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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Epas1_Bcl3
Z-value: 2.73
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Transcription factors associated with Epas1_Bcl3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bcl3 | mm39_v1_chr7_-_19556612_19556712 | -0.70 | 9.6e-12 | Click! |
| Epas1 | mm39_v1_chr17_+_87061117_87061137 | 0.26 | 3.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Epas1_Bcl3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 104.7 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 2.0 | 59.5 | GO:0030204 | chondroitin sulfate metabolic process(GO:0030204) |
| 0.5 | 52.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 1.0 | 47.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.3 | 44.2 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.6 | 39.9 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 3.0 | 39.5 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 7.6 | 37.9 | GO:0007207 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.3 | 36.3 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 2.7 | 34.5 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 89.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 67.0 | GO:0030424 | axon(GO:0030424) |
| 1.0 | 61.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.5 | 59.7 | GO:0034705 | potassium channel complex(GO:0034705) |
| 2.3 | 49.6 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 47.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.3 | 44.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.1 | 41.2 | GO:0045202 | synapse(GO:0045202) |
| 1.4 | 39.8 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 1.8 | 39.5 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 105.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 1.0 | 88.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.1 | 64.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.3 | 59.6 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.6 | 52.7 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 4.2 | 50.4 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 7.7 | 46.3 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.4 | 46.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.6 | 46.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.6 | 41.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 48.6 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.5 | 30.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.4 | 29.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 23.8 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 22.3 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.2 | 18.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 17.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 17.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.4 | 16.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 14.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 53.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 1.0 | 49.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 2.3 | 48.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.9 | 46.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.3 | 45.2 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 43.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 37.9 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 35.9 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 1.1 | 33.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 1.1 | 26.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |