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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Esrrg
Z-value: 1.17
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Transcription factors associated with Esrrg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esrrg | mm39_v1_chr1_+_187340952_187340988 | 0.15 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Esrrg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 17.4 | GO:0042694 | muscle cell fate specification(GO:0042694) |
| 0.2 | 16.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.2 | 11.6 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.4 | 10.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 1.1 | 9.8 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 1.4 | 8.4 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.2 | 8.3 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.2 | 7.9 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.3 | 7.8 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
| 0.5 | 7.7 | GO:0016576 | histone dephosphorylation(GO:0016576) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 30.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 18.8 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 14.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.8 | 12.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.8 | 9.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 8.8 | GO:0030017 | sarcomere(GO:0030017) |
| 0.1 | 7.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 7.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.5 | 7.7 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.8 | 7.5 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 29.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.7 | 12.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 10.3 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 2.0 | 9.8 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.0 | 9.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.3 | 9.3 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.8 | 8.2 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.1 | 7.9 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 7.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.9 | 7.5 | GO:0043532 | angiostatin binding(GO:0043532) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.7 | 17.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 15.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 8.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 6.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 5.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 3.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 3.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.7 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 40.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 20.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 16.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.6 | 15.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 12.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.2 | 7.2 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 6.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.6 | 6.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 6.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 5.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |