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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Esr2
Z-value: 2.73
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Transcription factors associated with Esr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esr2 | mm39_v1_chr12_-_76224025_76224039 | -0.28 | 1.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Esr2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_46146558 Show fit | 24.43 |
ENSMUST00000121916.8
ENSMUST00000034586.9 |
apolipoprotein C-III |
|
| chr9_-_46146928 Show fit | 19.72 |
ENSMUST00000118649.8
|
apolipoprotein C-III |
|
| chr9_+_46179899 Show fit | 19.18 |
ENSMUST00000121598.8
|
apolipoprotein A-V |
|
| chr10_+_76411474 Show fit | 18.26 |
ENSMUST00000001183.8
|
formiminotransferase cyclodeaminase |
|
| chr10_+_87357782 Show fit | 14.29 |
ENSMUST00000219813.2
|
phenylalanine hydroxylase |
|
| chr4_-_63072367 Show fit | 14.28 |
ENSMUST00000030041.5
|
alpha 1 microglobulin/bikunin precursor |
|
| chr10_+_87357657 Show fit | 14.16 |
ENSMUST00000020241.17
|
phenylalanine hydroxylase |
|
| chr3_+_94840352 Show fit | 13.83 |
ENSMUST00000090839.12
|
selenium binding protein 1 |
|
| chr11_+_102036356 Show fit | 13.62 |
ENSMUST00000055409.6
|
N-acetylglutamate synthase |
|
| chr7_+_26819334 Show fit | 13.57 |
ENSMUST00000003100.10
|
cytochrome P450, family 2, subfamily f, polypeptide 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 123.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 119.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.8 | 54.7 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 3.1 | 52.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 4.3 | 47.5 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 11.0 | 44.2 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 1.2 | 44.0 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 1.1 | 43.7 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 5.4 | 43.2 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.4 | 42.3 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 270.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 227.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 146.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 108.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 100.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 77.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 6.3 | 69.8 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 52.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 3.7 | 51.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 4.1 | 49.5 | GO:0042627 | chylomicron(GO:0042627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 142.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.0 | 129.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.5 | 76.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 63.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.4 | 57.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 3.0 | 54.2 | GO:0046977 | TAP binding(GO:0046977) |
| 12.1 | 48.6 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.4 | 47.3 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 11.5 | 46.1 | GO:0047016 | cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity(GO:0047016) |
| 7.5 | 45.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 111.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.3 | 107.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 54.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.3 | 44.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.8 | 43.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.9 | 24.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.4 | 23.6 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.5 | 21.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 21.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 20.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 124.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.6 | 121.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 4.6 | 69.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.8 | 63.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.0 | 54.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.7 | 54.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.3 | 45.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.8 | 42.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 3.0 | 41.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.7 | 41.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |