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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Elf5
Z-value: 2.27
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Transcription factors associated with Elf5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf5 | mm39_v1_chr2_+_103242027_103242041 | -0.09 | 4.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 37.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 35.7 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.1 | 26.3 | GO:0043413 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 1.1 | 23.2 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.6 | 18.8 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.7 | 17.9 | GO:0097340 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 3.3 | 16.3 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 1.4 | 15.6 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.2 | 15.6 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 1.1 | 14.9 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 147.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 40.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.3 | 38.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 34.5 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.1 | 31.1 | GO:0005903 | brush border(GO:0005903) |
| 0.4 | 27.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.5 | 25.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.3 | 25.3 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 21.6 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.3 | 20.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 38.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 34.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 23.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 20.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.5 | 20.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 18.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.6 | 18.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.6 | 18.5 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.3 | 18.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 22.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 21.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.1 | 17.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.3 | 15.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 15.0 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 14.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 14.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 13.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.4 | 13.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 35.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.5 | 31.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.7 | 27.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.7 | 22.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.3 | 22.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.1 | 20.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 1.0 | 20.6 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.5 | 17.8 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.5 | 16.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.5 | 15.9 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |