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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Esrrb_Esrra
Z-value: 3.06
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Transcription factors associated with Esrrb_Esrra
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esrra | mm39_v1_chr19_-_6899173_6899208 | 0.53 | 1.8e-06 | Click! |
| Esrrb | mm39_v1_chr12_+_86468401_86468436 | 0.42 | 2.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Esrrb_Esrra
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.0 | 132.1 | GO:0021941 | radial glia guided migration of cerebellar granule cell(GO:0021933) negative regulation of cerebellar granule cell precursor proliferation(GO:0021941) |
| 0.5 | 64.3 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.4 | 50.0 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 5.2 | 46.7 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 14.5 | 43.4 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 1.9 | 43.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.8 | 40.6 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 1.6 | 40.5 | GO:0007614 | short-term memory(GO:0007614) |
| 1.4 | 40.3 | GO:1905144 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 2.5 | 38.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 383.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.3 | 109.6 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.4 | 91.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.4 | 85.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.8 | 75.1 | GO:0044455 | mitochondrial membrane part(GO:0044455) |
| 1.0 | 55.3 | GO:0030673 | axolemma(GO:0030673) |
| 1.9 | 54.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.9 | 53.1 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 52.7 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 51.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.1 | 91.9 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.2 | 71.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.2 | 64.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 52.1 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 1.1 | 46.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.6 | 44.4 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 13.8 | 41.3 | GO:0080130 | L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.4 | 39.6 | GO:0005518 | collagen binding(GO:0005518) |
| 2.2 | 38.1 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 1.2 | 37.3 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 45.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 37.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.6 | 33.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.7 | 17.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.7 | 16.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.4 | 15.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 15.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 15.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 14.6 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.3 | 14.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 119.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.9 | 71.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 2.7 | 63.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.7 | 51.1 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.5 | 46.2 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.9 | 43.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 2.3 | 41.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 2.9 | 40.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.9 | 40.6 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 1.1 | 37.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |