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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Foxl1

Z-value: 0.53

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Transcription factors associated with Foxl1

Gene Symbol Gene ID Gene Info
Foxl1
ENSMUSG00000097084.2 Foxl1
Foxl1
ENSMUSG00000097084.2 Foxl1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxl1mm39_v1_chr8_+_121854566_121854679-0.161.8e-01Click!

Activity profile of Foxl1 motif

Sorted Z-values of Foxl1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxl1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_15107646 4.03 ENSMUST00000033842.4
Myom2
myomesin 2
chr3_-_122828592 3.08 ENSMUST00000029761.14
Myoz2
myozenin 2
chr7_-_119078472 2.91 ENSMUST00000209095.2
ENSMUST00000033263.6
ENSMUST00000207261.2
Umod
uromodulin
chr15_-_11905697 2.48 ENSMUST00000066529.5
ENSMUST00000228603.2
Npr3
natriuretic peptide receptor 3
chr5_-_83502966 2.29 ENSMUST00000053543.11
Tecrl
trans-2,3-enoyl-CoA reductase-like
chr9_+_71123061 2.28 ENSMUST00000034723.6
Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr7_-_119078330 2.24 ENSMUST00000207460.2
Umod
uromodulin
chr18_-_15284476 2.21 ENSMUST00000025992.7
Kctd1
potassium channel tetramerisation domain containing 1
chr9_+_121606750 2.07 ENSMUST00000098272.4
Klhl40
kelch-like 40
chr10_+_56253418 1.79 ENSMUST00000068581.9
ENSMUST00000217789.2
Gja1
gap junction protein, alpha 1
chr6_-_101176147 1.77 ENSMUST00000239140.2
Pdzrn3
PDZ domain containing RING finger 3
chr1_+_66426127 1.58 ENSMUST00000145419.8
Map2
microtubule-associated protein 2
chr6_-_144978557 1.57 ENSMUST00000136819.3
Bcat1
branched chain aminotransferase 1, cytosolic
chr18_+_37637317 1.56 ENSMUST00000052179.8
Pcdhb20
protocadherin beta 20
chr18_+_37864045 1.53 ENSMUST00000192535.2
Pcdhgb5
protocadherin gamma subfamily B, 5
chr5_+_102629240 1.52 ENSMUST00000073302.12
ENSMUST00000094559.9
Arhgap24
Rho GTPase activating protein 24
chr9_-_101076198 1.50 ENSMUST00000066773.9
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr15_-_98705791 1.37 ENSMUST00000075444.8
Ddn
dendrin
chr5_+_102629365 1.33 ENSMUST00000112854.8
Arhgap24
Rho GTPase activating protein 24
chr18_-_31580436 1.28 ENSMUST00000025110.5
Syt4
synaptotagmin IV
chr5_-_83502793 1.27 ENSMUST00000146669.2
Tecrl
trans-2,3-enoyl-CoA reductase-like
chr1_-_169938060 1.24 ENSMUST00000027985.8
ENSMUST00000194690.6
Ddr2
discoidin domain receptor family, member 2
chr16_-_22258469 1.04 ENSMUST00000079601.13
Etv5
ets variant 5
chr6_-_14755249 1.01 ENSMUST00000045096.6
Ppp1r3a
protein phosphatase 1, regulatory subunit 3A
chr1_-_169938298 0.99 ENSMUST00000192312.6
Ddr2
discoidin domain receptor family, member 2
chr13_-_23806530 0.80 ENSMUST00000062045.4
H1f4
H1.4 linker histone, cluster member
chr9_+_43980718 0.79 ENSMUST00000114830.9
Usp2
ubiquitin specific peptidase 2
chr3_-_146475974 0.73 ENSMUST00000106137.8
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr18_-_25886750 0.70 ENSMUST00000224553.2
ENSMUST00000025117.14
Celf4
CUGBP, Elav-like family member 4
chr18_+_36431732 0.68 ENSMUST00000210490.3
Igip
IgA inducing protein
chr16_-_22258320 0.67 ENSMUST00000170393.2
Etv5
ets variant 5
chr6_+_42263609 0.63 ENSMUST00000238845.2
ENSMUST00000031894.13
Clcn1
chloride channel, voltage-sensitive 1
chrX_+_132751729 0.56 ENSMUST00000033602.9
Tnmd
tenomodulin
chr8_+_93553901 0.51 ENSMUST00000034187.9
Mmp2
matrix metallopeptidase 2
chr7_+_90739904 0.49 ENSMUST00000107196.10
ENSMUST00000074273.10
Dlg2
discs large MAGUK scaffold protein 2
chr1_+_179788037 0.49 ENSMUST00000097453.9
ENSMUST00000111117.8
Cdc42bpa
CDC42 binding protein kinase alpha
chr17_-_91400142 0.41 ENSMUST00000160800.9
Nrxn1
neurexin I
chr2_+_91086489 0.40 ENSMUST00000154959.8
ENSMUST00000059566.11
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr6_-_102441628 0.35 ENSMUST00000032159.7
Cntn3
contactin 3
chr6_-_57877975 0.30 ENSMUST00000228322.2
Vmn1r22
vomeronasal 1 receptor 22
chr2_+_119156265 0.29 ENSMUST00000102517.4
Dll4
delta like canonical Notch ligand 4
chr6_-_147165623 0.24 ENSMUST00000052296.9
ENSMUST00000204197.2
Pthlh
parathyroid hormone-like peptide
chr10_-_102326286 0.02 ENSMUST00000020040.5
Nts
neurotensin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0072023 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
0.6 1.8 GO:0060156 vascular transport(GO:0010232) milk ejection(GO:0060156)
0.3 2.3 GO:0035799 ureter maturation(GO:0035799)
0.3 2.8 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 2.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.2 4.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 2.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.2 1.5 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.2 1.6 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 1.7 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 3.6 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 1.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 2.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.3 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.2 GO:0060618 nipple development(GO:0060618)
0.1 0.4 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.7 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.8 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 3.1 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 1.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.5 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 4.0 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.8 GO:0005916 fascia adherens(GO:0005916)
0.1 1.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.1 GO:0031672 A band(GO:0031672)
0.0 5.2 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.1 GO:0030018 Z disc(GO:0030018)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0051373 FATZ binding(GO:0051373)
0.4 5.2 GO:0019864 IgG binding(GO:0019864)
0.4 1.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.4 2.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.3 2.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 1.8 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.2 2.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 1.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 4.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.2 1.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 3.6 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.8 GO:0030332 cyclin binding(GO:0030332)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 1.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 2.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases