair(GO:0006290)
1.7 11.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.6 8.2 GO:0034421 post-translational protein acetylation(GO:0034421)
1.6 3.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.5 10.8 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.5 9.3 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
1.5 13.3 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
1.4 7.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.4 25.7 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
1.4 5.6 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
1.4 23.8 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
1.4 8.3 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
1.4 9.6 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.3 5.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.3 12.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
1.3 52.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.3 12.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
1.2 7.4 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
1.1 25.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
1.1 4.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
1.1 7.8 GO:0042148 strand invasion(GO:0042148)
1.1 3.3 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.1 5.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
1.1 8.6 GO:0014043 negative regulation of neuron maturation(GO:0014043)
1.0 5.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
1.0 5.9 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
1.0 7.7 GO:0051660 establishment of centrosome localization(GO:0051660)
1.0 7.6 GO:0036337 Fas signaling pathway(GO:0036337)
0.9 10.2 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.9 6.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.8 9.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.8 16.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 8.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.8 7.8 GO:0035372 protein localization to microtubule(GO:0035372)
0.8 9.2 GO:0023035 CD40 signaling pathway(GO:0023035)
0.8 20.4 GO:0043486 histone exchange(GO:0043486)
0.8 4.5 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.7 4.2 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.7 42.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.7 38.1 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.7 8.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.7 15.0 GO:0006298 mismatch repair(GO:0006298)
0.7 8.7 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.6 2.4 GO:0001543 ovarian follicle rupture(GO:0001543)
0.6 1.8 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.5 6.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.5 16.2 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.5 7.5 GO:0080009 mRNA methylation(GO:0080009)
0.5 2.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.5 2.5 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.5 9.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.4 11.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.4 1.2 GO:0006021 inositol biosynthetic process(GO:0006021)
0.4 1.2 GO:0060939 transforming growth factor beta receptor complex assembly(GO:0007181) cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939)
0.4 2.0 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 3.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.4 4.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.4 4.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 4.7 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.4 2.5 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 1.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 3.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.4 1.1 GO:0072752 cellular response to rapamycin(GO:0072752)
0.3 3.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 1.4 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.3 15.9 GO:0006289 nucleotide-excision repair(GO:0006289)
0.3 5.1 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.3 2.8 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.3 0.3 GO:0072554 blood vessel lumenization(GO:0072554)
0.3 0.9 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.3 9.8 GO:0030033 microvillus assembly(GO:0030033)
0.3 3.5 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.3 10.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 5.6 GO:0072697 protein localization to cell cortex(GO:0072697)
0.3 1.4 GO:1904349 positive regulation of small intestine smooth muscle contraction(GO:1904349)
0.3 5.0 GO:0072189 ureter development(GO:0072189)
0.3 1.9 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.3 0.5 GO:0060061 Spemann organizer formation(GO:0060061)
0.3 18.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.3 1.6 GO:0034334 adherens junction maintenance(GO:0034334)
0.3 5.1 GO:0001675 acrosome assembly(GO:0001675)
0.3 16.5 GO:0043966 histone H3 acetylation(GO:0043966)
0.2 6.9 GO:0007099 centriole replication(GO:0007099)
0.2 5.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 7.1 GO:0034453 microtubule anchoring(GO:0034453)
0.2 1.4 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.2 1.6 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.2 0.6 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.2 3.8 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 5.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.2 5.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.2 24.2 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.2 11.0 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.2 2.1 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.2 2.5 GO:0043589 skin morphogenesis(GO:0043589)
0.1 2.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 1.6 GO:1904251 regulation of bile acid metabolic process(GO:1904251)
0.1 0.4 GO:0036090 cleavage furrow ingression(GO:0036090)
0.1 11.5 GO:0007569 cell aging(GO:0007569)
0.1 2.3 GO:0006857 oligopeptide transport(GO:0006857)
0.1 5.8 GO:0038066 p38MAPK cascade(GO:0038066)
0.1 2.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 2.6 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 4.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 7.3 GO:0001541 ovarian follicle development(GO:0001541)
0.1 5.4 GO:0032456 endocytic recycling(GO:0032456)
0.1 33.9 GO:0007018 microtubule-based movement(GO:0007018)
0.1 2.8 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 2.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 1.0 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 2.0 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.1 0.3 GO:0048880 proprioception(GO:0019230) sensory system development(GO:0048880)
0.1 2.8 GO:0048255 mRNA stabilization(GO:0048255)
0.1 1.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 5.8 GO:0051225 spindle assembly(GO:0051225)
0.1 0.7 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.5 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 1.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 3.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 2.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 17.8 GO:0048511 rhythmic process(GO:0048511)
0.0 2.3 GO:0001881 receptor recycling(GO:0001881)
0.0 0.5 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422)
0.0 0.5 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 1.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 1.7 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 0.4 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 11.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.3 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 5.0 GO:0006869 lipid transport(GO:0006869)
0.0 0.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
23.2 139.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
13.0 208.6 GO:0042555 MCM complex(GO:0042555)
9.9 49.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
9.1 27.4 GO:0000811 GINS complex(GO:0000811)
8.0 39.8 GO:0035189 Rb-E2F complex(GO:0035189)
4.8 24.0 GO:0031298 replication fork protection complex(GO:0031298)
4.1 32.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
4.0 27.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.7 25.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
3.2 12.8 GO:0035061 interchromatin granule(GO:0035061)
2.9 23.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
2.3 9.3 GO:0001740 Barr body(GO:0001740)
2.2 13.3 GO:0033553 rDNA heterochromatin(GO:0033553)
2.2 144.1 GO:0005657 replication fork(GO:0005657)
2.1 25.4 GO:0000796 condensin complex(GO:0000796)
2.0 11.7 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
1.9 11.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
1.8 16.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
1.4 8.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.4 38.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.3 8.9 GO:0005638 lamin filament(GO:0005638)
1.1 7.5 GO:0036396 MIS complex(GO:0036396)
1.0 5.1 GO:0031251 PAN complex(GO:0031251)
1.0 6.9 GO:0098536 deuterosome(GO:0098536)
0.9 4.6 GO:0032389 MutLalpha complex(GO:0032389)
0.9 3.5 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.8 2.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.8 24.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.8 2.5 GO:0005584 collagen type I trimer(GO:0005584)
0.8 5.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.8 7.1 GO:0070652 HAUS complex(GO:0070652)
0.8 24.5 GO:0035861 site of double-strand break(GO:0035861)
0.7 50.2 GO:0005876 spindle microtubule(GO:0005876)
0.7 7.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.7 1.4 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.7 4.7 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.6 6.1 GO:0000801 central element(GO:0000801)
0.6 3.7 GO:0044530 supraspliceosomal complex(GO:0044530)
0.6 9.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.6 10.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 112.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.5 38.1 GO:0005871 kinesin complex(GO:0005871)
0.4 16.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.4 1.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.4 4.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.4 2.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.4 4.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.4 4.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.4 19.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 3.8 GO:0000243 commitment complex(GO:0000243)
0.3 28.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 6.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.3 122.1 GO:0005667 transcription factor complex(GO:0005667)
0.3 2.2 GO:0000803 sex chromosome(GO:0000803)
0.3 5.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.3 1.6 GO:0001651 dense fibrillar component(GO:0001651)
0.2 3.9 GO:1904115 axon cytoplasm(GO:1904115)
0.2 1.4 GO:0034709 methylosome(GO:0034709)
0.2 9.1 GO:0090544 BAF-type complex(GO:0090544)
0.2 15.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.2 1.9 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 26.8 GO:0005814 centriole(GO:0005814)
0.2 4.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 42.5 GO:0005819 spindle(GO:0005819)
0.2 5.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 11.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 12.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 2.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 9.6 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 9.8 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 38.3 GO:0000785 chromatin(GO:0000785)
0.1 6.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.1 GO:0031931 TORC1 complex(GO:0031931)
0.1 7.6 GO:0016605 PML body(GO:0016605)
0.1 41.7 GO:0005813 centrosome(GO:0005813)
0.1 40.9 GO:0005694 chromosome(GO:0005694)
0.1 6.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 7.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0070938 contractile ring(GO:0070938)
0.1 5.9 GO:0016459 myosin complex(GO:0016459)
0.1 134.7 GO:0005654 nucleoplasm(GO:0005654)
0.1 0.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.4 GO:0061617 MICOS complex(GO:0061617)
0.1 3.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.8 GO:0000502 proteasome complex(GO:0000502)
0.0 12.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 178.4 GO:0005634 nucleus(GO:0005634)
0.0 6.3 GO:0005874 microtubule(GO:0005874)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.3 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
23.2 139.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
12.4 87.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
11.9 59.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
6.6 39.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
5.9 11.8 GO:0000405 bubble DNA binding(GO:0000405)
5.5 22.0 GO:0036033 mediator complex binding(GO:0036033)
4.6 18.4 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
4.6 41.0 GO:0000150 recombinase activity(GO:0000150)
4.2 76.2 GO:0003688 DNA replication origin binding(GO:0003688)
4.1 16.3 GO:0048256 flap endonuclease activity(GO:0048256)
3.8 34.6 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
3.2 19.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
3.1 31.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
3.0 12.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
2.7 27.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
2.7 13.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
2.6 133.7 GO:0003678 DNA helicase activity(GO:0003678)
2.5 12.6 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
2.5 52.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
2.4 7.2 GO:0004798 thymidylate kinase activity(GO:0004798)
2.0 6.0 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
1.9 5.8 GO:0070773 protein-N-terminal glutamine amidohydrolase activity(GO:0070773)
1.8 57.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.7 6.8 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
1.6 7.8 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
1.5 12.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
1.3 58.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.3 23.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.2 4.8 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
1.1 3.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
1.0 18.3 GO:1990226 histone methyltransferase binding(GO:1990226)
1.0 16.1 GO:0031386 protein tag(GO:0031386)
1.0 7.6 GO:0032184 SUMO polymer binding(GO:0032184)
0.9 8.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.9 2.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.9 10.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.8 26.1 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.7 9.6 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.7 5.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.6 8.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.6 3.9 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.6 19.8 GO:0008432 JUN kinase binding(GO:0008432)
0.6 9.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.6 4.6 GO:0032407 MutSalpha complex binding(GO:0032407)
0.6 60.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.5 154.8 GO:0001047 core promoter binding(GO:0001047)
0.5 34.8 GO:0035064 methylated histone binding(GO:0035064)
0.5 1.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.5 64.4 GO:0042393 histone binding(GO:0042393)
0.5 7.8 GO:0005522 profilin binding(GO:0005522)
0.5 59.2 GO:0004386 helicase activity(GO:0004386)
0.4 2.2 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.4 5.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105) transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.4 18.5 GO:0003684 damaged DNA binding(GO:0003684)
0.4 1.2 GO:0004512 inositol-3-phosphate synthase activity(GO:0004512) intramolecular lyase activity(GO:0016872)
0.4 14.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 2.8 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.3 2.4 GO:0034046 poly(G) binding(GO:0034046)
0.3 13.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 38.1 GO:0003777 microtubule motor activity(GO:0003777)
0.3 5.0 GO:0031996 thioesterase binding(GO:0031996)
0.3 0.9 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.3 1.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 15.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 7.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 6.9 GO:0050811 GABA receptor binding(GO:0050811)
0.3 1.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 2.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.3 2.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 6.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 3.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.2 65.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 5.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 7.6 GO:0070330 aromatase activity(GO:0070330)
0.2 5.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 1.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 13.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 8.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 4.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 0.7 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.2 3.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.2 2.0 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.2 1.0 GO:0035198 miRNA binding(GO:0035198)
0.2 71.1 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 1.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 2.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.7 GO:0070888 E-box binding(GO:0070888)
0.1 3.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 2.5 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.4 GO:0015288 porin activity(GO:0015288)
0.1 2.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 5.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 43.6 GO:0003682 chromatin binding(GO:0003682)
0.1 1.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 7.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 2.0 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 41.5 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.1 3.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 4.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 7.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 7.7 GO:0031072 heat shock protein binding(GO:0031072)
0.1 2.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 7.3 GO:0051087 chaperone binding(GO:0051087)
0.1 18.0 GO:0015631 tubulin binding(GO:0015631)
0.1 20.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 1.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 13.8 GO:0016887 ATPase activity(GO:0016887)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.2 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 79.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
5.1 92.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
4.1 202.9 PID ATR PATHWAY ATR signaling pathway
2.8 286.4 PID E2F PATHWAY E2F transcription factor network
1.2 18.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.1 31.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.9 58.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.9 25.0 PID MYC PATHWAY C-MYC pathway
0.9 50.5 PID PLK1 PATHWAY PLK1 signaling events
0.7 18.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 7.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5 10.2 PID IL5 PATHWAY IL5-mediated signaling events
0.4 21.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 27.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.3 6.2 PID ATM PATHWAY ATM pathway
0.3 34.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 10.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 6.0 PID BARD1 PATHWAY BARD1 signaling events
0.3 13.9 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.3 1.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.3 5.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 9.2 PID AURORA B PATHWAY Aurora B signaling
0.2 7.8 PID RHOA PATHWAY RhoA signaling pathway
0.2 13.9 PID NOTCH PATHWAY Notch signaling pathway
0.2 16.1 PID CMYB PATHWAY C-MYB transcription factor network
0.2 2.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 8.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 7.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 8.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 7.2 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 4.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 10.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.4 PID P73PATHWAY p73 transcription factor network
0.0 1.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
15.1 241.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
14.1 309.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
7.3 101.7 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
4.4 74.5 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
4.2 8.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
2.4 12.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
2.4 12.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
1.9 37.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
1.7 12.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.5 24.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.2 12.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.2 7.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.2 13.9 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.2 38.1 REACTOME KINESINS Genes involved in Kinesins
1.1 49.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.9 18.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.9 10.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.9 8.9 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.7 32.9 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.7 18.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.7 35.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.6 12.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.5 62.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.5 35.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 11.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.5 13.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 7.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.4 16.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.3 12.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 4.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 4.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 50.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 5.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 5.2 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.2 2.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 2.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 6.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 2.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 4.6 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 2.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 14.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 11.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 5.3 REACTOME MITOTIC G2 G2 M PHASES Genes involved in Mitotic G2-G2/M phases
0.1 6.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.6 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 1.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21