ISMARA results: Fli1

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Fli1

Z-value: 1.86

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Transcription factors associated with Fli1

Gene Symbol	Gene ID	Gene Info
Fli1 Ensembl NCBI MGI UniProt	ENSMUSG00000016087.14	Fli1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Fli1	mm39_v1_chr9_-_32452885_32452898	-0.20	8.6e-02	Click!

Activity profile of Fli1 motif

Sorted Z-values of Fli1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Fli1

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Promoter	Score	Transcript	Gene	Gene Info
chr19_-_40175709 Show fit	81.19	ENSMUST00000051846.13	Cyp2c70 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily c, polypeptide 70
chr5_-_89583469 Show fit	52.96	ENSMUST00000200534.2	Gc Ensembl NCBI MGI UniProt Show fit	vitamin D binding protein
chr9_-_57590926 Show fit	38.84	ENSMUST00000034860.5	Cyp1a2 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 1, subfamily a, polypeptide 2
chr7_-_26638802 Show fit	36.16	ENSMUST00000170227.3	Cyp2a22 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily a, polypeptide 22
chr15_-_96918203 Show fit	32.59	ENSMUST00000166223.2	Slc38a4 Ensembl NCBI MGI UniProt Show fit	solute carrier family 38, member 4
chr15_-_96917804 Show fit	30.86	ENSMUST00000231039.2	Slc38a4 Ensembl NCBI MGI UniProt Show fit	solute carrier family 38, member 4
chr8_-_25066313 Show fit	24.39	ENSMUST00000121992.2	Ido2 Ensembl NCBI MGI UniProt Show fit	indoleamine 2,3-dioxygenase 2
chr17_-_32643131 Show fit	23.97	ENSMUST00000236386.2	Pglyrp2 Ensembl NCBI MGI UniProt Show fit	peptidoglycan recognition protein 2
chr17_-_32643067 Show fit	22.40	ENSMUST00000237130.2	Pglyrp2 Ensembl NCBI MGI UniProt Show fit	peptidoglycan recognition protein 2
chr14_-_55204023 Show fit	15.59	ENSMUST00000124930.8	Myh6 Ensembl NCBI MGI UniProt Show fit	myosin, heavy polypeptide 6, cardiac muscle, alpha

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	117.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
1.1	61.2	GO:0003333	amino acid transmembrane transport(GO:0003333)
2.5	53.0	GO:0042359	vitamin D metabolic process(GO:0042359)
7.7	46.4	GO:0032827	negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
9.7	38.8	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
7.8	31.3	GO:0007522	visceral muscle development(GO:0007522)
0.0	24.6	GO:0007608	sensory perception of smell(GO:0007608)
2.2	24.4	GO:0042436	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
2.6	23.0	GO:0006572	tyrosine catabolic process(GO:0006572)
3.6	14.2	GO:0060697	positive regulation of phospholipid catabolic process(GO:0060697)

Showing 1 to 10 of 104 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	97.6	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	61.6	GO:0070062	extracellular exosome(GO:0070062)
0.2	52.1	GO:0072562	blood microparticle(GO:0072562)
0.0	49.8	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
1.2	33.1	GO:0032982	myosin filament(GO:0032982)
1.3	14.2	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	12.5	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.6	10.9	GO:0045180	basal cortex(GO:0045180)
0.1	9.8	GO:0030018	Z disc(GO:0030018)
0.8	8.9	GO:0045098	type III intermediate filament(GO:0045098)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	117.3	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.4	61.2	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
13.2	53.0	GO:1902271	D3 vitamins binding(GO:1902271)
7.7	46.4	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
6.5	38.8	GO:0033695	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
4.5	31.3	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
8.1	24.4	GO:0033754	indoleamine 2,3-dioxygenase activity(GO:0033754)
0.7	23.0	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	14.9	GO:0004984	olfactory receptor activity(GO:0004984)
2.4	14.2	GO:0060230	lipoprotein lipase activator activity(GO:0060230)

Showing 1 to 10 of 68 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.0	PID E2F PATHWAY	E2F transcription factor network
0.2	13.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	12.2	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	8.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	6.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	5.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	4.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	3.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	2.7	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	2.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	61.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.3	53.0	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
12.9	38.8	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.1	33.8	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.5	31.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.7	24.4	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.4	20.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.7	14.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
1.0	14.0	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.3	10.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 10 of 29 entries

Results for Fli1

Z-value: 1.86

Motif logo

Transcription factors associated with Fli1

Activity-expression correlation:

Activity profile of Fli1 motif

Sorted Z-values of Fli1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Fli1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: