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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Ets1
Z-value: 2.86
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Transcription factors associated with Ets1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ets1 | mm39_v1_chr9_+_32607301_32607417 | 0.86 | 9.7e-22 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ets1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_126817475 Show fit | 45.14 |
ENSMUST00000106313.8
ENSMUST00000142356.3 |
septin 1 |
|
| chr7_-_126817639 Show fit | 44.01 |
ENSMUST00000152267.8
ENSMUST00000106314.8 |
septin 1 |
|
| chr19_-_4240984 Show fit | 27.34 |
ENSMUST00000045864.4
|
TBC1 domain family, member 10c |
|
| chr19_-_4241034 Show fit | 26.94 |
ENSMUST00000237495.2
|
TBC1 domain family, member 10c |
|
| chr7_-_126736979 Show fit | 25.74 |
ENSMUST00000049931.6
|
sialophorin |
|
| chr19_+_4204605 Show fit | 25.28 |
ENSMUST00000061086.9
|
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein |
|
| chr1_-_133617824 Show fit | 25.01 |
ENSMUST00000189524.2
ENSMUST00000169295.8 |
lymphocyte transmembrane adaptor 1 |
|
| chr17_+_34808772 Show fit | 23.88 |
ENSMUST00000038244.15
|
G-protein signalling modulator 3 (AGS3-like, C. elegans) |
|
| chr17_+_34809132 Show fit | 23.36 |
ENSMUST00000173772.2
|
G-protein signalling modulator 3 (AGS3-like, C. elegans) |
|
| chr4_-_129467430 Show fit | 23.15 |
ENSMUST00000102596.8
|
lymphocyte protein tyrosine kinase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 83.6 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 8.2 | 73.9 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 5.1 | 66.9 | GO:0045588 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) |
| 0.4 | 59.0 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 2.2 | 55.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 5.8 | 52.5 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 3.2 | 47.3 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 2.3 | 44.1 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 5.3 | 42.4 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 36.0 | GO:0008380 | RNA splicing(GO:0008380) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 180.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 2.1 | 107.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.9 | 75.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.1 | 75.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 3.6 | 71.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 5.9 | 70.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 12.3 | 61.5 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.2 | 60.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 52.8 | GO:0016605 | PML body(GO:0016605) |
| 1.5 | 51.7 | GO:0031527 | filopodium membrane(GO:0031527) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 138.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 89.8 | GO:0003677 | DNA binding(GO:0003677) |
| 0.5 | 81.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.4 | 70.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.1 | 62.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 12.3 | 61.5 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 1.1 | 59.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 11.3 | 56.6 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.7 | 52.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 51.5 | GO:0003682 | chromatin binding(GO:0003682) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 288.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.4 | 84.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 2.0 | 68.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.6 | 65.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.9 | 48.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.9 | 45.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 1.2 | 43.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.5 | 39.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 1.4 | 38.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.7 | 37.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 132.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 2.2 | 127.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 111.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.8 | 104.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 1.3 | 83.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.5 | 66.3 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 1.4 | 64.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.8 | 43.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 42.7 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 4.2 | 42.0 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |