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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for E2f7

Z-value: 0.85

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Transcription factors associated with E2f7

Gene Symbol Gene ID Gene Info
E2f7
ENSMUSG00000020185.17 E2f7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f7mm39_v1_chr10_+_110581293_1105814330.741.2e-13Click!

Activity profile of E2f7 motif

Sorted Z-values of E2f7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_69188716 6.95 ENSMUST00000119827.8
ENSMUST00000020099.13
Cdk1
cyclin-dependent kinase 1
chr13_-_100912308 6.05 ENSMUST00000075550.4
Cenph
centromere protein H
chr4_+_108436639 5.40 ENSMUST00000102744.4
Orc1
origin recognition complex, subunit 1
chr12_+_24758240 5.00 ENSMUST00000020980.12
Rrm2
ribonucleotide reductase M2
chr11_+_98441923 4.76 ENSMUST00000081033.13
ENSMUST00000107511.8
ENSMUST00000107509.8
ENSMUST00000017339.12
Zpbp2
zona pellucida binding protein 2
chr12_+_24758968 4.74 ENSMUST00000154588.2
Rrm2
ribonucleotide reductase M2
chr2_+_72306503 4.59 ENSMUST00000102691.11
ENSMUST00000157019.2
Cdca7
cell division cycle associated 7
chr13_-_55477535 4.41 ENSMUST00000021941.8
Mxd3
Max dimerization protein 3
chr11_+_102139671 4.26 ENSMUST00000100392.5
Hrob
homologous recombination factor with OB-fold
chr2_+_11176891 4.25 ENSMUST00000028118.9
Prkcq
protein kinase C, theta
chr1_-_74544946 4.13 ENSMUST00000044260.11
ENSMUST00000186282.7
Usp37
ubiquitin specific peptidase 37
chr8_+_75836187 3.98 ENSMUST00000164309.3
ENSMUST00000212426.2
ENSMUST00000212811.2
Mcm5
minichromosome maintenance complex component 5
chr14_-_20438890 3.51 ENSMUST00000022345.7
Dnajc9
DnaJ heat shock protein family (Hsp40) member C9
chr11_+_85202058 3.51 ENSMUST00000020835.16
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chr6_-_88875646 3.49 ENSMUST00000058011.8
Mcm2
minichromosome maintenance complex component 2
chr15_-_27681584 3.38 ENSMUST00000226145.2
ENSMUST00000226170.2
Otulinl
OTU deubiquitinase with linear linkage specificity like
chr12_-_76756772 3.38 ENSMUST00000166101.2
Sptb
spectrin beta, erythrocytic
chr2_-_157046386 3.09 ENSMUST00000029170.8
Rbl1
RB transcriptional corepressor like 1
chr4_+_98812082 3.06 ENSMUST00000091358.11
Usp1
ubiquitin specific peptidase 1
chr4_+_98812047 3.05 ENSMUST00000030289.9
Usp1
ubiquitin specific peptidase 1
chr11_-_87295292 2.97 ENSMUST00000067692.13
Rad51c
RAD51 paralog C
chr17_-_35827676 2.87 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
Tcf19
transcription factor 19
chr15_-_27681643 2.86 ENSMUST00000100739.5
Otulinl
OTU deubiquitinase with linear linkage specificity like
chr6_+_30509826 2.80 ENSMUST00000031797.11
Ssmem1
serine-rich single-pass membrane protein 1
chr4_+_126450728 2.72 ENSMUST00000048391.15
Clspn
claspin
chr13_-_22227114 2.60 ENSMUST00000091741.6
H2ac11
H2A clustered histone 11
chr12_+_24758724 2.56 ENSMUST00000153058.8
Rrm2
ribonucleotide reductase M2
chr10_+_11157326 2.56 ENSMUST00000070300.5
Fbxo30
F-box protein 30
chr13_-_21937997 2.52 ENSMUST00000074752.4
H2ac15
H2A clustered histone 15
chr11_-_6394352 2.51 ENSMUST00000093346.6
H2az2
H2A.Z histone variant 2
chr10_+_115653152 2.50 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
Tspan8
tetraspanin 8
chr1_+_74545203 2.50 ENSMUST00000087215.7
Cnot9
CCR4-NOT transcription complex, subunit 9
chr10_+_11157047 2.46 ENSMUST00000129456.8
Fbxo30
F-box protein 30
chr14_-_52257113 2.45 ENSMUST00000166169.4
ENSMUST00000226605.2
Zfp219
zinc finger protein 219
chr14_+_79689230 2.20 ENSMUST00000100359.3
ENSMUST00000226192.2
Kbtbd6
kelch repeat and BTB (POZ) domain containing 6
chr3_+_108291145 2.20 ENSMUST00000090561.10
ENSMUST00000102629.8
ENSMUST00000128089.2
Psrc1
proline/serine-rich coiled-coil 1
chr12_-_11315755 2.13 ENSMUST00000166117.4
ENSMUST00000219600.2
ENSMUST00000218487.2
Gen1
GEN1, Holliday junction 5' flap endonuclease
chr17_+_35827997 2.07 ENSMUST00000164242.9
ENSMUST00000045956.14
Cchcr1
coiled-coil alpha-helical rod protein 1
chr13_-_22017677 2.05 ENSMUST00000081342.7
H2ac24
H2A clustered histone 24
chr9_+_64188857 1.98 ENSMUST00000215031.2
ENSMUST00000213165.2
ENSMUST00000213289.2
ENSMUST00000216594.2
ENSMUST00000034964.7
Tipin
timeless interacting protein
chr11_-_77404160 1.88 ENSMUST00000060417.11
Trp53i13
transformation related protein 53 inducible protein 13
chr3_+_88439616 1.87 ENSMUST00000172699.2
Mex3a
mex3 RNA binding family member A
chr13_+_21900554 1.82 ENSMUST00000070124.5
H2ac13
H2A clustered histone 13
chr4_+_98812144 1.81 ENSMUST00000169053.2
Usp1
ubiquitin specific peptidase 1
chr13_-_21967540 1.73 ENSMUST00000189457.2
H3c11
H3 clustered histone 11
chr3_+_60408678 1.72 ENSMUST00000191747.6
ENSMUST00000194069.6
Mbnl1
muscleblind like splicing factor 1
chr12_+_116369017 1.71 ENSMUST00000084828.5
ENSMUST00000222469.2
ENSMUST00000221114.2
ENSMUST00000221970.2
Ncapg2
non-SMC condensin II complex, subunit G2
chr1_+_153300874 1.67 ENSMUST00000042373.12
Shcbp1l
Shc SH2-domain binding protein 1-like
chr1_-_88629843 1.64 ENSMUST00000159814.2
Arl4c
ADP-ribosylation factor-like 4C
chr17_-_35069136 1.59 ENSMUST00000046022.16
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr17_+_35069347 1.58 ENSMUST00000097343.11
ENSMUST00000173357.8
ENSMUST00000173065.8
ENSMUST00000165953.3
Nelfe
negative elongation factor complex member E, Rdbp
chr15_+_82183143 1.58 ENSMUST00000023089.5
Wbp2nl
WBP2 N-terminal like
chr8_-_106074585 1.47 ENSMUST00000014922.5
Fhod1
formin homology 2 domain containing 1
chr3_-_105594865 1.46 ENSMUST00000090680.11
Ddx20
DEAD box helicase 20
chr11_+_95733109 1.42 ENSMUST00000107714.9
ENSMUST00000107711.8
Gngt2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr11_-_95733235 1.42 ENSMUST00000059026.10
Abi3
ABI family member 3
chr3_-_143908111 1.42 ENSMUST00000121796.8
Lmo4
LIM domain only 4
chr5_-_92496730 1.40 ENSMUST00000038816.13
ENSMUST00000118006.3
Cxcl10
chemokine (C-X-C motif) ligand 10
chr18_+_44237474 1.39 ENSMUST00000081271.7
Spink12
serine peptidase inhibitor, Kazal type 12
chr18_+_44237577 1.37 ENSMUST00000239465.2
Spink12
serine peptidase inhibitor, Kazal type 12
chr1_-_128287347 1.29 ENSMUST00000190495.2
ENSMUST00000027601.11
Mcm6
minichromosome maintenance complex component 6
chr17_-_35265702 1.25 ENSMUST00000097338.11
Msh5
mutS homolog 5
chr13_-_47259652 1.25 ENSMUST00000021807.13
ENSMUST00000135278.8
Dek
DEK proto-oncogene (DNA binding)
chr3_+_14598848 1.24 ENSMUST00000108370.9
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr9_+_54672032 1.20 ENSMUST00000034830.9
Crabp1
cellular retinoic acid binding protein I
chr3_-_143908060 1.20 ENSMUST00000121112.6
Lmo4
LIM domain only 4
chr6_-_67014383 1.19 ENSMUST00000043098.9
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr11_-_6394385 1.18 ENSMUST00000109737.9
H2az2
H2A.Z histone variant 2
chr14_-_66071337 1.18 ENSMUST00000225853.2
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr4_+_132495636 1.18 ENSMUST00000102561.11
Rpa2
replication protein A2
chr16_+_76810588 1.16 ENSMUST00000239066.2
ENSMUST00000023580.8
Usp25
ubiquitin specific peptidase 25
chr11_+_95733489 1.14 ENSMUST00000100532.10
ENSMUST00000036088.11
Gngt2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr7_+_27869115 1.14 ENSMUST00000042405.8
Fbl
fibrillarin
chr10_+_67374366 1.12 ENSMUST00000127820.2
Egr2
early growth response 2
chr13_+_21994588 1.11 ENSMUST00000091745.6
H2ac23
H2A clustered histone 23
chr11_-_106192627 1.09 ENSMUST00000103071.4
Gh
growth hormone
chr7_+_44465806 1.02 ENSMUST00000207103.2
ENSMUST00000118125.9
Nup62
Il4i1
nucleoporin 62
interleukin 4 induced 1
chr4_+_108477117 1.02 ENSMUST00000030320.13
Cc2d1b
coiled-coil and C2 domain containing 1B
chr3_+_103187162 1.01 ENSMUST00000106860.6
Trim33
tripartite motif-containing 33
chr11_-_69214593 0.97 ENSMUST00000092973.6
Cntrob
centrobin, centrosomal BRCA2 interacting protein
chr4_+_124608569 0.96 ENSMUST00000030734.5
Sf3a3
splicing factor 3a, subunit 3
chr3_+_14598927 0.95 ENSMUST00000163660.8
Lrrcc1
leucine rich repeat and coiled-coil domain containing 1
chr6_-_67014348 0.94 ENSMUST00000204369.2
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr1_+_180396478 0.93 ENSMUST00000027777.12
Parp1
poly (ADP-ribose) polymerase family, member 1
chr9_+_21279802 0.91 ENSMUST00000214474.2
Ilf3
interleukin enhancer binding factor 3
chr11_-_101357046 0.88 ENSMUST00000040430.8
Vat1
vesicle amine transport 1
chr12_+_73333641 0.85 ENSMUST00000153941.8
ENSMUST00000122920.8
ENSMUST00000101313.4
Slc38a6
solute carrier family 38, member 6
chr12_+_11315868 0.80 ENSMUST00000020931.6
Smc6
structural maintenance of chromosomes 6
chr2_+_112092271 0.75 ENSMUST00000028553.4
Nop10
NOP10 ribonucleoprotein
chr11_+_87018079 0.72 ENSMUST00000139532.2
Trim37
tripartite motif-containing 37
chr11_-_70300836 0.71 ENSMUST00000019065.10
ENSMUST00000135148.2
Pelp1
proline, glutamic acid and leucine rich protein 1
chr13_-_21934675 0.57 ENSMUST00000102983.2
H4c12
H4 clustered histone 12
chr6_-_134874778 0.57 ENSMUST00000165392.8
ENSMUST00000204880.3
ENSMUST00000203409.3
ENSMUST00000046255.14
ENSMUST00000111932.8
ENSMUST00000149375.8
ENSMUST00000116515.9
Gpr19
G protein-coupled receptor 19
chr14_-_18897750 0.55 ENSMUST00000178728.2
Gm3005
predicted gene 3005
chr9_+_81745723 0.49 ENSMUST00000057067.10
ENSMUST00000189832.7
ENSMUST00000189391.2
Mei4
meiotic double-stranded break formation protein 4
chr9_+_46194293 0.49 ENSMUST00000074957.5
Bud13
BUD13 homolog
chr3_+_88049633 0.48 ENSMUST00000001455.13
ENSMUST00000119251.8
Mef2d
myocyte enhancer factor 2D
chr13_+_22227359 0.46 ENSMUST00000110452.2
H2bc11
H2B clustered histone 11
chr14_-_18359247 0.42 ENSMUST00000170207.8
Gm8108
predicted gene 8108
chr7_-_98305737 0.42 ENSMUST00000205911.2
ENSMUST00000038359.6
ENSMUST00000206611.2
ENSMUST00000206619.2
Emsy
EMSY, BRCA2-interacting transcriptional repressor
chr15_-_97991114 0.39 ENSMUST00000180657.2
Senp1
SUMO1/sentrin specific peptidase 1
chr14_-_18659699 0.38 ENSMUST00000170480.8
Gm3002
predicted gene 3002
chr3_+_152101698 0.32 ENSMUST00000200570.5
Zzz3
zinc finger, ZZ domain containing 3
chr7_-_4687916 0.31 ENSMUST00000206306.2
ENSMUST00000205952.2
ENSMUST00000079970.6
Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr9_-_87137515 0.28 ENSMUST00000093802.6
Cep162
centrosomal protein 162
chr14_-_17398733 0.26 ENSMUST00000163719.8
Gm8281
predicted gene, 8281
chr6_-_113717689 0.25 ENSMUST00000032440.6
Sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr4_+_119280002 0.21 ENSMUST00000094819.5
Zmynd12
zinc finger, MYND domain containing 12
chr12_+_11316101 0.21 ENSMUST00000218866.2
Smc6
structural maintenance of chromosomes 6
chr4_+_126450762 0.20 ENSMUST00000147675.2
Clspn
claspin
chr9_-_111100859 0.19 ENSMUST00000035079.10
Mlh1
mutL homolog 1
chr11_+_26337194 0.17 ENSMUST00000136830.2
ENSMUST00000109509.8
Fancl
Fanconi anemia, complementation group L
chr15_-_81756076 0.17 ENSMUST00000023117.10
Phf5a
PHD finger protein 5A
chr4_-_108436514 0.16 ENSMUST00000079213.6
Prpf38a
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr7_-_98305986 0.12 ENSMUST00000205276.2
Emsy
EMSY, BRCA2-interacting transcriptional repressor
chr1_-_190915441 0.10 ENSMUST00000027941.14
Atf3
activating transcription factor 3
chr13_+_21938258 0.06 ENSMUST00000091709.3
H2bc15
H2B clustered histone 15
chr13_+_92491234 0.06 ENSMUST00000022218.6
Dhfr
dihydrofolate reductase
chrX_+_151789457 0.03 ENSMUST00000095755.4
Usp51
ubiquitin specific protease 51
chr19_-_11806388 0.03 ENSMUST00000061235.3
Olfr1417
olfactory receptor 1417
chr2_+_130509530 0.02 ENSMUST00000103193.5
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr1_+_172348611 0.02 ENSMUST00000085894.12
ENSMUST00000161140.8
ENSMUST00000162988.8
Cfap45
cilia and flagella associated protein 45
chr6_+_113054592 0.02 ENSMUST00000113157.8
Setd5
SET domain containing 5
chr14_-_17742998 0.01 ENSMUST00000165619.8
Gm3252
predicted gene 3252
chr4_+_33062999 0.01 ENSMUST00000108162.8
ENSMUST00000024035.9
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.7 7.9 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.6 3.0 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.6 6.4 GO:0090166 Golgi disassembly(GO:0090166)
0.5 12.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 4.2 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.5 1.6 GO:0035038 female pronucleus assembly(GO:0035038)
0.4 2.5 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 4.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 2.0 GO:0048478 replication fork protection(GO:0048478)
0.4 1.1 GO:0034963 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.4 1.1 GO:0021594 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.4 2.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 1.4 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.3 0.9 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.3 4.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.2 1.5 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 4.9 GO:0051382 kinetochore assembly(GO:0051382)
0.2 1.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 2.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.2 4.8 GO:0001675 acrosome assembly(GO:0001675)
0.2 3.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 1.2 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.2 1.7 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.2 1.6 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.2 1.2 GO:0044838 cell quiescence(GO:0044838)
0.2 2.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.7 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.9 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 1.6 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.1 2.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.5 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 4.0 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.7 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.2 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic metaphase plate congression(GO:0051311)
0.1 2.9 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 1.0 GO:0051026 chiasma assembly(GO:0051026)
0.1 1.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 3.4 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 1.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.2 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 2.2 GO:0090224 mitotic metaphase plate congression(GO:0007080) regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.0 3.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 1.1 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 2.5 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 1.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.4 GO:0016926 regulation of definitive erythrocyte differentiation(GO:0010724) protein desumoylation(GO:0016926)
0.0 0.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 2.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.7 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.8 8.9 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.6 3.0 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.5 1.6 GO:0055087 Ski complex(GO:0055087)
0.4 3.4 GO:0008091 spectrin(GO:0008091)
0.4 1.6 GO:0032021 NELF complex(GO:0032021)
0.3 4.8 GO:0042555 MCM complex(GO:0042555)
0.3 2.0 GO:0031298 replication fork protection complex(GO:0031298)
0.3 1.0 GO:0035061 interchromatin granule(GO:0035061)
0.2 0.7 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 1.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.7 GO:0000796 condensin complex(GO:0000796)
0.1 1.1 GO:0001651 dense fibrillar component(GO:0001651) granular component(GO:0001652)
0.1 1.7 GO:0072687 meiotic spindle(GO:0072687)
0.1 9.1 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 2.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 5.0 GO:0016235 aggresome(GO:0016235)
0.1 1.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.3 GO:0005879 axonemal microtubule(GO:0005879)
0.1 1.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.2 GO:0005715 chiasma(GO:0005712) late recombination nodule(GO:0005715)
0.1 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 5.1 GO:0000776 kinetochore(GO:0000776)
0.0 3.0 GO:0005814 centriole(GO:0005814)
0.0 4.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.5 GO:0014704 intercalated disc(GO:0014704)
0.0 1.2 GO:0000502 proteasome complex(GO:0000502)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 6.0 GO:0043515 kinetochore binding(GO:0043515)
0.7 3.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.6 5.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 2.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 7.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 1.1 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.3 1.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 6.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 1.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 4.2 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 1.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 12.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.7 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.4 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.9 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 3.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.2 GO:0019841 retinol binding(GO:0019841)
0.1 3.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 2.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 4.2 GO:0070035 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 1.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.6 GO:0050699 WW domain binding(GO:0050699)
0.0 1.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 7.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.5 GO:0005178 integrin binding(GO:0005178)
0.0 2.1 GO:0001047 core promoter binding(GO:0001047)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 8.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 9.6 PID ATR PATHWAY ATR signaling pathway
0.2 20.9 PID E2F PATHWAY E2F transcription factor network
0.1 2.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 4.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.1 PID AURORA A PATHWAY Aurora A signaling
0.0 2.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.7 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 2.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 24.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 8.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 7.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.3 6.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 5.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 4.2 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 3.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.9 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.1 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC