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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Etv3_Erf_Fev_Elk4_Elk1_Elk3
Z-value: 3.02
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Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000003382.19 | Etv3 | |
| ENSMUSG00000040857.16 | Erf | |
| ENSMUSG00000055197.5 | Fev | |
| ENSMUSG00000026436.16 | Elk4 | |
| ENSMUSG00000009406.14 | Elk1 | |
| ENSMUSG00000008398.17 | Elk3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elk3 | mm39_v1_chr10_-_93146825_93146851 | -0.64 | 1.1e-09 | Click! |
| Elk4 | mm39_v1_chr1_+_131936022_131936054 | -0.53 | 1.9e-06 | Click! |
| Etv3 | mm39_v1_chr3_+_87432879_87432983 | -0.44 | 1.1e-04 | Click! |
| Elk1 | mm39_v1_chrX_-_20816841_20816852 | 0.20 | 9.4e-02 | Click! |
| Erf | mm39_v1_chr7_-_24950145_24950186 | 0.11 | 3.4e-01 | Click! |
| Fev | mm39_v1_chr1_-_74924481_74924578 | 0.02 | 8.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_48707763 Show fit | 86.18 |
ENSMUST00000140800.2
|
tripartite motif-containing 41 |
|
| chr11_-_48708159 Show fit | 84.74 |
ENSMUST00000047145.14
|
tripartite motif-containing 41 |
|
| chr9_-_60595401 Show fit | 36.46 |
ENSMUST00000114034.9
ENSMUST00000065603.12 |
leucine rich repeat containing 49 |
|
| chr2_+_91480513 Show fit | 34.06 |
ENSMUST00000090614.11
|
Rho GTPase activating protein 1 |
|
| chr1_-_121255448 Show fit | 32.71 |
ENSMUST00000186915.2
ENSMUST00000160968.8 ENSMUST00000162582.2 |
insulin induced gene 2 |
|
| chr1_-_121255503 Show fit | 30.02 |
ENSMUST00000160688.2
|
insulin induced gene 2 |
|
| chr1_-_121255400 Show fit | 29.08 |
ENSMUST00000159085.8
ENSMUST00000159125.2 ENSMUST00000161818.2 |
insulin induced gene 2 |
|
| chr17_+_35354172 Show fit | 27.26 |
ENSMUST00000172571.8
ENSMUST00000173491.8 |
BCL2-associated athanogene 6 |
|
| chr1_-_121255753 Show fit | 26.76 |
ENSMUST00000003818.14
|
insulin induced gene 2 |
|
| chr17_+_35354148 Show fit | 26.01 |
ENSMUST00000166426.9
ENSMUST00000025250.14 |
BCL2-associated athanogene 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.6 | 118.6 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 10.9 | 87.0 | GO:1904378 | maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.9 | 78.0 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 3.9 | 73.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 1.1 | 63.8 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 1.7 | 59.7 | GO:0017004 | cytochrome complex assembly(GO:0017004) |
| 9.6 | 57.6 | GO:0032439 | endosome localization(GO:0032439) |
| 3.2 | 54.7 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 10.8 | 54.2 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.9 | 52.6 | GO:0032543 | mitochondrial translation(GO:0032543) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 178.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 159.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 14.8 | 118.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 115.4 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.4 | 96.6 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 10.0 | 89.8 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 3.1 | 76.3 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 0.2 | 76.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.2 | 73.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 1.0 | 69.2 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 171.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.2 | 122.8 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.3 | 110.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.5 | 97.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 4.4 | 88.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.6 | 48.7 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 48.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 2.3 | 47.9 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 1.5 | 46.1 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 45.8 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 58.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.6 | 50.4 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 1.7 | 43.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 1.4 | 38.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 1.1 | 38.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 1.5 | 29.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.4 | 23.6 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.9 | 20.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.5 | 20.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.3 | 20.2 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 124.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.6 | 87.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 62.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 50.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.5 | 42.5 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.9 | 42.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 41.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.5 | 39.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.5 | 36.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.7 | 36.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |