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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Ebf1
Z-value: 2.05
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Transcription factors associated with Ebf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf1 | mm39_v1_chr11_+_44508137_44508169 | -0.01 | 9.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 65.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.3 | 44.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.7 | 18.7 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.7 | 17.8 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.7 | 17.6 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 1.5 | 15.2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 2.8 | 13.9 | GO:0015793 | glycerol transport(GO:0015793) |
| 3.3 | 13.2 | GO:0007113 | endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) |
| 0.7 | 13.0 | GO:0002385 | organ or tissue specific immune response(GO:0002251) mucosal immune response(GO:0002385) |
| 2.5 | 12.7 | GO:0002905 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 93.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 76.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 67.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 51.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 48.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 29.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 28.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 26.2 | GO:0043296 | apical junction complex(GO:0043296) |
| 1.8 | 21.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 18.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 55.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 37.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 31.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 29.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 23.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.5 | 23.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.2 | 19.3 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.2 | 19.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 16.3 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.3 | 16.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 24.3 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.4 | 23.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 22.7 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 20.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 18.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 17.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 15.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 15.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 15.1 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 39.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 25.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.7 | 24.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 19.2 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.9 | 18.5 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.3 | 16.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 15.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 13.6 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.5 | 12.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 11.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |