ISMARA results: Foxa2

Project

PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

Navigation

Downloads

Results for Foxa2_Foxa1

Z-value: 2.74

Motif logo

Transcription factors associated with Foxa2_Foxa1

Gene Symbol	Gene ID	Gene Info
Foxa2 Ensembl NCBI MGI UniProt	ENSMUSG00000037025.12	Foxa2
Foxa1 Ensembl NCBI MGI UniProt	ENSMUSG00000035451.8	Foxa1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxa2	mm39_v1_chr2_-_147888816_147888912	0.84	1.8e-20	Click!
Foxa1	mm39_v1_chr12_-_57592907_57592926	0.73	2.2e-13	Click!

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr4_+_104623505 Show fit	52.90	ENSMUST00000031663.10 ENSMUST00000065072.7	C8b Ensembl NCBI MGI UniProt Show fit	complement component 8, beta polypeptide
chr5_-_87054796 Show fit	43.62	ENSMUST00000031181.16 ENSMUST00000113333.2	Ugt2b34 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 2 family, polypeptide B34
chr12_+_8027640 Show fit	38.12	ENSMUST00000171271.8 ENSMUST00000037811.13	Apob Ensembl NCBI MGI UniProt Show fit	apolipoprotein B
chr12_+_8027767 Show fit	37.46	ENSMUST00000037520.14	Apob Ensembl NCBI MGI UniProt Show fit	apolipoprotein B
chr16_+_22710785 Show fit	33.61	ENSMUST00000023583.7 ENSMUST00000232098.2	Ahsg Ensembl NCBI MGI UniProt Show fit	alpha-2-HS-glycoprotein
chr15_+_54274151 Show fit	32.31	ENSMUST00000036737.4	Colec10 Ensembl NCBI MGI UniProt Show fit	collectin sub-family member 10
chr4_-_57916283 Show fit	31.61	ENSMUST00000063816.6	D630039A03Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA D630039A03 gene
chr8_-_45747883 Show fit	31.36	ENSMUST00000026907.6	Klkb1 Ensembl NCBI MGI UniProt Show fit	kallikrein B, plasma 1
chr15_-_96929086 Show fit	31.05	ENSMUST00000230086.2	Slc38a4 Ensembl NCBI MGI UniProt Show fit	solute carrier family 38, member 4
chrX_+_100419965 Show fit	30.71	ENSMUST00000119080.8	Gjb1 Ensembl NCBI MGI UniProt Show fit	gap junction protein, beta 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
5.6	78.0	GO:0006642	triglyceride mobilization(GO:0006642)
15.5	77.5	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
2.3	72.7	GO:0015721	bile acid and bile salt transport(GO:0015721)
1.2	67.6	GO:0003333	amino acid transmembrane transport(GO:0003333)
8.3	57.9	GO:2001205	negative regulation of osteoclast development(GO:2001205)
3.5	52.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
11.5	45.9	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.3	44.9	GO:0006958	complement activation, classical pathway(GO:0006958)
1.2	36.3	GO:0008211	glucocorticoid metabolic process(GO:0008211)
0.1	35.1	GO:0010466	negative regulation of peptidase activity(GO:0010466)

Showing 1 to 10 of 189 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	244.2	GO:0005615	extracellular space(GO:0005615)
0.5	123.2	GO:0072562	blood microparticle(GO:0072562)
25.2	75.6	GO:0034359	mature chylomicron(GO:0034359)
8.3	74.6	GO:0005579	membrane attack complex(GO:0005579)
0.2	65.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.5	59.2	GO:0005581	collagen trimer(GO:0005581)
0.2	43.5	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2	40.3	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
1.3	36.3	GO:0005922	connexon complex(GO:0005922)
3.1	31.2	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)

Showing 1 to 10 of 64 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	129.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
8.1	105.8	GO:0035473	lipase binding(GO:0035473)
0.5	69.1	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
1.5	59.3	GO:0042056	chemoattractant activity(GO:0042056)
0.6	50.0	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.1	48.9	GO:0005198	structural molecule activity(GO:0005198)
1.1	45.1	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.3	43.3	GO:0005178	integrin binding(GO:0005178)
4.9	39.4	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	36.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Showing 1 to 10 of 125 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	130.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.5	110.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	80.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.0	55.2	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5	36.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	30.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.5	28.8	PID BMP PATHWAY	BMP receptor signaling
0.3	21.7	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.2	21.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	20.8	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	121.5	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.4	91.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
2.5	77.2	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.5	62.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
2.2	50.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
2.3	47.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	43.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
3.6	39.4	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
1.6	36.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.6	29.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 67 entries

Results for Foxa2_Foxa1

Z-value: 2.74

Motif logo

Transcription factors associated with Foxa2_Foxa1

Activity-expression correlation:

Activity profile of Foxa2_Foxa1 motif

Sorted Z-values of Foxa2_Foxa1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa2_Foxa1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: