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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for E2f8

Z-value: 1.48

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
E2f8
ENSMUSG00000046179.18 E2f8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f8mm39_v1_chr7_-_48531344_485313670.855.3e-21Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_21036792 21.89 ENSMUST00000188495.8
Myb
myeloblastosis oncogene
chr2_+_162896602 21.23 ENSMUST00000018005.10
Mybl2
myeloblastosis oncogene-like 2
chr10_-_21036824 19.97 ENSMUST00000020158.9
Myb
myeloblastosis oncogene
chr17_+_56610321 16.40 ENSMUST00000001258.15
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr8_+_75836187 16.36 ENSMUST00000164309.3
ENSMUST00000212426.2
ENSMUST00000212811.2
Mcm5
minichromosome maintenance complex component 5
chr17_+_56610396 15.16 ENSMUST00000113038.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr3_-_90603013 13.93 ENSMUST00000069960.12
ENSMUST00000117167.2
S100a9
S100 calcium binding protein A9 (calgranulin B)
chr15_+_61857390 12.07 ENSMUST00000159327.2
ENSMUST00000167731.8
Myc
myelocytomatosis oncogene
chr15_+_61857226 11.93 ENSMUST00000161976.8
ENSMUST00000022971.8
Myc
myelocytomatosis oncogene
chr8_+_57964956 11.62 ENSMUST00000210871.2
Hmgb2
high mobility group box 2
chr19_+_38919353 11.47 ENSMUST00000025965.12
Hells
helicase, lymphoid specific
chr12_+_24758724 10.81 ENSMUST00000153058.8
Rrm2
ribonucleotide reductase M2
chr1_-_128287347 10.77 ENSMUST00000190495.2
ENSMUST00000027601.11
Mcm6
minichromosome maintenance complex component 6
chr6_-_88875646 10.36 ENSMUST00000058011.8
Mcm2
minichromosome maintenance complex component 2
chr5_+_123887759 10.12 ENSMUST00000031366.12
Kntc1
kinetochore associated 1
chr19_+_38919477 10.05 ENSMUST00000145051.2
Hells
helicase, lymphoid specific
chr12_+_24758968 9.95 ENSMUST00000154588.2
Rrm2
ribonucleotide reductase M2
chr10_+_127851031 9.29 ENSMUST00000178041.8
ENSMUST00000026461.8
Prim1
DNA primase, p49 subunit
chr7_-_44198157 9.28 ENSMUST00000145956.2
ENSMUST00000049343.15
Pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr9_-_36637670 9.20 ENSMUST00000172702.9
ENSMUST00000172742.2
Chek1
checkpoint kinase 1
chr9_-_36637923 8.98 ENSMUST00000034625.12
Chek1
checkpoint kinase 1
chr16_-_18630365 8.41 ENSMUST00000096990.10
Cdc45
cell division cycle 45
chr7_-_48530777 7.78 ENSMUST00000058745.15
E2f8
E2F transcription factor 8
chr7_-_48531344 7.63 ENSMUST00000119223.2
E2f8
E2F transcription factor 8
chr5_-_33809640 7.57 ENSMUST00000151081.2
ENSMUST00000139518.8
ENSMUST00000101354.10
Slbp
stem-loop binding protein
chr5_-_33809872 6.87 ENSMUST00000057551.14
Slbp
stem-loop binding protein
chr17_+_56347424 6.82 ENSMUST00000002914.10
Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr2_-_34803988 6.55 ENSMUST00000028232.7
ENSMUST00000202907.2
Phf19
PHD finger protein 19
chr17_+_88282472 6.00 ENSMUST00000005503.5
Msh6
mutS homolog 6
chr5_-_33809683 5.92 ENSMUST00000075670.13
Slbp
stem-loop binding protein
chr16_-_15455141 5.86 ENSMUST00000023353.4
Mcm4
minichromosome maintenance complex component 4
chr6_-_125262974 5.82 ENSMUST00000088246.6
Tuba3a
tubulin, alpha 3A
chr10_+_42736345 5.73 ENSMUST00000063063.14
Scml4
Scm polycomb group protein like 4
chr10_-_128361731 5.58 ENSMUST00000026427.8
Esyt1
extended synaptotagmin-like protein 1
chr16_+_10652910 5.18 ENSMUST00000037913.9
Rmi2
RecQ mediated genome instability 2
chr2_-_157046386 5.12 ENSMUST00000029170.8
Rbl1
RB transcriptional corepressor like 1
chr5_-_65492907 4.92 ENSMUST00000203581.3
Rfc1
replication factor C (activator 1) 1
chr1_-_93729650 4.80 ENSMUST00000027503.14
Dtymk
deoxythymidylate kinase
chr6_+_35154319 4.72 ENSMUST00000201374.4
ENSMUST00000043815.16
Nup205
nucleoporin 205
chr17_+_34596098 4.56 ENSMUST00000080254.7
Btnl1
butyrophilin-like 1
chr5_-_65492940 4.45 ENSMUST00000203471.3
ENSMUST00000172732.8
ENSMUST00000204965.3
Rfc1
replication factor C (activator 1) 1
chr7_+_101714943 4.35 ENSMUST00000094130.4
ENSMUST00000084843.10
Xndc1
Xntrpc
Xrcc1 N-terminal domain containing 1
Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
chr2_-_154411765 4.16 ENSMUST00000103145.11
E2f1
E2F transcription factor 1
chr13_+_19807274 3.84 ENSMUST00000222464.2
ENSMUST00000002883.7
Sfrp4
secreted frizzled-related protein 4
chr6_+_35154545 3.82 ENSMUST00000170234.2
Nup205
nucleoporin 205
chr15_+_78810919 3.78 ENSMUST00000089377.6
Lgals1
lectin, galactose binding, soluble 1
chr2_-_154411640 3.47 ENSMUST00000000894.6
E2f1
E2F transcription factor 1
chr13_+_44884740 3.44 ENSMUST00000173246.8
Jarid2
jumonji, AT rich interactive domain 2
chr16_-_18066591 3.42 ENSMUST00000115645.10
Ranbp1
RAN binding protein 1
chr1_+_131838294 3.33 ENSMUST00000062264.8
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr11_+_79883885 3.25 ENSMUST00000163272.2
ENSMUST00000017692.15
Suz12
SUZ12 polycomb repressive complex 2 subunit
chr19_+_4806544 3.15 ENSMUST00000182821.8
ENSMUST00000036744.8
Rbm4b
RNA binding motif protein 4B
chr8_-_107792264 2.96 ENSMUST00000034393.7
Tmed6
transmembrane p24 trafficking protein 6
chr9_-_35028100 2.86 ENSMUST00000034537.8
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr15_-_97991114 2.86 ENSMUST00000180657.2
Senp1
SUMO1/sentrin specific peptidase 1
chr7_+_101714692 2.74 ENSMUST00000106950.8
ENSMUST00000146450.8
Xndc1
Xrcc1 N-terminal domain containing 1
chr4_+_132495636 2.47 ENSMUST00000102561.11
Rpa2
replication protein A2
chr6_+_117894242 2.42 ENSMUST00000180020.8
ENSMUST00000177570.2
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr1_+_131838220 2.19 ENSMUST00000189946.7
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr19_+_4806859 2.13 ENSMUST00000237921.2
Rbm4b
RNA binding motif protein 4B
chr4_-_126861918 2.02 ENSMUST00000106108.9
Zmym4
zinc finger, MYM-type 4
chr2_-_45002902 2.00 ENSMUST00000076836.13
ENSMUST00000176732.8
ENSMUST00000200844.4
Zeb2
zinc finger E-box binding homeobox 2
chr2_-_155787197 1.92 ENSMUST00000040162.3
Gdf5
growth differentiation factor 5
chr15_+_55420795 1.88 ENSMUST00000022998.14
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr6_+_117893942 1.78 ENSMUST00000179478.8
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr17_+_34129221 1.74 ENSMUST00000174541.9
Daxx
Fas death domain-associated protein
chr5_+_137786031 1.73 ENSMUST00000035852.14
Zcwpw1
zinc finger, CW type with PWWP domain 1
chr17_-_35454729 1.72 ENSMUST00000048994.7
Nfkbil1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr5_+_75312939 1.70 ENSMUST00000202681.4
ENSMUST00000000476.15
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chrX_-_41000746 1.70 ENSMUST00000047037.15
Thoc2
THO complex 2
chr11_+_87938519 1.59 ENSMUST00000079866.11
Srsf1
serine and arginine-rich splicing factor 1
chr2_-_45003270 1.53 ENSMUST00000202935.4
ENSMUST00000068415.11
ENSMUST00000127520.8
Zeb2
zinc finger E-box binding homeobox 2
chr2_-_91067212 1.43 ENSMUST00000111352.8
Ddb2
damage specific DNA binding protein 2
chr9_+_21914296 1.42 ENSMUST00000003493.9
Prkcsh
protein kinase C substrate 80K-H
chr13_+_44884757 1.41 ENSMUST00000174086.2
Jarid2
jumonji, AT rich interactive domain 2
chr10_+_42736539 1.39 ENSMUST00000157071.8
Scml4
Scm polycomb group protein like 4
chr17_+_34128382 1.39 ENSMUST00000173028.8
ENSMUST00000079421.15
Daxx
Fas death domain-associated protein
chr9_+_21914334 1.39 ENSMUST00000115331.10
Prkcsh
protein kinase C substrate 80K-H
chr7_-_128342158 1.38 ENSMUST00000119081.2
ENSMUST00000057557.14
Mcmbp
minichromosome maintenance complex binding protein
chr4_+_63133639 1.32 ENSMUST00000036300.13
Col27a1
collagen, type XXVII, alpha 1
chr9_+_21914083 1.26 ENSMUST00000216344.2
Prkcsh
protein kinase C substrate 80K-H
chr6_+_125016723 1.21 ENSMUST00000140131.8
ENSMUST00000032480.14
Ing4
inhibitor of growth family, member 4
chr10_+_19232281 1.17 ENSMUST00000053225.7
Olig3
oligodendrocyte transcription factor 3
chr6_+_116241146 1.17 ENSMUST00000112900.9
ENSMUST00000036503.14
ENSMUST00000223495.2
Zfand4
zinc finger, AN1-type domain 4
chr17_+_34128455 1.13 ENSMUST00000173626.8
ENSMUST00000170075.9
Daxx
Fas death domain-associated protein
chr17_+_29020744 1.08 ENSMUST00000136233.2
Brpf3
bromodomain and PHD finger containing, 3
chr2_-_91067312 1.00 ENSMUST00000028696.5
Ddb2
damage specific DNA binding protein 2
chr16_-_45352346 0.94 ENSMUST00000232600.2
Gm17783
predicted gene, 17783
chr9_+_100525501 0.90 ENSMUST00000146312.8
ENSMUST00000129269.8
Stag1
stromal antigen 1
chr6_+_38528738 0.89 ENSMUST00000161227.8
Luc7l2
LUC7-like 2 (S. cerevisiae)
chr11_+_26337194 0.83 ENSMUST00000136830.2
ENSMUST00000109509.8
Fancl
Fanconi anemia, complementation group L
chr13_+_95012107 0.79 ENSMUST00000022195.13
Otp
orthopedia homeobox
chr5_-_137785903 0.67 ENSMUST00000196022.2
Mepce
methylphosphate capping enzyme
chr15_+_101071948 0.39 ENSMUST00000000544.12
Acvr1b
activin A receptor, type 1B
chrX_-_167970196 0.23 ENSMUST00000066112.12
ENSMUST00000112118.8
ENSMUST00000112120.8
ENSMUST00000112119.8
Amelx
amelogenin, X-linked
chr9_+_21914513 0.22 ENSMUST00000215795.2
Prkcsh
protein kinase C substrate 80K-H
chr12_-_55045887 0.12 ENSMUST00000173529.2
Baz1a
bromodomain adjacent to zinc finger domain 1A

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
6.0 24.0 GO:0090096 lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
5.1 15.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
4.6 13.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.1 46.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
3.1 9.3 GO:0045004 DNA replication proofreading(GO:0045004)
2.9 53.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
2.8 8.4 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.5 7.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
2.3 9.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
2.2 27.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.9 20.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.6 4.8 GO:0006233 dTDP biosynthetic process(GO:0006233) dTDP metabolic process(GO:0046072)
1.4 5.5 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
1.3 3.8 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
1.3 3.8 GO:0034117 erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
1.2 11.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
1.0 20.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.0 6.0 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.9 3.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.9 4.3 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.8 4.6 GO:0045062 extrathymic T cell selection(GO:0045062)
0.7 6.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.6 6.8 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 16.4 GO:0006270 DNA replication initiation(GO:0006270)
0.5 3.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.5 8.5 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.5 3.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.4 1.7 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.3 1.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 2.4 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.3 1.9 GO:0060591 chondroblast differentiation(GO:0060591)
0.3 21.2 GO:0090307 mitotic spindle assembly(GO:0090307)
0.2 1.2 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.2 2.9 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 1.7 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.2 1.3 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.2 5.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 4.3 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 5.2 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.1 5.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 0.4 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 1.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.7 GO:0040031 snRNA modification(GO:0040031)
0.1 9.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 0.8 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 2.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 7.5 GO:0006260 DNA replication(GO:0006260)
0.0 1.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 5.6 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 21.2 GO:0031523 Myb complex(GO:0031523)
3.5 20.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
3.4 10.1 GO:1990423 RZZ complex(GO:1990423)
2.8 8.4 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
2.8 44.7 GO:0042555 MCM complex(GO:0042555)
2.5 20.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
1.9 9.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.7 6.8 GO:0033186 CAF-1 complex(GO:0033186)
1.6 9.4 GO:0005663 DNA replication factor C complex(GO:0005663)
1.5 7.6 GO:0035189 Rb-E2F complex(GO:0035189)
1.3 9.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.2 8.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.9 4.3 GO:0017177 glucosidase II complex(GO:0017177)
0.8 52.2 GO:0005657 replication fork(GO:0005657)
0.7 6.0 GO:0032300 mismatch repair complex(GO:0032300)
0.6 21.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.5 14.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 24.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 2.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 5.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 1.7 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 3.4 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.4 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 4.3 GO:0001741 XY body(GO:0001741)
0.1 1.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.9 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 16.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 12.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.2 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 12.0 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.7 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 41.9 GO:0071987 WD40-repeat domain binding(GO:0071987)
5.1 20.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
4.5 18.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
4.5 31.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
3.5 20.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.1 9.3 GO:0003896 DNA primase activity(GO:0003896)
2.6 25.5 GO:0050786 RAGE receptor binding(GO:0050786)
2.4 21.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.0 6.0 GO:0032142 single guanine insertion binding(GO:0032142)
2.0 35.1 GO:0003688 DNA replication origin binding(GO:0003688)
1.6 4.8 GO:0004798 thymidylate kinase activity(GO:0004798)
0.9 3.8 GO:0048030 disaccharide binding(GO:0048030)
0.9 9.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 2.9 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.6 6.8 GO:0070087 chromo shadow domain binding(GO:0070087)
0.6 1.7 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.5 9.3 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.4 2.9 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.4 16.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 3.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 24.0 GO:0070888 E-box binding(GO:0070888)
0.3 8.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 1.9 GO:0036122 BMP binding(GO:0036122)
0.2 2.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 3.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 5.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 21.5 GO:0004386 helicase activity(GO:0004386)
0.1 4.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 3.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 4.9 GO:0032452 histone demethylase activity(GO:0032452)
0.1 4.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 7.8 GO:0035064 methylated histone binding(GO:0035064)
0.1 3.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 23.0 GO:0001047 core promoter binding(GO:0001047)
0.1 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 2.4 GO:0003684 damaged DNA binding(GO:0003684)
0.0 4.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 4.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 10.2 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 16.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.0 73.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.5 50.5 PID E2F PATHWAY E2F transcription factor network
0.4 13.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 21.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 12.8 PID ATR PATHWAY ATR signaling pathway
0.2 9.4 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 4.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.8 PID RAS PATHWAY Regulation of Ras family activation
0.1 6.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 1.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 5.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 3.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 51.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.6 20.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.4 16.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.3 28.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.2 18.6 REACTOME POL SWITCHING Genes involved in Polymerase switching
1.0 19.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.9 11.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.6 24.0 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.5 2.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 4.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 8.5 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2 35.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 4.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 6.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.4 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 3.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.7 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction