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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Erg
Z-value: 3.02
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Transcription factors associated with Erg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Erg | mm39_v1_chr16_-_95260104_95260243 | 0.73 | 3.1e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Erg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 41.6 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.3 | 33.7 | GO:0030183 | B cell differentiation(GO:0030183) |
| 2.5 | 33.1 | GO:0070474 | positive regulation of uterine smooth muscle contraction(GO:0070474) |
| 3.4 | 30.9 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.9 | 29.0 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.2 | 28.4 | GO:0007596 | blood coagulation(GO:0007596) |
| 0.9 | 28.0 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 1.2 | 27.8 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.8 | 26.5 | GO:0002467 | germinal center formation(GO:0002467) |
| 1.7 | 26.4 | GO:0045086 | positive regulation of interleukin-2 biosynthetic process(GO:0045086) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 130.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 75.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 43.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 43.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 43.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 42.7 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 1.4 | 40.4 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 1.2 | 35.8 | GO:0000242 | pericentriolar material(GO:0000242) |
| 6.2 | 30.9 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 1.9 | 29.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 91.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 64.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.5 | 64.4 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 0.5 | 45.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 4.2 | 41.5 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.3 | 37.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.7 | 36.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.5 | 36.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 6.6 | 33.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 1.3 | 33.0 | GO:0051400 | BH domain binding(GO:0051400) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 100.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.2 | 84.8 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.8 | 65.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.3 | 55.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 51.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.4 | 49.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.6 | 32.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.8 | 32.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.7 | 28.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.8 | 27.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 98.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 62.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 4.5 | 49.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 45.7 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.8 | 41.9 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.3 | 37.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 27.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 26.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.3 | 25.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 25.0 | REACTOME G PROTEIN BETA GAMMA SIGNALLING | Genes involved in G-protein beta:gamma signalling |